Short-term effects of air pollution on total and cardiovascular mortality: the confounding effect of influenza epidemics (Publications)
associated with particulates (PM10). We used 10 methods to control for epidemics (5 derived from influenza data and 5 from respiratory mortality series) and compared those results with analyses that did [...] cases (% change in the pooled regression coefficient: -1.9 to 38.9 for total mortality and 1.3 to 25.5 for cardiovascular mortality). A 10-microg/m increase in PM10 concentrations (lag 0-1) was associated
The genomes of three stocks comprising the most widely utilized live sporozoite <em>Theileria parva</em> vaccine exhibit very different degrees and... (Publications)
families. The Kiambu5 isolate is considerably more divergent, with close to 40,000 SNPs relative to Muguga, including > 8,500 non-synonymous mutations distributed among > 1,700 (42.5 %) of the predicted [...] the three component T. parva stocks within this vaccine, the Muguga Cocktail, namely Muguga, Kiambu5 and Serengeti-transformed, aiming to identify genomic features that contribute to vaccine efficacy.
Association between short term exposure to fine particulate matter and heart rate variability in older subjects with and without heart disease (Publications)
in 1 hour mean outdoor PM2.5 before the HRV measurement and a change in HF-HRV power in individuals with CVD (3% increase in median HF-HRV (95% CI -19 to 32)) or without CVD (5% decrease in median HF-HRV [...] (95% CI -34 to 36)). Similarly, no association was evident using 4 hour and 24 hour mean outdoor PM2.5 exposures before the HRV measurement. CONCLUSION: No association was found between increased residence
Cholesterol screening in childhood: results of a 9-year follow-up study in Swiss and Italian children in Switzerland (Publications)
development of Swiss and immigrant schoolchildren, cardiovascular risk factors were assessed at the ages of 5, 10 and 14 years. The age-specific levels of total and LDL-cholesterol found in our study were slightly [...] found in the Bogalusa Heart Study. For total cholesterol no significant tracking correlations over the 5 and 9 year periods were found. Tracking of LDL- and HDL-cholesterol differed between nationalities and [...] different sampling and laboratory methods. Individual changes in...
High temperature and hospitalizations for cardiovascular and respiratory causes in 12 European cities (Publications)
above a threshold, respiratory admissions increased by +4.5% (95% confidence interval, 1.9-7.3) and +3.1% (95% confidence interval, 0.8-5.5) in the 75+ age group in Mediterranean and North-Continental
Strengthening HIV therapy and care in rural Tanzania affects rates of viral suppression (Publications)
logistic regression. Results: This study included 304 participants with a median time on ART of 3.5 years (IQR = 1.7-5.3 years); 91% were on an NNRTI-based regimen and 9% were on a boosted PI-based regimen. Viral [...] successfully genotyped and 17/21 (81%) harboured > /=1 clinically relevant HIV-DRM. Of these, 13/17 (76.5%) had HIV-1 plasma viral loads of > 1000 copies/mL. CD4 cell count 8-fold increased odds of developing
Spatial variability of nitrogen dioxide and formaldehydeand residential exposure of children in the industrial area of Viadana, Northern Italy (Publications)
with hot-spots in proximity to theindustry. PM10and PM2.5exposures were higher for children at < 1 km compared to the children living at > 3.5 km to theindustry, whereas NO2exposure was higher at 1–1 [...] as well as other available countrywide/continental models basedon routine data on NO2, PM10, andPM2.5. The correlation between NO2concentrations from continuous and passive samplingwas high (Pearson’sr=
Clinical diversity and treatment results in tegumentary leishmaniasis: a European clinical report in 459 patients (Publications)
associated with mucosal involvement (2.7% vs 5.3%). Patients with mucosal lesions were older (58 vs 30 years) and more frequently immunocompromised (37% vs 3.5%) compared to patients with only skin lesions [...] braziliensis or L. guyanensis complex typically had an ulcer of the lower limbs with mucosal involvement in 5.8% of cases. Typically, infections with L. major and L. tropica acquired in Africa or the Middle East
Population pharmacokinetics of antimalarial naphthoquine in combination with artemisinin in Tanzanian children and adults: dose optimization (Publications)
adults and children over 5 years of age (6 to 10, 11 to 17, and > /=18 years of age) with uncomplicated malaria in Tanzania. The median weights for the three age groups were 20, 37.5, and 55 kg, respectively [...] weight and 44.3-kg fat-free mass) were estimated as 66.7 L/h (95% confidence interval [CI], 57.3 to 78.5 L/h) for artemisinin and 44.2 L/h (95% CI, 37.9 to 50.6 L/h) for naphthoquine. Nevertheless, we show
Indoors man-biting mosquitoes and their implication on malaria transmission in Mpwapwa and Iringa Districts, Tanzania (Publications)
Culex quinquefasciatus. Other species including Cx cinereus, An. coustani and Aedes spp accounted for 0.5% of the mosquito population. In Iringa, more mosquitoes were collected by pyrethrum spray catch than [...] trapping technique. The light trap catch: spray catch ratio in Iringa and Mpwapwa was 1:1.15 and 2.5:1, respectively. Indoor pyrethrum spray catch gave an overall estimate of An. gambiae density of 8 and [...] densities of house entering mosquitoes were found to range from 0 to 135 in...
