Immediate surgery compared with short-course neoadjuvant gemcitabine plus capecitabine, FOLFIRINOX, or chemoradiotherapy in patients with borderline... (Publications)
types of short-course neoadjuvant therapy compared with immediate surgery. METHODS: ESPAC5 (formerly known as ESPAC-5f) was a multicentre, open label, randomised controlled trial done in 16 pancreatic centres [...] cycles); or neoadjuvant capecitabine-based chemoradiation (total dose 50.4 Gy in 28 daily fractions over 5.5 weeks [1.8 Gy per fraction, Monday to Friday] with capecitabine 830 mg/m(2) twice daily [Monday to
Household-level risk factors for water contamination and antimicrobial resistance in drinking water among households with children under 5 in rural... (Publications)
presence of antibiotic resistant bacteria in drinking water among 314 households with children under 5 in Cajamarca, Peru. This study analysed data from a baseline sampling of a randomized controlled trial
Differential mortality risks associated with PM2.5 components: a multi-country, multi-city study (Publications)
BACKGROUND: The association between fine particulate matter (PM2.5) and mortality widely differs between as well as within countries. Differences in PM2.5 composition can play a role in modifying the effect estimates [...] daily total PM2.5 through time series regression analysis. We then pooled these estimates in a meta-regression model that included city-specific logratio-transformed proportions of seven PM2.5 components as [...] heterogeneity in PM2.5 risk. CONCLUSIONS: These findings...
Immunodeficiency and cancer in 3.5 million people living with Human Immunodeficiency Virus (HIV): the South African HIV cancer match study (Publications)
BACKGROUND: We analyzed associations between immunodeficiency and cancer incidence in a nationwide cohort of people living with human immunodeficiency virus (HIV; PLWH) in South Africa. METHODS: We us
Gesundheitsrisiko Mobilfunkstrahlung? Was ändert sich mit 5G? (Publications)
guideline values. With increasing mobile data usage and the associated use of higher frequencies for 5G, a densification of the mobile network is to be expected. However, this will not necessarily increase [...] the overall RF-EMF exposure of the population, as mobile phones emit less with better signal quality. 5G is a technological advancement of the previous mobile radio technology with the same biophysical properties
The Youth Attitudes about Vaccines (YAV-5) scale: adapting the parent attitudes about childhood vaccines short scale for use with youth in German,... (Publications)
YAV-14 and the YAV-5, but we only report results of the YAV-5 analysis here. We determined construct validity by logistic regression of the association between youth VH as measured by the YAV-5 and non-receipt [...] (PACV-15) for use in youth to create the version Youth Attitudes about Vaccines survey (YAV-14 and YAV-5), then translated it into three languages (German, French, and Italian). We administered the YAV-14 [...] non-immunization in the German-language sample. Our results demonstrate...
Ancistrotanzanine C and related 5,1'- and 7,3'-coupled naphthylisoquinoline alkaloids from <em>Ancistrocladus tanzaniensis</em> (Publications)
naphthylisoquinoline alkaloids, the 7,3'-coupled ancistrotanzanine C (6), the 5,1'-coupled O-methylancistrocladinine (7), and the likewise 5,1'-coupled O,N-dimethylancistrocladine (8, previously known only as a [...] two known 7,3'-coupled naphthylisoquinoline alkaloids ancistrocladidine (4) and ancistrotectorine (5). All of the compounds are S-configured at C-3 and bear an oxygen at C-6, and thus belong to the so-called
Ancistrobenomine A, the first naphthylisoquinoline oxygenated at Me-3, and related 5,1'-coupled alkaloids, from the "new" plant species... (Publications)
Three new 5,1'-coupled naphthylisoquinoline alkaloids, ancistrobenomine A (1), 6-O-demethylancistrobenomine A (2), and 5'-O-demethylancistrocline (3), have been isolated from the stem bark of a botanically
In vaccinated individuals serum bactericidal activity against B meningococci is abrogated by C5 inhibition but not by inhibition of the alternative... (Publications)
the complement components C5 and/or C3. However, complement is required for serum bactericidal activity (SBA) against encapsulated Gram-negative bacteria. Therefore, C3 and C5 inhibition increases the risk [...] against complement components other than C3 and C5 may carry a reduced risk of infection, we compared the effect of inhibitors targeting the terminal pathway (C5), the central complement component C3, the [...] H-binding protein (fHbp). SBA triggered by these cell surface...
Salidroside pretreatment alleviates PM2.5 caused lung injury via inhibition of apoptosis and pyroptosis through regulating NLRP3 inflammasome (Publications)
conditions. To uncover the possible therapy for PM(2.5) related pulmonary disease, we evaluated the protective role of Sal pre-treatment on PM(2.5) induced lung injury in mice by utilizing the survival [...] findings strongly indicated Sal as an effective precaution against PM(2.5) induced lung injury. Pre-administration of Sal before PM(2.5) treatment reduced the mortality within 120 h and alleviated inflammatory [...] PM(2.5) treatment via regulating Bax/Bcl-2/caspase-3 and...