Community transmission of SARS-CoV‑2 by surfaces: risks and risk reduction strategies (Publications)
hand-to-surface contact followed by hand-to-face contact range from 1.6×10−4 to 5.6×10−9 for modeled prevalencerates of 0.2%−5%. For observed prevalence rates (0.2%, 1%), this corresponds to a low risk of
A randomised, controlled trial of once daily and multi-dose daily gentamicin in young Kenyan infants (Publications)
dose, 5% (7/136) and 28% (35/123) of infants in OD and MD arms respectively had plasma gentamicin concentrations or =2 microg/ml (a surrogate of potential treatment toxicity) were found in 6% (5/89) and
Outcome of delivery and cause-specific mortality and severe morbidity in early infancy: a Kenyan District Hospital birth cohort (Publications)
were delivered. Of these, 136 (6%) were stillborn and 77 (3.5%) subsequently died. Prematurity (34%), birth asphyxia (27%), and infection (18.5%) were the predominant causes of death in the first 98 days
Optimization of potent inhibitors of <em>P. falciparum</em> dihydroorotate dehydrogenase for the treatment of malaria (Publications)
is for survival. We report herein the synthesis and structure-activity relationship of a series of 5-(2-methylbenzimidazol-1-yl)-N-alkylthiophene-2-carboxamides that are potent inhibitors against PfDHODH [...] potential drug-drug interactions, acceptable ADME/pharmacokinetic profile, and projected human dose, 5-(4-cyano-2-methyl-1H-benzo[d]imidazol-1-yl)-N-cyclopropylthiophene-2-carboxamide 2q was identified as
Antimalarial dibenzannulated medium-ring keto lactams (Publications)
keto lactams (11,12-dihydro-5H-dibenzo[b,g]azonine-6,13-diones) as a new antimalarial chemotype. Most of these had chromatographic LogD(7.4) values ranging from 100 μg/mL at pH 6.5). The more polar compounds
Incidence of human granulocytic anaplasmosis in returning travelers with fever (Publications)
person-week of travel. The main destination of travel was Asia, accounting for 62.5% patients with HGA. Co-infections were found in 37.5% of patients with HGA. CONCLUSIONS: Diagnosis of HGA and empirical treatment
Impact of the warm summer 2015 on emergency hospital admissions in Switzerland (Publications)
warmest regions (Ticino [8.4%, 95% CI 5.1-11.7%] and the Lake Geneva region [4.8%, 95% CI 3.0-6.7%]) and among the elderly population aged > /=75 years (5.1%, 95% CI 3.7-6.5%). Increased EHA during days with
<em>Staphylococcus aureus</em> in nasal lavage and biopsy of patients with chronic rhinosinusitis (Publications)
and fluorescence in situ hybridization. To assess the effects of S. aureus positivity, interleukin-5 (IL-5), interferon-gamma, total immunoglobulin E (IgE), eotaxin, granulocyte-colony stimulating factor [...] groups (P = 0.3). Staphylococcus aureus small colony variants were not found. In nasal lavages, IL-5 and total IgE levels were higher in CRSNP(+) patients than in CRSNP(-) patients or controls (P < 0.05)
Residential exposure to air pollution and incidence of leukaemia in the industrial area of Viadana, Northern Italy (Publications)
by age, between 1999 and 2014. We assigned estimated exposures to particulate matter (PM(10), PM(2.5)), nitrogen dioxide (NO(2)), and formaldehyde at residential addresses, averaged over the susceptibility [...] formaldehyde, and prior cancer diagnoses. RESULTS: There was no association of exposures to PM(10), PM(2.5), and NO(2) with leukaemia incidence. However, an indication of increased risk emerged for formaldehyde [...] formaldehyde were higher for acute (OR 2.07, 95%CI 0.70-6.12) and...
Human granulocytotropic anaplasmosis - a systematic review and analysis of the literature (Publications)
reported in a total of 40.5% of the reviewed cases and severe and even life-threatening complications are not infrequent (e.g. acute renal failure 9.8%, multi organ failure 7.5%, ARDS 6.3%, a.o.), sequelae [...] all continents except from Antarctica. HGA primarily presents as an unspecific febrile illness (88.5% of the cases) often accompanied by thrombocytopenia (71.8% of the cases), abnormal liver injury tests