Effectiveness of three sampling approaches for optimizing mapping and preventive chemotherapy against <em>Schistosoma mansoni</em> in the western part... (Publications)
d'Ivoire. The prevalence and intensity of Schistosoma mansoni infection were assessed in children aged 5-14 years using three sampling approaches. The first approach involved a random selection of 50% of the [...] villages selected by approach 2 in each health district. The overall prevalence of S. mansoni was 23.5% (95% confidence interval (CI): 19.9-27.6%), 21.6% (95% CI: 17.1-26.8%), and 18.3% (95% CI: 11.9-27 [...] stool (EPG) (95% CI: 109.3-127.3 EPG), 104.6 EPG (95% CI: 93.8-116.6 EPG),...
Recovery of left ventricular systolic function in peripartum cardiomyopathy: an observational study from rural Tanzania (Publications)
function (left ventricular ejection fraction > 50%). RESULTS: Median age of the 110 participants was 28.5 years (range 17-45). At enrolment, 49 (45%) participants were already on cardiac medication, 50 (45%) [...] left ventricular ejection fraction was 30% (range 15-46). After a median follow-up of 8.98 months (IQR 5.72-29.37), 61 (55%) participants were still on cardiac medication. Full recovery of the left ventricular [...] higher left ventricular ejection fraction at baseline was positively...
Screening a repurposing library, the Medicines for Malaria Venture Stasis Box, against <em>Schistosoma mansoni</em> (Publications)
highly active on adult worms in vitro (IC50 = 2.0-7.5 muM). IC50 values on adult S. mansoni decreased substantially in the presence of albumin (7.5-123.5 muM). Toxicity to L6 and MRC cells was moderate. A
Data-driven adult asthma phenotypes based on clinical characteristics are associated with asthma outcomes twenty years later (Publications)
to 7.8) and the regression estimates (95%CI) for FEV1% predicted varied from 0.6 (-3.5 to 4.6) to -9.9 (-14.2 to -5.5) between clusters. Change of FEV1 over time did not differ significantly across clusters
Antagonistic effects of <em>Plasmodium</em>-helminth co-infections on malaria pathology in different population groups in Côte d'Ivoire (Publications)
participants aged 5-16 years from a school-based study. CONCLUSIONS/SIGNIFICANCE: No exacerbation from co-infection with Plasmodium and helminths was observed, neither in participants aged 5-18 years nor in [...] of antagonistic nature but varied in magnitude and species combination. In study participants aged 5-18 years from community-based studies, Plasmodium-hookworm co-infection showed an antagonistic interaction
Antiprotozoal diterpenes from <em>Perovskia abrotanoides</em> (Publications)
IC50 of 2.9 microM (SI 19.2) against P. falciparum, and miltiodiol (10: ) with an IC50 of 0.5 microM (SI 10.5) against T. b. rhodesiense. None of the compounds exhibited selective toxicity against T. cruzi [...] -17: ), including 14 abietane-, two icetexane-, and one isopimarane-type derivatives. Among these, (5R,10S)-11-hydroxy-12-methoxy-20-norabieta-8,11,13-triene (2: ), 12-hydroxy-norabieta-1(10),8,11,13-tetraene-1
Pharmacokinetics of albendazole, albendazole sulfoxide and albendazole sulfone determined from plasma, blood, dried blood spots and Mitra® samples of... (Publications)
pamoate. Similar half-life (t1/2 approximately 1.5 h), time to reach the maximum concentration (tmax approximately 2 h) and maximum concentration (Cmax = 12.5-26.5 ng/mL) of albendazole were observed in the
ExpoApp: an integrated system to assess multiple personal environmental exposures (Publications)
level between ExpoApp and reference tools was 86.6% (86.5-86.7) and 75.7% (71.5-79.4), respectively. ExpoApp estimated that participants inhaled 16.5x10(10) particles/day of UFP and had almost no contact
Elemental composition of particulate matter and the association with lung function (Publications)
copper, iron, potassium, nickel, sulfur, silicon, vanadium, and zinc within PM smaller than 2.5 mum (PM2.5) and smaller than 10 mum (PM10) was estimated using land-use regression models. Associations between [...] differences in observed effect sizes between studies. METHODS:: We conducted a multicenter study in 5 European birth cohorts-BAMSE (Sweden), GINIplus and LISAplus (Germany), MAAS (United Kingdom), and PIAMA
Étude du biais dû aux non-répondants dans une étude épidemiologique (SAPALDIA) (Publications)
smoking is similar in R and NR except a higher frequency of wheezing during the last 12 month (R: 12.5%, NR: 5.6%, p = 0.03). The level of carbon monoxide in expired air is higher in NR (17.6 ppm) that in R [...] and R (24.8 ppm) among current smokers (p < 0.01). The main reasons for refusal are lack of time (27.5%), lack of interest for medical study (22.6%), fear of health professionals (18.3%) or the existence