Large-scale genome-wide association studies and meta-analyses of longitudinal change in adult lung function (Publications)
meta-analysis produced suggestive evidence for association at the novel IL16/STARD5/TMC3 locus on chromosome 15 (P = 5.71 x 10-7). In addition, meta-analysis using the five cohorts with > /=3 FEV1 measurements [...] associated with FEV1 decline in two additional cohort studies. We confirmed gene expression of IL16, STARD5, and ME3 in multiple lung tissues. Publicly available microarray data confirmed differential expression
Malaria vectors and their blood-meal sources in an area of high bed net ownership in the western Kenya highlands (Publications)
sensu stricto obtained blood-meals from humans, 26.5 % from goats and 18.4 % from bovines. Single blood-meal sources by An. gambiae s.s. from humans were 26.5 %, 8.2 % from bovines and 2.0 % from goats. Mixed [...] Mixed blood-meal sources by An. gambiae s.s. identified included: 24.5 % human/goat, 10.2 % human/bovine, 8.2 % human/bovine/goat and also 8.2 % bovine/goat. One An. arabiensis mosquito obtained blood-meal
Risk factors for Buruli ulcer in Ghana - a case control study in the Suhum-Kraboa-Coaltar and Akuapem south districts of the eastern region (Publications)
of wetland in the neighborhood (OR = 3.9, 95% CI = 1.9-8.2), insect bites in water/mud (OR = 5.7, 95% CI = 2.5-13.1), use of adhesive when injured (OR = 2.7, 95% CI = 1.1-6.8), and washing in the Densu river [...] District) diagnosed according to the WHO clinical case definition for BU and matched with age- (+/-5 years), gender-, and community controls. A structured questionnaire on host, demographic, environmental
Case-control study of individuals with discrepant nucleocapsid and spike protein SARS-CoV-2 IgG results (Publications)
[95% CI 72.1-92.5%] vs 94.7% [95% CI 85.4-98.9%]) but more specific (99.2% [95% CI 95.5-100%] vs 86.9% [95% CI 79.6-92.3%]) than anti-S1. Abbott anti-N sensitivity could be improved to 96.5% with minimal
SARS-CoV-2 nucleocapsid plasma antigen for diagnosis and monitoring of COVID-19 (Publications)
plasma samples. Median plasma antigen concentration (log10 fg/mL) was 5.4 (interquartile range 3.9-6.0) in outpatients, 6.0 (5.4-6.5) in inpatients, and 6.6 (6.1-7.2) in intensive care unit (ICU) patients
Skin wounds in a rural setting of Côte d'Ivoire: population-based assessment of the burden and clinical epidemiology (Publications)
furuncles (5.1%), burns (2.9%) and Buruli ulcer (2.2%). Most wounds were acute and smaller than 5 cm2 in size. 22.0% (176/799) of wounds showed evidence of secondary bacterial infection. 35.5% (22/62) of
Effect of lifting COVID-19 restrictions on utilisation of primary care services in Nepal: a difference-in-differences analysis (Publications)
s was associated with an average increase per palika of 57.5 contraceptive users (95% CI 14.6 to 100.5), 15.6 antenatal care visits (95% CI 5.3 to 25.9) and 1.6 child pneumonia visits (95% CI 0.2 to 2
Monitoring <em>Plasmodium falciparum</em> and <em>Plasmodium vivax</em> using microsatellite markers indicates limited changes in population structure... (Publications)
markers. Despite parasite prevalence declining substantially (East Sepik Province: Pf=54.9-8.5%, Pv=35.7-5.6%, Madang Province: Pf=38.0-9.0%, Pv: 31.8-19.7%), genetically diverse and intermixing parasite [...] remained high throughout the study period (East Sepik: Rs =11.4-9.3, He =0.83-0.80; Madang: Rs =12.2-14.5, He =0.85-0.88). Although genetic differentiation values increased between provinces over time, no
Antischistosomal, antionchocercal and antitrypanosomal potentials of some Ghanaian traditional medicines and their constituents (Publications)
the most promising results (IC50 = 5.63 mug/mL to 18.71 mug/mL). Incidentally, NTD-B4-DCM and NTD-B2-DCM, also exhibited the greatest antitrypanosomal activities (IC50 = 5.63 mug/mL and 7.12 mug/mL, respectively) [...] from traditional medicines used to treat schistosomiasis, displayed the highest activity (IC50 = 30.5 mug/mL and 30.8 mug/mL, respectively) against Schistosoma mansoni adult worms. NTD-B2-DCM, also obtained
Outdoor air pollution and hormone-assessed pubertal development in children: results from the GINIplus and LISA birth cohorts (Publications)
derived annual average concentrations of particulate matter with an aerodynamic diameter < 2.5 and 10 microm (PM2.5 and PM10), as well as spatial models assessed yearly average concentrations of nitrogen dioxide [...] 10. Overall, we found no statistically significant associations between exposure to particles (PM2.5 or PM10) and pubertal development. Results on NO2 and ozone were not significant as well; for instance