Response of Kampuchean strains of <em>Plasmodium falciparum</em> to antimalarials: in-vivo assessment of quinine and quinine plus tetracycline;... (Publications)
asexual parasites per microliter of blood. With a dosage of 1.5 g quinine base daily for 10 days the average parasite clearance time was 5.6 days, and the average duration of fever 3.4 days. The in-vivo [...] averaged 11,393 asexual parasites per microliter of blood. The average parasite clearance time was 5.9 days, and the average duration of fever was 3.8 days. After 7 days of treatment, 81.8% of patients
The effect of air pollution on lung development from 10 to 18 years of age (Publications)
(P=0.005), acid vapor (P=0.004), particulate matter with an aerodynamic diameter of less than 2.5 microm (PM(2.5)) (P=0.04), and elemental carbon (P=0.007), even after adjustment for several potential confounders [...] expected FEV(1) of less than 80 percent) was 4.9 times as great at the highest level of exposure to PM(2.5) as at the lowest level of exposure (7.9 percent vs. 1.6 percent, P=0.002). CONCLUSIONS: The results
Rabies control in Liberia: joint efforts towards zero by 30 (Publications)
an accurately costed mass dog vaccination strategy were developed. Liberia is currently at stage 1.5/5 of the Stepwise Approach towards Rabies Elimination (SARE) tool, which corresponds with countries that [...] local-level interventions (e.g. dog vaccination campaigns) to the national level. Overall an estimated 5.3 - 8 million USD invested over 13 years is needed to eliminate rabies in Liberia by 2030. Liberia still
Microbial and chemical contamination of water, sediment and soil in the Nakivubo wetland area in Kampala, Uganda (Publications)
showed mean concentrations of TTCs of 2.9 x 10(5) colony-forming units (CFU)/100 mL. Mean E. coli was 9.9 x 10(4) CFU/100 mL. Hookworm eggs were found in 13.5 % of the water samples. Mean concentrations of [...] of iron (Fe), copper (Cu) and cadmium (Cd) were 21.5, 3.3 and 0.14 mg/L, respectively. In soil samples, we found a mean lead (Pb) concentration of 132.7 mg/L. In yams, concentrations of Cd, chromium (Cr)
Estimating the global burden of endemic canine rabies (Publications)
prophylaxis (PEP, 20%) and lost income whilst seeking PEP (15.5%), with only limited costs to the veterinary sector due to dog vaccination (1.5%), and additional costs to communities from livestock losses [...] CIs: 1.6-10.4 million) disability-adjusted life years (DALYs) and 8.6 billion USD (95% CIs: 2.9-21.5 billion) economic losses annually. The largest component of the economic burden is due to premature
Effect of single nucleotide polymorphisms in cytochrome P450 isoenzyme and N-acetyltransferase-2 genes on the metabolism of artemisinin-based... (Publications)
CYP2D6*10 (100C> T), CYP3A5*3, NAT2*6, and NAT2*7. In contrast, higher frequencies of mutant alleles were found in Tanzanians for CYP2D6*17 (1023C> T and 2850C> T), CYP3A4*1B, NAT2*5, and NAT2*14. In 8 SNPs [...] cytochrome P450 isoenzyme (CYP, namely CYP2A6, CYP2B6, CYP2C8, CYP2C9, CYP2C19, CYP2D6, CYP3A4, CYP3A5) and N-acetyltransferase-2 (NAT2) genes on the pharmacokinetics of artemisinin-based combination therapies
Childhood air pollutant exposure and carotid artery intima-media thickness in young adults (Publications)
(SD) increase in childhood (aged 0-5 years) or elementary school (aged 6-12) O(3) exposure was associated with a 7.8 mum (95% CI -0.3, 15.9) or 10.1 mum (95% CI 1.8, 18.5) higher CIMT, respectively. Lifetime [...] exposure to O(3) showed similar but non-significant associations. No associations were observed for PM(2.5), PM(10) or NO(2) although adjustment for these pollutants strengthened the childhood O(3) associations
Elemental composition of particulate matter and the association with lung function (Publications)
copper, iron, potassium, nickel, sulfur, silicon, vanadium, and zinc within PM smaller than 2.5 mum (PM2.5) and smaller than 10 mum (PM10) was estimated using land-use regression models. Associations between [...] differences in observed effect sizes between studies. METHODS:: We conducted a multicenter study in 5 European birth cohorts-BAMSE (Sweden), GINIplus and LISAplus (Germany), MAAS (United Kingdom), and PIAMA
Prevalence of drug-resistance mutations and HIV-1 subtypes in a HIV-1 infected COHORT in rural Tanzania (Publications)
The prevalence of major DR-SNPs in 2005-2007 in the RT gene was determined: K103N (5.0%), Y181C (2.5%), M184V (2.5%), G190A (1.7%) and M41L, K65KR, K70KR and L74LV (0.8%). In samples from 2009 only K103N
Impact of vaccines given during pregnancy on the offspring of women consulting a travel clinic: a longitudinal study (Publications)
range of 1 to 10 years. Rates of premature births were 5.7% in both groups; congenital abnormalities were 1.9% in the vaccinated cohort versus 5.7% in the nonvaccinated one; children took their first steps [...] steps at a median age of 12 months in both cohorts; among schoolchildren, 5% of the vaccinated cohort versus 7.7% of the nonvaccinated attended a lower level or a specialized school. CONCLUSION: In this
