Public health impact and cost-effectiveness of the RTS,S/AS01 malaria vaccine: a systematic comparison of predictions from four mathematical models (Publications)
children. A positive impact is also predicted at a PfPR2-10 of 5-10%, but there is little impact at a prevalence of lower than 3%. At $5 per dose and a PfPR2-10 of 10-65%, we estimated a median incremental [...] trial data for follow-up of 32 months or longer to parameterise vaccine protection in the group aged 5-17 months. Estimates of cases, deaths, and disability-adjusted life-years (DALYs) averted were calculated [...] 2-10 year olds (PfPR2-10; range 3-65%). We considered two vaccine...
Adolescent transport and unintentional injuries: a systematic analysis using the Global Burden of Disease Study 2019 (Publications)
effects of medical treatment. From 1990 to 2019, global mortality rates declined by 34.4% (from 17.5 to 11.5 per 100 000) for transport injuries, and by 47.7% (from 15.9 to 8.3 per 100 000) for unintentional [...] nal injuries. However, in low-SDI nations the absolute number of deaths increased (by 80.5% to 42 774 for transport injuries and by 39.4% to 31 961 for unintentional injuries). In the high-SDI quintile [...] 838 in 2010 to 699 in 2019. This was a substantially slower pace of reduction...
Improve citizens’ access to Romanian quality health services in remote areas (Projects)
https://www.swisstph.ch/en/projects/project-detail/project/improve-citizens-access-to-romanian-quality-health-services-in-remote-areas
CHF 10 million from the Swiss side and a co-founding from the Romanian side of CHF 1.5 million (totalling CHF 11.5 million) to improve the citizen’s access to quality health services in remote areas of
<em>N</em>-substituted noscapine derivatives as new antiprotozoal agents: synthesis, antiparasitic activity and molecular docking study (Publications)
promising antiparasitic activity against Trypanosoma brucei rhodesiense with IC50 values between 2.5 and 10.0microM and selectivity index (SI) ranged from 0.8 to 13.2. Eight compounds exhibited activity [...] against Plasmodium falciparum K1 strain with IC50 ranging 1.7-6.4microM, and SI values between 2.8 and 10.5 against L6 rat myoblast cell lines. Molecular docking was carried out on trypanothione reductase (TbTR
Can the use of digital algorithms improve quality care? An example from Afghanistan (Publications)
understand if the adherence to the guidelines improved for a better quality of care for children under 5 years old. METHODS: More than one year after the introduction of digital algorithms, we carried out [...] consultation room and was based on the direct observation of 181 consultations of children aged 2 months to 5 years old, using a checklist completed by a senior physicians. The second survey queried 181 caretakers
Testing bio-efficacy of insecticide-treated nets with fewer mosquitoes for enhanced malaria control (Publications)
alternative protocol, using fewer mosquitos, while ensuring a precision in the main indicator of +/-5 percentage points (pp). We compared different laboratory methods against the probability of the LLIN [...] proportion of nets considered as valid was 0.40 pp. The 95% confidence interval of this value never exceed 5 pp when the number of LLIN tested was > /=40. This method slightly outperforms the current recommendations
Study of drug particle distributions within mini-tablets using synchrotron X-ray microtomography and superpixel image clustering (Publications)
with synchrotron phase contrast X-ray microtomography. Mini-tablets had a weight of 9.5 mg and a drug load from 2.5% to 20%. Moxidectin, a drug used for treatment of parasitic infections, was used as a
Implementing focused echocardiography and AI-supported analysis in a population-based survey in Lesotho: implications for community-based... (Publications)
confirmed by a cardiologist. Of the 126 not evaluable by the AI algorithm, 46 (36.5%) were manually evaluable. Overall, 660 (87.5%) uploaded files were evaluable and confirmed. Following short-term training
Antitrypanosomal isoflavan quinones from <em>Abrus precatorius</em> (Publications)
NOESY) spectroscopy. Abruquinones J (1), K (2), and L (3) were new, while abruquinones A (4) and D (5) were known from the first batch of plant material. The absolute configuration of compounds 1 to 3 was [...] comparison of electronic circular dichroism (ECD) spectra with calculated ECD data. Compounds 2 to 5 showed high in vitro activity against T. b. rhodesiense (IC50 of 0.01, 0.02, 0.02 and 0.01muM, respectively)
Men benefit more from midlife leisure-time physical activity than women regarding the development of late-life disability - results from the KORA-age... (Publications)
of physical activity and disability. RESULTS: We analysed 3333 persons with a mean follow-up of 18±5.5years. Using hurdle models, moderate activity and high activity had a protective effect on the occurrence