Long-term exposure to road traffic noise, ambient air pollution, and cardiovascular risk factors in the HUNT and lifelines cohorts (Publications)
(IQR) higher day-time noise (5.1 dB(A)) was associated with 1.1% [95% confidence interval (95% CI: 0.02-2.2%)] higher hsCRP, 0.7% (95% CI: 0.3-1.1%) higher triglycerides, and 0.5% (95% CI: 0.3-0.7%) higher [...] triglycerides (1.9%, 95% CI: 1.5-2.4% and 2.2%, 95% CI: 1.6-2.7%), independent of adjustment for noise. Additionally for NO2, a significant association with hsCRP (1.9%, 95% CI: 0.5-3.3%) was seen. In Lifelines
Emodepside for<em> Trichuris trichiura </em>and hookworm infection (Publications)
CI, 6 to 35]; 5 of 30 participants). A dose-dependent relationship was shown in participants with hookworm: the observed cure rate was 32% (95% CI, 13 to 57; 6 of 19 participants) in the 5-mg emodepside [...] or hookworm eggs had been detected in stool samples to receive emodepside, at a single oral dose of 5, 10, 15, 20, 25, or 30 mg; albendazole, at a single oral dose of 400 mg; or placebo. The primary outcome [...] trichiura trial and 176 in the hookworm trial. The predicted cure rate against...
Synthesis and in vitro and in vivo evaluation of antimalarial polyamines (Publications)
2-Hydroxy and 2,5-dimethoxy analogues were typically found to exhibit the most potent activity towards the dual drug resistant strain K1 of P. falciparum with IC50's in the range of 1.3-9.5 nM, and selectivity
Efficacy of the diamidine DB75 and its prodrug DB289, against murine models of human African trypanosomiasis (Publications)
redress this situation, the recently synthesised diamidine, 2,5-bis(4-amidinophenyl)-furan (DB75, furamidine) and its methamidoxime prodrug, 2,5-bis(4-amidinophenyl)-furan-bis-O-methylamidoxime (DB289, p
Synthesis and biological evaluation of pyrazolylnaphthoquinones as new potential antiprotozoal and cytotoxic agents (Publications)
cruzi, the etiological agent of Chagas' disease. These activities were compared with those of three 5-aminoisoxazole analogues. In addition, since these compounds belong to a family of antiprotozoal and [...] trypanocidal activities against T. cruzi, with activities similar to that of benznidazole. Two of the 5-aminoisoxazole analogues also showed good activities, in one case highly selective, against the K1 and
Economic burden of underweight and overweight among adults in the Asia-Pacific region: a systematic review (Publications)
and estimate that it accounts for 1.5% to 9.9% of a country's total health care expenditure. Four articles on the economic burden of underweight estimate it at 2.5% to 3.8% of the country's total GDP.
Risk stratification for 1-year mortality in acute heart failure: classification and regression tree analysis (Publications)
patients were categorised to three risk groups: high risk group (BUN > 27.5 mg/dl and age > 86 years), intermediate risk group (BUN > 27.5 mg/dl and age
Antimalarial dibenzannulated medium-ring keto lactams (Publications)
keto lactams (11,12-dihydro-5H-dibenzo[b,g]azonine-6,13-diones) as a new antimalarial chemotype. Most of these had chromatographic LogD(7.4) values ranging from 100 μg/mL at pH 6.5). The more polar compounds
Incidence of human granulocytic anaplasmosis in returning travelers with fever (Publications)
person-week of travel. The main destination of travel was Asia, accounting for 62.5% patients with HGA. Co-infections were found in 37.5% of patients with HGA. CONCLUSIONS: Diagnosis of HGA and empirical treatment
Community transmission of SARS-CoV‑2 by surfaces: risks and risk reduction strategies (Publications)
hand-to-surface contact followed by hand-to-face contact range from 1.6×10−4 to 5.6×10−9 for modeled prevalencerates of 0.2%−5%. For observed prevalence rates (0.2%, 1%), this corresponds to a low risk of