Strengthening HIV therapy and care in rural Tanzania affects rates of viral suppression (Publications)
logistic regression. Results: This study included 304 participants with a median time on ART of 3.5 years (IQR = 1.7-5.3 years); 91% were on an NNRTI-based regimen and 9% were on a boosted PI-based regimen. Viral [...] successfully genotyped and 17/21 (81%) harboured > /=1 clinically relevant HIV-DRM. Of these, 13/17 (76.5%) had HIV-1 plasma viral loads of > 1000 copies/mL. CD4 cell count 8-fold increased odds of developing
Analysis of the physicochemical properties of anti-schistosomal compounds to identify next-generation leads (Publications)
schistosomiasis and demonstrate the importance of finding the right balance among potency (e.g., EC50 < 5 and 0.5 μM), cell permeability (e.g., Papp > 2 × 106 cm/s) and kinetic aqueous solubility (e.g., > 10 μM) [...] (PZQ), previous and currently used oral anti-schistosomal drugs, possess lower cLogD7.4 values (≤2.5). Furthermore, the lipophilicity associated with PZQ corresponds to a highly permeable and sparingly
Prospective multicentre accuracy evaluation of the FUJIFILM SILVAMP TB LAM test for the diagnosis of tuberculosis in people living with HIV... (Publications)
specificity estimates varied between sites, ranging from 26·5% (95% CI: 17·4%-38·0%) to 73·2% (60·4%-83·0%), and 75·0 (65·0%-82·9%) to 96·5 (92·1%-98·5%), respectively. Post-hoc exploratory analysis identified
The impact of acute air pollution fluctuations on bronchiectasis pulmonary exacerbation: a case-crossover analysis (Publications)
NO2, the risk of having an exacerbation that same day increased significantly by 4.5% (95%CI:0.9-8.3) and 3.2% (95%CI:0.7-5.8) respectively. The overall increase in risk of exacerbation for a 10 mug/m(3) [...] mug/m(3) increase in air pollutant concentration was 11.2% (95%CI:6.0-16.8) for PM10 and 4.7% (95%CI:0.1-9.5) for NO2 Subanalysis showed significant higher relative risks during spring (PM10 1.198, 95%CI 1.102-1
Data integration for the assessment of population exposure to ambient air pollution for global burden of disease assessment (Publications)
ambient PM2.5 levels exceeded the World Health Organization 10 mug/m3 (annual average) Guideline; 58% resided in areas above the 35 mug/m3 Interim Target-1. Global population-weighted PM2.5 concentrations [...] estimates. A Bayesian Hierarchical Model was developed to estimate annual average fine particle (PM2.5) concentrations at 0.1 degrees x 0.1 degrees spatial resolution globally for 2010-2016. The model i
Development of prediction models to identify hotspots of schistosomiasis in endemic regions to guide mass drug administration (Publications)
challenge in eliminating schistosomiasis. Current approaches to identify hotspots require evaluation 2-5 y after a baseline survey and subsequent mass drug administration. Here, we develop statistical models [...] predicts whether Schistosoma mansoni infection prevalence will exceed the WHO threshold of 10% in year 5 ("prevalence hotspot") with 86% sensitivity, 74% specificity, and 93% negative predictive value (NPV; [...] whether S. mansoni moderate and heavy infection prevalence will exceed a...
<em>In vitro</em> screening of traditional South African malaria remedies against <em>Trypanosoma brucei rhodesiense</em>, <em>Trypanosoma cruzi,... (Publications)
as well as SALVIA REPENS and MAYTENUS UNDATA against LEISHMANIA DONOVANI with IC (50)s of 5.4 microg/mL and 5.6 microg/mL, respectively. This screening is the starting point for a HPLC-based activity profiling
Saharan dust, particulate matter and cause-specific mortality: a case-crossover study in Barcelona (Spain) (Publications)
during Saharan and non-Saharan days in Barcelona, Spain.METHODS: We collected daily PM(1), PM(2.5-1) and PM(10-2.5) fractions, and cause-specific mortality (cardiovascular, respiratory and cerebrovascular)
Bisabololoxide derivatives from <em>Artemisia persica</em>, and determination of their absolute configurations by ECD (Publications)
moieties of 1-5 were established on the basis of (3)J(H-H) coupling constants and NOE difference spectra. Stereochemical correlation of the two rings, and assignment of absolute configuration of 1-5 were achieved
Long-term outcome after SARS-CoV-2 infection in healthcare workers: a single centre cohort study (Publications)
infected with SARS-CoV-2. RESULTS: Persistent symptoms at 3 and 12 months were reported by 26.5% and 13.5% of participants, respectively. Most commonly reported symptoms were fatigue, impaired sense of