Prophylactic effect of artemether on human <em>Schistosomiasis mansoni</em> among Egyptian children: a randomized controlled trial (Publications)
PZQ twice four weeks apart, after which one group received 6mg/kg body weight of ART every 3 weeks in 5 cycles during the transmission season and the other group received ART-placebo. At the end of the study [...] o group, i.e. 6.7% versus 11.6%, and incidence of new infections for the PZQ/ART was 2.7% versus 6.5% for the PZQ/ART-placebo. In conclusion, PZQ/ART combined therapy might be considered as an adjunct
Antiprotozoal activity of (e)-cinnamic N-acylhydrazone derivatives (Publications)
azone derivatives, designed through molecular hybridization between the (E)-1-(benzo[d][1,3]dioxol-5-yl)-3-(4-bromophenyl)prop-2-en-1-one and (E)-3-hydroxy-N'-((2-hydroxynaphthalen-1-yl)methylene)-7-m [...] and bloodstream forms of Trypamosoma brucei rhodesiense. The derivative (2E)-3-(4-hydroxy-3-methoxy-5-nitrophenyl)-N'-[(1E)-phenylmethylene]acrylohydrazi de showed moderate antileishmanial activity (IC50
Cholesterol metabolites exported from human brain (Publications)
2-3mg/24h. Gas chromatography (GC)-MS data shows that the cholesterol metabolites 5alpha-hydroxy-6-oxocholesterol (3beta,5alpha-dihydroxycholestan-6-one), 7beta-hydroxycholesterol and 7-oxocholesterol, generally
Searching for new cures for tuberculosis: design, synthesis, and biological evaluation of 2-methylbenzothiazoles (Publications)
anti-TB agents. In this study, we report on the chemistry and biology of a series of potent 5-(2-methylbenzothiazol-5-yloxymethyl)isoxazole-3-carboxamide derivatives, which proved to be active against replicating
Unusual derivatives from <em>Hypericum scabrum</em> (Publications)
an unexpected cycloheptane ring decorated with prenyl substituents, and compound 3 has an unusual 5,5-spiroketal lactone core. Their structures were determined by extensive spectroscopic and spectrometric
Multiplicity and diversity of <em>Plasmodium vivax</em> infections in a highly endemic region in Papua New Guinea (Publications)
of the malaria cases in children less than 5 years of age. We collected 2117 blood samples at 2-monthly intervals from a cohort of 268 children aged 1 to 4.5 years and estimated the diversity and multiplicity
Exposure assessment to dust and free silica for workers of Sangan iron ore mine in Khaf, Iran (Publications)
Tappeh Ghermez drilling no. 1 at 66 +/- 13 and 1.5 +/- 0.4 mg/m(3), respectively, while the minimum concentrations were measured in pneumatic hammer at 5.26 +/- 3 and 0.01 +/- 0.005 mg/m(3), respectively
Associations between air pollution and socioeconomic characteristics, ethnicity and age profile of neighbourhoods in England and the Netherlands (Publications)
and elderly). We saw higher concentrations in the most deprived 20% of neighbourhoods in England (1.5 µg/m(3) higher PM10 and 4.4 µg/m(3) NO2). Concentrations in both countries were higher in neighbourhoods [...] (England: 3.0 µg/m(3) higher PM10 and 10.1 µg/m(3) NO2; the Netherlands: 1.1 µg/m(3) higher PM10 and 4.5 µg/m(3) NO2) after adjustment for urbanisation and other variables. Associations for some areas differed
Comparison of sensitivity and annoyance to road traffic and community noise between a South African and a Swiss population sample (Publications)
highly noise sensitive individuals (women: 35.1% vs 26.9%; men: 25% vs 20.5%) and people highly annoyed to road traffic noise (women: 20.5% vs 12.4%; men: 17.9% vs 11.1%) were observed in South Africa. While
Phytochemical study of <em>Salvia leriifolia</em> roots: rearranged abietane diterpenoids with antiprotozoal activity (Publications)
performed via extensive NMR and HRESIMS data, and the absolute configurations of compounds 1 and 3-5 were established by evaluation of experimental and calculated ECD spectra. The antiplasmodial activity [...] proposed. Leriifoliol (1) is the first 20- nor-9,10- seco-abietane, while 2 exhibits an uncommon 6-6-5 fused-ring system.