Outcome of delivery and cause-specific mortality and severe morbidity in early infancy: a Kenyan District Hospital birth cohort (Publications)
were delivered. Of these, 136 (6%) were stillborn and 77 (3.5%) subsequently died. Prematurity (34%), birth asphyxia (27%), and infection (18.5%) were the predominant causes of death in the first 98 days
Optimization of potent inhibitors of <em>P. falciparum</em> dihydroorotate dehydrogenase for the treatment of malaria (Publications)
is for survival. We report herein the synthesis and structure-activity relationship of a series of 5-(2-methylbenzimidazol-1-yl)-N-alkylthiophene-2-carboxamides that are potent inhibitors against PfDHODH [...] potential drug-drug interactions, acceptable ADME/pharmacokinetic profile, and projected human dose, 5-(4-cyano-2-methyl-1H-benzo[d]imidazol-1-yl)-N-cyclopropylthiophene-2-carboxamide 2q was identified as
A randomised, controlled trial of once daily and multi-dose daily gentamicin in young Kenyan infants (Publications)
dose, 5% (7/136) and 28% (35/123) of infants in OD and MD arms respectively had plasma gentamicin concentrations or =2 microg/ml (a surrogate of potential treatment toxicity) were found in 6% (5/89) and
Health-related quality of life, psychosocial work conditions, and absenteeism in an industrial sample of blue- and white-collar employees: a... (Publications)
manufacturing plant in Germany. Frequency indices were the number of sick-leave spells of 1, 2-3, 4-5, and > 5 days within 1 year. RESULTS/CONCLUSION: Effort-reward imbalance, lack of support by supervisors
Incidence of human granulocytic anaplasmosis in returning travelers with fever (Publications)
person-week of travel. The main destination of travel was Asia, accounting for 62.5% patients with HGA. Co-infections were found in 37.5% of patients with HGA. CONCLUSIONS: Diagnosis of HGA and empirical treatment
Health-related quality of life, psychosocial work conditions, and absenteeism in an industrial sample of blue- and white-collar employees: a... (Publications)
manufacturing plant in Germany. Frequency indices were the number of sick-leave spells of 1, 2-3, 4-5, and > 5 days within 1 year. RESULTS/CONCLUSION: Effort-reward imbalance, lack of support by supervisors
Optimization of potent inhibitors of <em>P. falciparum</em> dihydroorotate dehydrogenase for the treatment of malaria (Publications)
is for survival. We report herein the synthesis and structure-activity relationship of a series of 5-(2-methylbenzimidazol-1-yl)-N-alkylthiophene-2-carboxamides that are potent inhibitors against PfDHODH [...] potential drug-drug interactions, acceptable ADME/pharmacokinetic profile, and projected human dose, 5-(4-cyano-2-methyl-1H-benzo[d]imidazol-1-yl)-N-cyclopropylthiophene-2-carboxamide 2q was identified as
Efficacy of the diamidine DB75 and its prodrug DB289, against murine models of human African trypanosomiasis (Publications)
redress this situation, the recently synthesised diamidine, 2,5-bis(4-amidinophenyl)-furan (DB75, furamidine) and its methamidoxime prodrug, 2,5-bis(4-amidinophenyl)-furan-bis-O-methylamidoxime (DB289, p
Community transmission of SARS-CoV‑2 by surfaces: risks and risk reduction strategies (Publications)
hand-to-surface contact followed by hand-to-face contact range from 1.6×10−4 to 5.6×10−9 for modeled prevalencerates of 0.2%−5%. For observed prevalence rates (0.2%, 1%), this corresponds to a low risk of
A randomised, controlled trial of once daily and multi-dose daily gentamicin in young Kenyan infants (Publications)
dose, 5% (7/136) and 28% (35/123) of infants in OD and MD arms respectively had plasma gentamicin concentrations or =2 microg/ml (a surrogate of potential treatment toxicity) were found in 6% (5/89) and