Comparison of traditional cox regression and causal modeling to investigate the association between long-term air pollution exposure and natural-cause... (Publications)
European countries. Annual mean PM(2.5) and NO(2) from Europe-wide models were assigned to baseline residential addresses and dichotomized at selected cut-off values (PM(2.5): 10, 12, 15 mug/m(3); NO(2): 20 [...] compared the associations between natural-cause mortality and exposure to fine particulate matter (PM(2.5)) and nitrogen dioxide (NO(2)) using traditional Cox and causal models in a large multicenter cohort [...] pooled and administrative cohorts, 47,131 and 3,580,264 died from natural...
Performance of antigen detection for HRP2-based malaria rapid diagnostic tests in community surveys: Tanzania, July-November 2017 (Publications)
lower LOD at the 95% probability of positive RDT (4.3 ng/mL; 95% CI 3.4-5.4) when compared to pLDH/HRP2 dual target tests (5.4 ng/mL; 4.5-6.3), though this difference was not significant. With the exception [...] all other 14 villages (93.3%) showed RDT LOD estimates at 90% probability of positive RDT between 0.5 and 12.0 ng/mL. CONCLUSIONS: Both HRP2-only and pLDH/HRP2 combo RDTs utilized in a 2017 Tanzania cr
Prevalence and risk factors of schistosomiasis and hookworm infection in seasonal transmission settings in northern Côte d'Ivoire: a cross-sectional... (Publications)
two departments; Ferkessédougou (5.4%, 95% CI: 2.5-9.9%) and Ouangolodougou (2.7%, 95% CI: 0.9-6.3%). Hookworm was the only STH species observed with a prevalence of 1.5% (95% CI: 0.8-2.8%). A higher risk [...] females, but the difference was not statistically significant (2.3% versus 1.3%, odds ratio [OR]: 1.5, 95% CI: 0.8-2.7). Participants aged 16-20 years showed the highest prevalence of S. haematobium. A
Prevalence and associated risk factors of intestinal parasitic infections among children in pastoralist and agro-pastoralist communities in the Adadle... (Publications)
and from collected rainwater (aOR 9.48, 95%CI 3.39, 26.5), with toilet sharing (aOR 2.93, 95%CI 1.36, 6.31) and with household ownership of cattle (1-5 cattle: aOR 1.65, 95%CI 1.13, 2.41; 6+ cattle: aOR 2 [...] IPIs and associated risk factors during the wet season from May-June 2021 in 366 children aged 2 to 5 years in four agro-pastoralist and four pastoralist kebeles (wards) in Adadle woreda (district) of the [...] was 24.9%: 21.9% Giardia intestinalis, and 3.0% Entamoeba spp.. Intestinal...
Farmers' valuation and willingness to pay for vaccines to protect livestock resources against priority infectious diseases in Ghana (Publications)
Mean WTP for PPR vaccination was USD 1.17 or GHC 7.02 (95% CI: GHC 5.99-GHC 8.05) per sheep, and USD 1.1 or GHC 6.66 (95% CI: GHC 5.89-GHC 7.44) per goat. WTP was positively associated with resilience [...] covariates. To attain 70% vaccination coverage in Ghana, vaccination costs should be no larger than GHC 5.30 (USD 0.88) for CBPP per cattle and GHC 3.89 (USD 0.65) and GHC 3.67 (USD 0.61), respectively, for [...] willing to pay vaccination costs that exceed the prevailing market prices (GHC...
Evaluating putative repellent 'push' and attractive 'pull' components for manipulating the odour orientation of host-seeking malaria vectors in the... (Publications)
was detectable in the air space but with a strong linear reduction in concentrations over 5 m from release. The MB5 constituent chemicals were only irregularly detected, potentially suggesting insufficient [...] positioned in house eave gaps as push components for preventing bites; (ii) understand the efficacy of MB5-baited Suna-traps in attracting vectors in the presence of a human being; (iii) assess 2-butanone as [...] was associated with low nighttime temperatures likely affecting the...
Extrapulmonary tuberculosis in HIV-infected patients in rural Tanzania: the prospective Kilombero and Ulanga antiretroviral cohort (Publications)
pulmonary Tuberculosis (PTB and EPTB were 17.9/1000person-years (py) (95% CI 14.2-22.6) and 5.8/1000 py (95% CI 4.0-8.5), respectively. The combined endpoint of death and LTFU was observed in 1058 (33.8%) patients [...] a combined endpoint of lost to follow-up (LTFU) and death. RESULTS: We included 3,129 subjects (64.5% female) with a median age of 38 years (interquartile range [IQR] 31-46) and a median CD4+ cell count [...] 1.25 years (IQR 0.46-2.85), 574 (18.4%) subjects were diagnosed with...
Chest X-ray analysis with deep learning-based software as a triage test for pulmonary tuberculosis: an individual patient data meta-analysis of... (Publications)
2% [-3.6, +6.3]; qXRv2: -13.4% [-21.5, -6.6]); between smear-negative and smear-positive tuberculosis was: CAD4TBv6, -12.3% [-19.5, -6.1]; Lunit, -17.2% [-24.6, -10.5]; qXRv2, -16.6% [-24.4, -9.9]. Accuracy [...] pooled specificities were: CAD4TBv6, 56.9% [95%CI:51.7-61.9]; Lunit, 54.1% [44.6-63.3]; qXRv2, 60.5% [51.7-68.6]). Adjusted absolute differences in pooled sensitivity between PLWH and HIV-uninfected
Data integration for the assessment of population exposure to ambient air pollution for global burden of disease assessment (Publications)
ambient PM2.5 levels exceeded the World Health Organization 10 mug/m3 (annual average) Guideline; 58% resided in areas above the 35 mug/m3 Interim Target-1. Global population-weighted PM2.5 concentrations [...] estimates. A Bayesian Hierarchical Model was developed to estimate annual average fine particle (PM2.5) concentrations at 0.1 degrees x 0.1 degrees spatial resolution globally for 2010-2016. The model i
Analysis of the physicochemical properties of anti-schistosomal compounds to identify next-generation leads (Publications)
schistosomiasis and demonstrate the importance of finding the right balance among potency (e.g., EC50 < 5 and 0.5 μM), cell permeability (e.g., Papp > 2 × 106 cm/s) and kinetic aqueous solubility (e.g., > 10 μM) [...] (PZQ), previous and currently used oral anti-schistosomal drugs, possess lower cLogD7.4 values (≤2.5). Furthermore, the lipophilicity associated with PZQ corresponds to a highly permeable and sparingly