Prospective multicentre accuracy evaluation of the FUJIFILM SILVAMP TB LAM test for the diagnosis of tuberculosis in people living with HIV... (Publications)
specificity estimates varied between sites, ranging from 26·5% (95% CI: 17·4%-38·0%) to 73·2% (60·4%-83·0%), and 75·0 (65·0%-82·9%) to 96·5 (92·1%-98·5%), respectively. Post-hoc exploratory analysis identified
The impact of acute air pollution fluctuations on bronchiectasis pulmonary exacerbation: a case-crossover analysis (Publications)
NO2, the risk of having an exacerbation that same day increased significantly by 4.5% (95%CI:0.9-8.3) and 3.2% (95%CI:0.7-5.8) respectively. The overall increase in risk of exacerbation for a 10 mug/m(3) [...] mug/m(3) increase in air pollutant concentration was 11.2% (95%CI:6.0-16.8) for PM10 and 4.7% (95%CI:0.1-9.5) for NO2 Subanalysis showed significant higher relative risks during spring (PM10 1.198, 95%CI 1.102-1
Development of prediction models to identify hotspots of schistosomiasis in endemic regions to guide mass drug administration (Publications)
challenge in eliminating schistosomiasis. Current approaches to identify hotspots require evaluation 2-5 y after a baseline survey and subsequent mass drug administration. Here, we develop statistical models [...] predicts whether Schistosoma mansoni infection prevalence will exceed the WHO threshold of 10% in year 5 ("prevalence hotspot") with 86% sensitivity, 74% specificity, and 93% negative predictive value (NPV; [...] whether S. mansoni moderate and heavy infection prevalence will exceed a...
Reproducibility of oscillometrically measured arterial stiffness indices: results of the SAPALDIA 3 cohort study (Publications)
variance was accounted for by the subject, 5.2%/8.1%/ < 0.01% by the fieldworker, 6.7%/7.8%/28.5% by variation between measurement days, and 19.4%/4%/16.5% by measurement error. Bland-Altman plots showed
Efficacy and safety of moxidectin, synriam, synriam-praziquantel <em>versus</em> praziquantel against <em>Schistosoma haematobium</em> and <em>S.... (Publications)
the other hand, Synriam plus praziquantel and praziquantel yielded CRs of 60.0% and 38.5% and ERRs of 96.0% and 93.5%, respectively. CRs observed in the treatment of S. mansoni were 13.0%, 6.7%, 27.0%, and [...] Synriam, Synriam plus praziquantel and praziquantel, respectively. ERRs ranged from 64.9% (Synriam) to 87.5% (praziquantel). CONCLUSION/SIGNIFICANCE: Synriam and moxidectin show low efficacy against S. haematobium
Short-term effects of air pollution on total and cardiovascular mortality: the confounding effect of influenza epidemics (Publications)
associated with particulates (PM10). We used 10 methods to control for epidemics (5 derived from influenza data and 5 from respiratory mortality series) and compared those results with analyses that did [...] cases (% change in the pooled regression coefficient: -1.9 to 38.9 for total mortality and 1.3 to 25.5 for cardiovascular mortality). A 10-microg/m increase in PM10 concentrations (lag 0-1) was associated
The genomes of three stocks comprising the most widely utilized live sporozoite <em>Theileria parva</em> vaccine exhibit very different degrees and... (Publications)
families. The Kiambu5 isolate is considerably more divergent, with close to 40,000 SNPs relative to Muguga, including > 8,500 non-synonymous mutations distributed among > 1,700 (42.5 %) of the predicted [...] the three component T. parva stocks within this vaccine, the Muguga Cocktail, namely Muguga, Kiambu5 and Serengeti-transformed, aiming to identify genomic features that contribute to vaccine efficacy.
Association between short term exposure to fine particulate matter and heart rate variability in older subjects with and without heart disease (Publications)
in 1 hour mean outdoor PM2.5 before the HRV measurement and a change in HF-HRV power in individuals with CVD (3% increase in median HF-HRV (95% CI -19 to 32)) or without CVD (5% decrease in median HF-HRV [...] (95% CI -34 to 36)). Similarly, no association was evident using 4 hour and 24 hour mean outdoor PM2.5 exposures before the HRV measurement. CONCLUSION: No association was found between increased residence
Cholesterol screening in childhood: results of a 9-year follow-up study in Swiss and Italian children in Switzerland (Publications)
development of Swiss and immigrant schoolchildren, cardiovascular risk factors were assessed at the ages of 5, 10 and 14 years. The age-specific levels of total and LDL-cholesterol found in our study were slightly [...] found in the Bogalusa Heart Study. For total cholesterol no significant tracking correlations over the 5 and 9 year periods were found. Tracking of LDL- and HDL-cholesterol differed between nationalities and [...] different sampling and laboratory methods. Individual changes in...
High temperature and hospitalizations for cardiovascular and respiratory causes in 12 European cities (Publications)
above a threshold, respiratory admissions increased by +4.5% (95% confidence interval, 1.9-7.3) and +3.1% (95% confidence interval, 0.8-5.5) in the 75+ age group in Mediterranean and North-Continental