Synthesis and in vitro antiprotozoal activities of dicationic 3,5-diphenylisoxazoles (Publications)
3,5-bis(4-amidinophenyl)isoxazole (3)-an analogue of 2,5-bis(4-amidinophenyl)furan (furamidine) in which the central furan ring is replaced by isoxazole-and 42 novel analogues were prepared by two general
Novel dicationic imidazo[1,2-a]pyridines and 5,6,7,8-tetrahydro-imidazo[1,2-a]pyridines as antiprotozoal agents (Publications)
2-[5-(4-Amidinophenyl)-furan-2-yl]-5,6,7,8-tetrahydro-imidazo[1,2-a]pyridi ne-6-carboxamidine acetate salt (7) was synthesized from 2-[5-(4-cyanophenyl)-furan-2-yl]-imidazo[1,2-a]pyridine-6-carbonitrile [...] hyl acetate. N-Methoxy-2-(5-[4-(N-methoxyamidino)-phenyl]-furan-2-yl)-imidazo[1,2-a]pyr idine-6-carboxamidine (6) was prepared via methylation of the respective diamidoxime 5a with dimethyl sulfate. By [...] of 2-acetylfuran first with N-bromosuccinimide, and second with bromine to form...
Synthesis and antiparasitic evaluation of bis-2,5-[4-guanidinophenyl]thiophenes (Publications)
A series of bis-2,5-[4-guanidinophenyl]thiophenes were prepared in a five step process starting from 2,5-bis[trimethylstannyl]thiophene. The compounds were evaluated in vitro against Trypanosoma brucei
Sequelae of deep venous thrombosis, 5-year follow-up of 341 patients (Publications)
, either acute or sub-acute, were observed after 5 years... Or the 341 patients, 208 received streptokinase and 133 heparin. After the 5 years, 1 in 5 patients had developed CPT. The incidence of CPT was
Adenosine kinase of <em>T. b. Rhodesiense</em> identified as the putative target of 4-[5-(4-phenoxyphenyl)-2H-pyrazol-3-yl]morpholine using chemical... (Publications)
urgently needs novel targets and new efficacious chemotherapeutic agents. Recently, we discovered that 4-[5-(4-phenoxyphenyl)-2H-pyrazol-3-yl]morpholine (compound 1) exhibits specific antitrypanosomal activity
European community respiratory health survey II : final report of work package 5 : historic data of ambient air pollution in 37 European cities of... (Publications)
Starting in 2000, the adult population of 29 of the original 41 (mostly) European centres of the former ECRHS I cross-sectional study (1989-92) is being re- investigated in a cohort study. The primary
Examining the representativeness of home outdoor PM2.5, EC, and OC estimates for daily personal exposures in southern California (Publications)
diameter less than 2.5 ?m (PM(2.5)), elemental carbon (EC), and organic carbon (OC) during sixteen 10-day monitoring runs. Regression models to predict daily home outdoor PM(2.5), EC, and OC were constructed [...] variance explained (R(2)) was 0.97 and 0.94 for PM(2.5), 0.91 and 0.83 for OC, and 0.76 and 0.87 for EC in Riverside and Whittier, respectively. The PM(2.5) outdoor estimates correlated well with the personal [...] other pollutants. While home outdoor estimates provide good...
Evaluation of a sampling strategy for estimation of long-term PM2.5 exposure for epidemiological studies (Publications)
As part of the European Community Respiratory Health Survey (ECRHS) PM2.5 (particles collected with an upper 50% cut point of 2.5 microm aerodynamic diameter) was measured using an EPA-WINS (Environmental [...] the 'true' long-term averages, which were estimated using all available daily means. The daily PM2.5 means, obtained by both instruments operated in parallel, were only slightly different (the mean difference