Strengthening HIV therapy and care in rural Tanzania affects rates of viral suppression (Publications)
logistic regression. Results: This study included 304 participants with a median time on ART of 3.5 years (IQR = 1.7-5.3 years); 91% were on an NNRTI-based regimen and 9% were on a boosted PI-based regimen. Viral [...] successfully genotyped and 17/21 (81%) harboured > /=1 clinically relevant HIV-DRM. Of these, 13/17 (76.5%) had HIV-1 plasma viral loads of > 1000 copies/mL. CD4 cell count 8-fold increased odds of developing
Spatial variability of nitrogen dioxide and formaldehydeand residential exposure of children in the industrial area of Viadana, Northern Italy (Publications)
with hot-spots in proximity to theindustry. PM10and PM2.5exposures were higher for children at < 1 km compared to the children living at > 3.5 km to theindustry, whereas NO2exposure was higher at 1–1 [...] as well as other available countrywide/continental models basedon routine data on NO2, PM10, andPM2.5. The correlation between NO2concentrations from continuous and passive samplingwas high (Pearson’sr=
Clinical diversity and treatment results in tegumentary leishmaniasis: a European clinical report in 459 patients (Publications)
associated with mucosal involvement (2.7% vs 5.3%). Patients with mucosal lesions were older (58 vs 30 years) and more frequently immunocompromised (37% vs 3.5%) compared to patients with only skin lesions [...] braziliensis or L. guyanensis complex typically had an ulcer of the lower limbs with mucosal involvement in 5.8% of cases. Typically, infections with L. major and L. tropica acquired in Africa or the Middle East
Population pharmacokinetics of antimalarial naphthoquine in combination with artemisinin in Tanzanian children and adults: dose optimization (Publications)
adults and children over 5 years of age (6 to 10, 11 to 17, and > /=18 years of age) with uncomplicated malaria in Tanzania. The median weights for the three age groups were 20, 37.5, and 55 kg, respectively [...] weight and 44.3-kg fat-free mass) were estimated as 66.7 L/h (95% confidence interval [CI], 57.3 to 78.5 L/h) for artemisinin and 44.2 L/h (95% CI, 37.9 to 50.6 L/h) for naphthoquine. Nevertheless, we show
Indoors man-biting mosquitoes and their implication on malaria transmission in Mpwapwa and Iringa Districts, Tanzania (Publications)
Culex quinquefasciatus. Other species including Cx cinereus, An. coustani and Aedes spp accounted for 0.5% of the mosquito population. In Iringa, more mosquitoes were collected by pyrethrum spray catch than [...] trapping technique. The light trap catch: spray catch ratio in Iringa and Mpwapwa was 1:1.15 and 2.5:1, respectively. Indoor pyrethrum spray catch gave an overall estimate of An. gambiae density of 8 and [...] densities of house entering mosquitoes were found to range from 0 to 135 in...
Sex-specific effect of body weight gain on systemic inflammation in subjects with COPD: results from the SAPALDIA cohort study 2 (Publications)
examined the association of hs-CRP and categories of body weight change (lost weight and weight gained 0-5%, 5-9%, 9-14% and > 14%) with fast FEV(1) decline. hs-CRP was elevated both in association with fast FEV(1) [...] and sex. Using data from the Swiss study on Air Pollution and Lung Diseases in Adults (SAPALDIA; n = 5,479) with measurements of forced expiratory volume in 1 s (FEV(1)), body weight and hs-CRP, we examined
Indoors man-biting mosquitoes and their implication on malaria transmission in Mpwapwa and Iringa Districts, Tanzania (Publications)
Culex quinquefasciatus. Other species including Cx cinereus, An. coustani and Aedes spp accounted for 0.5% of the mosquito population. In Iringa, more mosquitoes were collected by pyrethrum spray catch than [...] trapping technique. The light trap catch: spray catch ratio in Iringa and Mpwapwa was 1:1.15 and 2.5:1, respectively. Indoor pyrethrum spray catch gave an overall estimate of An. gambiae density of 8 and [...] densities of house entering mosquitoes were found to range from 0 to 135 in...
Sex-specific effect of body weight gain on systemic inflammation in subjects with COPD: results from the SAPALDIA cohort study 2 (Publications)
examined the association of hs-CRP and categories of body weight change (lost weight and weight gained 0-5%, 5-9%, 9-14% and > 14%) with fast FEV(1) decline. hs-CRP was elevated both in association with fast FEV(1) [...] and sex. Using data from the Swiss study on Air Pollution and Lung Diseases in Adults (SAPALDIA; n = 5,479) with measurements of forced expiratory volume in 1 s (FEV(1)), body weight and hs-CRP, we examined
Short-term effects of air pollution on total and cardiovascular mortality: the confounding effect of influenza epidemics (Publications)
associated with particulates (PM10). We used 10 methods to control for epidemics (5 derived from influenza data and 5 from respiratory mortality series) and compared those results with analyses that did [...] cases (% change in the pooled regression coefficient: -1.9 to 38.9 for total mortality and 1.3 to 25.5 for cardiovascular mortality). A 10-microg/m increase in PM10 concentrations (lag 0-1) was associated
Association between short term exposure to fine particulate matter and heart rate variability in older subjects with and without heart disease (Publications)
in 1 hour mean outdoor PM2.5 before the HRV measurement and a change in HF-HRV power in individuals with CVD (3% increase in median HF-HRV (95% CI -19 to 32)) or without CVD (5% decrease in median HF-HRV [...] (95% CI -34 to 36)). Similarly, no association was evident using 4 hour and 24 hour mean outdoor PM2.5 exposures before the HRV measurement. CONCLUSION: No association was found between increased residence