The association of LUR modeled PM2.5 elemental composition with personal exposure (Publications)
predicting personal exposures. In this study, the association of LUR modeled concentrations of PM2.5 components with measured personal concentrations was determined. The elements of interest were copper [...] sites were selected in each city (15 participants per city). Outdoor, indoor and personal 96-hour PM2.5 samples were collected by the participants over periods of two weeks in three different seasons (winter [...] with measured personal Cu exposure. After excluding observations with an...
Synthesis and testing of 5-benzyl-2,4-diaminopyrimidines as potential inhibitors of leishmanial and trypanosomal dihydrofolate reductase (Publications)
has not been thoroughly investigated in leishmania and trypanosomes. Work has previously shown that 5-benzyl-2,4-diaminopyrimidines are selective inhibitors of the leishmanial and trypanosome enzymes. Modelling [...] alkyl/aryl substitution on the 6-position of the pyrimidine ring should increase enzyme activity of 5-benzyl-2,4-diaminopyrimidines as inhibitors of leishmanial and trypanosomal dihydrofolate reductase
European Community Respiratory Health Survey II (ECRHS II) : final report of work package (WP 7) : assessment of chemical elements on PM2.5 collected... (Publications)
prognosis of respiratory diseases, in particular asthma and decline in lung function. We measured PM2.5 mass concentrations in 21 participating centres to estimate 'background' exposure in these cities, using [...] ns of mean values across all centres are presented. The availability of two centres in Antwerp, 11.5 km apart, provides the opportunity for an assessment of spatial variability of the elements. Most elements [...] However, patterns for some elements differ significantly from what we...
Synthesis and antitubulin activity of N1- and N4-substituted 3,5-dinitro sulfanilamides against African trypanosomes and Leishmania (Publications)
Thirty analogues of N(1)-phenyl-3,5-dinitro-N(4),N(4)-di-n-propylsulfanilamide (GB-II-5, compound 3), a new antikinetoplastid antimitotic agent, have been synthesized and evaluated. The addition of simple [...] antimitotic potency, but placement of a dibutyl substituent at the N4 nitrogen to give N(1)-phenyl-3,5-dinitro-N(4),N(4)-di-n-butylsulfanilamide (compound 35) augments antitrypanosomal and antileishmanial [...] vivo antitrypanosomal assays, the in vitro potency and selectivity of these...
Encouraging impact following 2.5 years of reinforced malaria control interventions in a hyperendemic region of the Republic of Guinea (Publications)
4-56.9 % in Guendembou) while increasing in the comparison sous-prefecture (64.5-69 %). It was consistently higher in children 5-14 years of age followed by those 1-59 months and > /=15 years. Indicators of
Patient-related risk factors leading to aseptic stem loosening in total hip arthroplasty: a case-control study of 5,035 patients (Publications)
BACKGROUND: We hypothesized that certain patient characteristics have different effects on the risk of early stem loosening in total hip arthroplasty (THA). We therefore conducted a case-control study
Synthesis and antiprotozoal activity of novel bis-benzamidino imidazo[1,2-a]pyridines and 5,6,7,8-tetrahydro-imidazo[1,2-a]pyridines (Publications)
bis-O-acetoxyamidoxime of 5a in glacial acetic acid gave the saturated analogue 2,6-bis[4-(amidinophenyl)]-5,6,7,8-tetrahydro-imidazo[1,2-a]pyridine 8. O-Methylation of the amidoximes 5a-d gave the N-methoxyamidines [...] 2-amino-5-bromopyridines to yield 3a-d. Suzuki coupling of 3a-d with 4-cyanophenylboronic acid yielded the 2,6-bis(4-cyanophenyl)-imidazo[1,2-a]pyridine derivatives 4a-d. The bis-amidoximes 5a-d, obtained