Macyranones: structure, biosynthesis, and binding mode of an unprecedented epoxyketone that targets the 20S proteasome (Publications)
the yeast 20S proteasome with an IC50 of 5.9 nM and the human constitutive proteasome and immunoproteasome with IC50 values of 21 and 15 nM, respectively. The beta5 subunit of the 20S proteasome was characterized [...] presence of the methylmalonamide residue facilitates the stabilization of macyranone A with the active beta5 subunit of the proteasome. Macyranone A exhibits a potent inhibitory effect against the parasites T
Low prevalence of bovine tuberculosis in Somali pastoral livestock, southeast Ethiopia (Publications)
7.0-14.0%), and 1.9 (95% CI, 0.9-4.0%), respectively, whereby camels had an odds ratio of 16.5 (95% CI, 5.0-55.0) when compared to cattle. There was no significant difference between livestock species [...] model for each species. The individual animal prevalence was 2.0% [95% confidence interval (CI), 0.5-8.4], 0.4% (95% CI, 0.1-3%), and 0.2% (95% CI, 0.03-1.3) in cattle, camels, and goats, respectively
New loci associated with kidney function and chronic kidney disease (Publications)
(eGFRcys) and CKD (eGFRcrea < 60 ml/min/1.73 m(2); n = 5,807 individuals with CKD (cases)). Follow-up of the 23 new genome-wide-significant loci (P < 5 x 10(-8)) in 22,982 replication samples identified 13 [...] affecting renal function and CKD (in or near LASS2, GCKR, ALMS1, TFDP2, DAB2, SLC34A1, VEGFA, PRKAG2, PIP5K1B, ATXN2, DACH1, UBE2Q2 and SLC7A9) and 7 loci suspected to affect creatinine production and secretion
Limited value of whole blood Xpert® MTB/RIF for diagnosing tuberculosis in children (Publications)
14 (6.0%) had culture-confirmed tuberculosis. The Xpert(R) MTB/RIF assay detected M. tuberculosis in 5/232 (2.2%) blood samples with 1 (0.4%) error reading and presumably 1 (0.4%) false-positive result. [...] assay in children with culture-confirmed (1/14) versus no tuberculosis (1/117) was 7.1% (95% CI, 1.3-31.5). Three of the five Xpert(R) MTB/RIF positive patients had negative cultures, but were classified as [...] against a composite reference standard (culture-confirmed, highly probable or...
Macyranones: structure, biosynthesis, and binding mode of an unprecedented epoxyketone that targets the 20S proteasome (Publications)
the yeast 20S proteasome with an IC50 of 5.9 nM and the human constitutive proteasome and immunoproteasome with IC50 values of 21 and 15 nM, respectively. The beta5 subunit of the 20S proteasome was characterized [...] presence of the methylmalonamide residue facilitates the stabilization of macyranone A with the active beta5 subunit of the proteasome. Macyranone A exhibits a potent inhibitory effect against the parasites T
One-hour rule-in and rule-out of acute myocardial infarction using high-sensitivity cardiac troponin I (Publications)
developed in the derivation cohort to the validation cohort, 50.5% of patients could be classified as "rule-out", 19% as "rule-in", 30.5% as "observe ". In the validation cohort the negative predictive [...] positive predictive value (PPV) for acute myocardial infarction in the "rule-in" zone was 75.6% (95%CI, 68.5-81.8%), respectively. NPV of the 1h-algorithm was higher compared to the classical dichotomous inte
Low prevalence of bovine tuberculosis in Somali pastoral livestock, southeast Ethiopia (Publications)
7.0-14.0%), and 1.9 (95% CI, 0.9-4.0%), respectively, whereby camels had an odds ratio of 16.5 (95% CI, 5.0-55.0) when compared to cattle. There was no significant difference between livestock species [...] model for each species. The individual animal prevalence was 2.0% [95% confidence interval (CI), 0.5-8.4], 0.4% (95% CI, 0.1-3%), and 0.2% (95% CI, 0.03-1.3) in cattle, camels, and goats, respectively
Field issues related to effectiveness of insecticide-treated nets in Tanzania (Publications)
environment. Finally, bioassays were carried out with Anopheles gambiae on polyester netting with 0.5, 2, 5, 10 and 30 mg/m(2) of deltamethrin, alphacypermethrin and lambdacyhalothrin to assess the effectiveness [...] the 20% of nets that were reported as having been re-treated within the last 12 months had less than 5 mg/m(2) of insecticide. According to the World Health Organization this is insufficient to be effective
The epidemiology of multiple <em>Plasmodium falciparum</em> infections. 10. Effect of insecticide-treated bed nets on the dynamics of multiple... (Publications)
Plasmodium falciparum merozoite surface protein 2 (msp2) gene were studied in 120 children aged 5 months to 2.5 years, in a randomized controlled trial of insecticide-treated bed nets (ITNs) in Kiberege village [...] polymerase chain reaction-restriction fragment length polymorphism analysis in any one sample of 0.5 microL of packed peripheral blood cells. In children less than 18 months old this sensitivity was 61%
Estimating population and livestock density of mobile pastoralists and sedentary settlements in the south-eastern Lake Chad area (Publications)
were estimated to live in sedentary villages. In the mobile communities, we found 5.9 people per km2 at the beginning and 17.5 people per km2 at the end of the dry season. We recorded per km2 on average 21 [...] 21.0 cattle and 31.6 small ruminants in the sedentary villages and 66.1 cattle and 102.5 small ruminants in the mobile communities, which amounts to a mean of 86.6 tropical livestock units during the dry
