Chronic airflow obstruction in Tanzania - a cross-sectional study (Publications)
spirometric criteria, chronic airflow obstruction was found in n = 24 (4%, CI95 2.7-5.9) participants and in n = 30 (5%, CI95 3.5-7.1) applying GOLD spirometric criteria. To analyse risk factors for chronic airflow
Greywater recycling for diverse collection scales and appliances: enteric pathogen log-removal targets and treatment trains (Publications)
ter spp., viruses: rotavirus, norovirus, adenovirus, and Coxsackievirus B5) in the greywater streams for collection scales of 5-, 100-, and a 1000-people. Using quantitative microbial risk assessment (QMRA) [...] infections per person per year over 10'000 Monte Carlo iterations. LRTs were highest for norovirus at the 5-people scale and for adenovirus at the 100- and 1000-people scales. Example treatment trains were designed
Sonography to rule out tuberculosis in sub-Saharan Africa: a prospective observational study (Publications)
= 2.48; 95% CI, 1.52-5.03; P = .001 per degrees C increase) remained associated with tuberculosis. A combination of > /=1 FASH sign, abnormal chest x-ray, and temperature > /=37.5 degrees C had 99.1% [...] analyzed patients with a 6-month follow-up, 52.4% tested positive for human immunodeficiency virus, 21.5% had clinically suspected pulmonary tuberculosis, 3.7% had extrapulmonary tuberculosis, and 74.9% had
Effect of ambient air pollution on hospital admission for respiratory diseases in Hanoi children during 2007-2019 (Publications)
of hospital admissions per 10 μg/m(3) increase in daily average particulate matter (e.g. PM(1), PM(2.5), PM(10)), Sulfur Dioxide (SO(2)), Nitrogen Dioxide (NO(2)), 8-h maximum Ozone and per 1000 μg/m(3) [...] Hanoi by using the coefficient at lag 0. A 10 μg/m(3) increase in the concentration of PM(10), PM(2.5), PM(1), SO(2), NO(2), O(3) 8-h maximum and 1000 μg/m(3) increase in CO concentration was associated [...] upper respiratory diseases are related to increments in NO(2) and CO. For...
Prevalence of active convulsive epilepsy in sub-Saharan Africa and associated risk factors: cross-sectional and case-control studies (Publications)
between sites: 7.8 per 1000 people (95% CI 7.5-8.2) in Kilifi, 7.0 (6.2-7.4) in Agincourt, 10.3 (9.5-11.1) in Iganga-Mayuge, 14.8 (13.8-15.4) in Ifakara, and 10.1 (9.5-10.7) in Kintampo. The 1711 individuals
Sustaining control of schistosomiasis mansoni in western Côte d'Ivoire: results from a SCORE study, one year after initial praziquantel... (Publications)
and sustaining control of schistosomiasis and transitioning toward elimination. In Cote d'Ivoire, a 5-year cluster-randomized trial is being implemented in 75 schools to sustain the control of schistosomiasis [...] mansoni prevalence in the 75 schools surveyed at baseline was 22.1% (95% confidence interval (CI): 19.5-24.4%). The DOT coverage was 84.2%. In the 50 schools surveyed at baseline and one year after treatment [...] treatment, the overall prevalence of S. mansoni infection decreased...
Intestinal parasite infections and associated risk factors in communities exposed to wastewater in urban and peri-urban transition zones in Hanoi,... (Publications)
species (25 % and 5 %, respectively). Peri-urban farmers were at higher odds of infection with intestinal parasites than any other groups (adjusted odds ratio 5.8, 95 % confidence interval 2.5 to 13.7). Lack
Cardiovascular mortality and exposure to extremely low frequency magnetic fields: a cohort study of Swiss railway workers (Publications)
(median lifetime exposure 120.5 muT-years), and less or little exposed shunting yard engineers (42.1 muT-years), train attendants (13.3 muT-years) and station masters (5.7 muT-years). During 464,129 p [...] person-years of follow up, 5,413 deaths were recorded and 3,594 deaths were attributed to cardio-vascular diseases. We analyzed data using Cox proportional hazards models. RESULTS: For all cardiovascular
Identification of oleamide in <em>Guatteria</em> recurvisepala by LC/MS-Based <em>Plasmodium falciparum</em> thioredoxin reductase ligand binding... (Publications)
20-min gradient of 95 % B consisting of (A) 0.1 % formic acid in 95 % H (2)O-5 % ACN, and (B) 0.1 % formic acid in 95 % ACN-5% H (2)O in an LC-QTOF-MS. Tandem MS of the protonated molecule M/Z 282.2792 [...] ligand identified in the extract of GUATTERIA RECURVISEPALA displayed a relative binding affinity of 3.5-fold when incubated with 1 microM PFTrxR. The ligand corresponding to the protonated molecule M/Z 282
<em>In vitro</em> and<em> in vivo</em> activity of R- and S-praziquantel enantiomers and the main human metabolite trans-4-hydroxy-praziquantel... (Publications)
y. In vivo, R-PZQ was the most potent drug with worm burden reductions (WBRs) of 98.5, 75.6 and 73.3% at 125.0, 62.5 and 31.0 mg/kg, respectively. A single oral dose of 250.0 mg/kg PZQ resulted in a WBR [...] ED50 for R- and S-PZQ were 24.7 and 127.6 mg/kg, respectively, with a corresponding eudysmic ratio of 5.17. CONCLUSION: Our data support the theory of R-PZQ driving the antischistosomal activity. Interestingly