Particulate matter composition and respiratory health: the PIAMA birth cohort study (Publications)
potassium, nickel, sulfur, silicon, vanadium, and zinc in particles with diameters of less than 2.5 and 10 mum (PM2.5 and PM10) at birth addresses and current addresses from land-use regression models. Exposure-health [...] address. Forced expiratory volume in 1 second was negatively associated with copper and iron in PM2.5 (change [95% confidence interval] -2.1% [-1.1, -0.1%] and -1.0% [-2.0, -0.0%]) and FEF75-50 with copper
Family characteristics as risk factors for childhood acute lymphoblastic leukemia: a population-based case-control study (Publications)
We found that increasing maternal age was associated with incidence of ALL in the offspring (OR per 5-year increase in maternal age 1.18, 95% CI 1.05-1.31; p = 0.004), remaining stable (trend OR 1.14, 95% [...] 060) after adjustment for other risk factors. The association with paternal age was weaker (OR per 5-year increase 1.14, 95% CI 1.01-1.28, p = 0.032) and disappeared after adjustments. Number of older [...] years (OR per sibling 0.85, 95% CI 0.68-1.06; p = 0.141) and a positive trend for...
Comparative cost models of a liquid nitrogen vapor phase (LNVP) cold chain-distributed cryopreserved malaria vaccine vs. a conventional vaccine (Publications)
a tariff distribution system as occurs in Tanzania the FIC cost was $ 5.53. The models, therefore, predicted little difference in 5-year distribution costs between the PfSPZ vaccine distributed through [...] vaccines distributed through the Expanded Program on Immunization (EPI) use a 2-8°C cold chain with 4-5 stops. The PfSPZ vaccine comprises whole live-attenuated cryopreserved sporozoites stored in liquid
A randomised, single-blind, dose-range study to assess the immunogenicity and safety of a cell-culture-derived A/H1N1 influenza vaccine in adult and... (Publications)
s) adjuvant, 7.5mug antigen with a full dose of MF59, or a non-adjuvanted vaccine containing 15mug of antigen. Elderly (> /=61 years) subjects (n=268) received either the 3.75mug or 7.5mug adjuvanted [...] all three criteria in this age group. The highest antibody titres were observed in response to the 7.5mug vaccine containing a full dose of MF59 adjuvant. All subjects rapidly generated seroprotective antibody
A population-based study on the implementation of treatment recommendations for chemotherapy in early breast cancer (Publications)
receptor (ER) status (OR, 3.8; 95% CI, 2.6-5.5), human epidermal growth factor receptor 2 (HER2) status (OR, 1.9; 95% CI, 1.3-2.7), and patient age (OR, 4.6; 95% CI, 3.5-6.2) were less important predictors for
Case-control study of individuals with discrepant nucleocapsid and spike protein SARS-CoV-2 IgG results (Publications)
[95% CI 72.1-92.5%] vs 94.7% [95% CI 85.4-98.9%]) but more specific (99.2% [95% CI 95.5-100%] vs 86.9% [95% CI 79.6-92.3%]) than anti-S1. Abbott anti-N sensitivity could be improved to 96.5% with minimal
SARS-CoV-2 nucleocapsid plasma antigen for diagnosis and monitoring of COVID-19 (Publications)
plasma samples. Median plasma antigen concentration (log10 fg/mL) was 5.4 (interquartile range 3.9-6.0) in outpatients, 6.0 (5.4-6.5) in inpatients, and 6.6 (6.1-7.2) in intensive care unit (ICU) patients
Monitoring <em>Plasmodium falciparum</em> and <em>Plasmodium vivax</em> using microsatellite markers indicates limited changes in population structure... (Publications)
markers. Despite parasite prevalence declining substantially (East Sepik Province: Pf=54.9-8.5%, Pv=35.7-5.6%, Madang Province: Pf=38.0-9.0%, Pv: 31.8-19.7%), genetically diverse and intermixing parasite [...] remained high throughout the study period (East Sepik: Rs =11.4-9.3, He =0.83-0.80; Madang: Rs =12.2-14.5, He =0.85-0.88). Although genetic differentiation values increased between provinces over time, no
Antischistosomal, antionchocercal and antitrypanosomal potentials of some Ghanaian traditional medicines and their constituents (Publications)
the most promising results (IC50 = 5.63 mug/mL to 18.71 mug/mL). Incidentally, NTD-B4-DCM and NTD-B2-DCM, also exhibited the greatest antitrypanosomal activities (IC50 = 5.63 mug/mL and 7.12 mug/mL, respectively) [...] from traditional medicines used to treat schistosomiasis, displayed the highest activity (IC50 = 30.5 mug/mL and 30.8 mug/mL, respectively) against Schistosoma mansoni adult worms. NTD-B2-DCM, also obtained
Effect of lifting COVID-19 restrictions on utilisation of primary care services in Nepal: a difference-in-differences analysis (Publications)
s was associated with an average increase per palika of 57.5 contraceptive users (95% CI 14.6 to 100.5), 15.6 antenatal care visits (95% CI 5.3 to 25.9) and 1.6 child pneumonia visits (95% CI 0.2 to 2
