Exposure to elemental composition of outdoor PM2.5 at birth and cognitive and psychomotor function in childhood in four European birth cohorts (Publications)
composition. We aimed to investigate associations between exposure to elemental composition of outdoor PM2.5 at birth and cognitive and psychomotor functions in childhood. METHODS: We analyzed data from 4 European [...] Netherlands, Germany, Italy and Spain, with recruitment in 2000-2006. Elemental composition of PM2.5 measurements were performed in each region in 2008-2011 and land use regression models were used to
Global, regional, and national under-5 mortality, adult mortality, age-specific mortality, and life expectancy, 1970-2016: a systematic analysis for... (Publications)
deaths in children younger than 5 years decreased from 1970 to 2016, and slower decreases occurred at ages 5-24 years. By contrast, numbers of adult deaths increased in each 5-year age bracket above the age [...] For other locations, we took advantage of different data sources available to measure under-5 mortality rates (U5MR) using complete birth histories, summary birth histories, and incomplete VR with adjustments; [...] distribution methods for adults and from consideration of survey and...
Antileukemic ancistrobenomine B and related 5,1′-coupled naphthylisoquinoline alkaloids from the Chinese liana <em>Ancistrocladus tectorius</em> (Publications)
predominance of 5,1'-coupled naphthylisoquinoline alkaloids. About 20 alkaloids of this coupling type have so far been discovered in this plant species. Here, we report on the isolation of four new 5,1'-linked [...] naphthylisoquinolines from the twigs and stems of A. tectorius. Two of them, the ancistrobenomines B (5) and C (6), belong to the very rare group of alkaloids with a fully dehydrogenated isoquinoline portion [...] from one single naphthalene-devoid 3-hydroxymethyleneisoquinoline from...
Acceptability of pre-referral rectal artesunate for severe malaria in children under 5 years by health workers and caregivers in the Democratic... (Publications)
facility workers), with caregivers of children < 5 years of age during three household surveys (N = 9332 caregivers), and with caregivers of children < 5 years of age who were treated with RAS and enrolled
Genome-wide analyses identify <em>SCN5A</em> as a susceptibility locus for premature atrial contraction frequency (Publications)
European ancestry. We identified a genome-wide significant locus at the SCN5A gene. The lead variant, rs7373862, located in an intron of SCN5A, was associated with an increase of 0.12 [95% CI 0.08-0.16] standard [...] there was a significant enrichment in concordance of effect for PAC frequency (n = 73/106, p = 5.1 x 10(-5)). However, several AF risk loci, including PITX2, were not associated with PAC frequency. These
The air and viruses we breathe: assessing the effect the PM2.5 air pollutant has on the burden of COVID-19 (Publications)
burden of respiratory viral diseases. We assessed the effect of increasing exposure to PM2.5 (particulate matter ≤ 2.5 microns in diameter) on SARS-CoV-2 susceptibility or COVID-19 severity and projected the [...] population show that if exposure affects severity, then hospital admissions are projected to increase by 5–10% for a one-unit exposure increase. However, if exposure affects susceptibility, then infections would [...] respond to changing air pollution levels. It is also important to...