Reaction hijacking of tyrosine tRNA synthetase as a new whole-of-life-cycle antimalarial strategy (Publications)
drug targets, and we present class I and II aaRSs as previously unrecognized targets for adenosine 5'-monophosphate-mimicking nucleoside sulfamates. The target enzyme catalyzes the formation of an inhibitory [...] inhibitory amino acid-sulfamate conjugate through a reaction-hijacking mechanism. We identified adenosine 5'-sulfamate as a broad-specificity compound that hijacks a range of aaRSs and ML901 as a specific reagent
Detection of mostly viral pathogens and high proportion of antibiotic treatment initiation in hospitalised children with community-acquired pneumonia... (Publications)
Fever (obligatory for enrolment) had been present for median 5 days before admission. Most common symptoms were reduced activity (129, 93.5%) and reduced oral intake (108, 78.3%). Oxygen saturation
Selektionierung von chloroquinresistenten <em>Plasmodium-falciparum</em>-Stämmen bei Touristen unter Chemoprophylaxe (Publications)
on. All 6 patients taking correct chloroquine prophylaxis (chloroquine plasma levels between 0.1-0.5 nmol/ml) harboured highly resistant P. falciparum strains (schizont maturation at 3.2 and 6.4 nmol/ml [...] strains were found only in patients with chloroquine plasma levels below 0.02 nmol/ml and in 4 of 5 patients who did not show chloroquine in the plasma. Selection of chloroquine-resistant P. falciparum
Premature atrial contractions in the general population: frequency and risk factors (Publications)
median (interquartile range) number of PACs per hour was 0.8 (0.4-1.8), 1.1 (0.5-2.4), 1.4 (0.7-4.6), 2.3 (0.8-6.9) and 2.6 (1.2-6.5) among participants aged 50-55, 55-60, 60-65, 65-70 and 70+ years, respectively
Patient-reported barriers to adherence to antiretroviral therapy: a systematic review and meta-analysis (Publications)
CI 20.1%-38.4%), being away from home (adults 30.4%, 95% CI 25.5%-35.2%; adolescents 40.7%, 95% CI 25.7%-55.6%; children/caregivers 18.5%, 95% CI 10.3%-26.8%), and a change to daily routine (adults 28 [...] reported as a barrier to adherence by more than 15% of patients across all age categories (adults 15.5%, 95% CI 12.8%-18.3%; adolescents 25.7%, 95% CI 17.7%-33.6%; children 15.1%, 95% CI 3.9%-26.3%), while [...] children across all regions (adults 13.6%, 95% CI 11.9%-15.3%;...
Measuring progress and projecting attainment on the basis of past trends of the health-related Sustainable Development Goals in 188 countries: an... (Publications)
We transformed each indicator on a scale of 0-100, with 0 as the 2.5th percentile estimated between 1990 and 2030, and 100 as the 97.5th percentile during that time. An index representing all 37 health-related [...] than 60% of countries projected to reach targets for under-5 mortality, neonatal mortality, maternal mortality ratio, and malaria, to less than 5% of countries projected to achieve targets linked to 11 indicator [...] and Afghanistan (10.9, 9.6-11.9), the Central African Republic...
Measuring progress and projecting attainment on the basis of past trends of the health-related Sustainable Development Goals in 188 countries: an... (Publications)
We transformed each indicator on a scale of 0-100, with 0 as the 2.5th percentile estimated between 1990 and 2030, and 100 as the 97.5th percentile during that time. An index representing all 37 health-related [...] than 60% of countries projected to reach targets for under-5 mortality, neonatal mortality, maternal mortality ratio, and malaria, to less than 5% of countries projected to achieve targets linked to 11 indicator [...] and Afghanistan (10.9, 9.6-11.9), the Central African Republic...
Patient-reported barriers to adherence to antiretroviral therapy: a systematic review and meta-analysis (Publications)
CI 20.1%-38.4%), being away from home (adults 30.4%, 95% CI 25.5%-35.2%; adolescents 40.7%, 95% CI 25.7%-55.6%; children/caregivers 18.5%, 95% CI 10.3%-26.8%), and a change to daily routine (adults 28 [...] reported as a barrier to adherence by more than 15% of patients across all age categories (adults 15.5%, 95% CI 12.8%-18.3%; adolescents 25.7%, 95% CI 17.7%-33.6%; children 15.1%, 95% CI 3.9%-26.3%), while [...] children across all regions (adults 13.6%, 95% CI 11.9%-15.3%;...
Low prevalence of <em>Plasmodium</em> and absence of malaria transmission in Conakry, Guinea: prospects for elimination (Publications)
Health statistical yearbooks was performed to determine malaria prevalence in children below the age of 5 years. RESULTS: Culex larval breeding sites were observed in large numbers throughout Conakry in both [...] remaining 10 (8.9 %) were An. melas. The molecular M form of An. gambiae s.s. was predominant (n = 89; 79.5 %). The proportions of kdr genotype in the An. gambiae s.s. M and S form were 65.2 and 81.8 % (n = 9) [...] detected in any of the mosquitoes tested. The prevalence of Plasmodium...
Efficacy and safety of oxantel pamoate in school-aged children infected with <em>Trichuris trichiura</em> on Pemba island, Tanzania: a parallel,... (Publications)
pamoate doses or the placebo. 5 mg/kg oxantel pamoate was the minimum effective dose (10 of 46 children cured [cure rate 22%, 95% CI 11-36]; egg-reduction rate 85·0%, 64·5-92·9). An increased probability [...] from any systematic illness. Children were randomly assigned to six different oxantel pamoate doses (5-30 mg/kg) or a placebo. Randomisation was stratified by baseline infection intensity using random block [...] pamoate 27 of 45 children were cured (cure rate 60%, 95% CI 44-65) with an...