Sustaining control of schistosomiasis mansoni in western Côte d'Ivoire: results from a SCORE study, one year after initial praziquantel... (Publications)
and sustaining control of schistosomiasis and transitioning toward elimination. In Cote d'Ivoire, a 5-year cluster-randomized trial is being implemented in 75 schools to sustain the control of schistosomiasis [...] mansoni prevalence in the 75 schools surveyed at baseline was 22.1% (95% confidence interval (CI): 19.5-24.4%). The DOT coverage was 84.2%. In the 50 schools surveyed at baseline and one year after treatment [...] treatment, the overall prevalence of S. mansoni infection...
Intestinal parasite infections and associated risk factors in communities exposed to wastewater in urban and peri-urban transition zones in Hanoi,... (Publications)
species (25 % and 5 %, respectively). Peri-urban farmers were at higher odds of infection with intestinal parasites than any other groups (adjusted odds ratio 5.8, 95 % confidence interval 2.5 to 13.7). Lack
Cardiovascular mortality and exposure to extremely low frequency magnetic fields: a cohort study of Swiss railway workers (Publications)
(median lifetime exposure 120.5 muT-years), and less or little exposed shunting yard engineers (42.1 muT-years), train attendants (13.3 muT-years) and station masters (5.7 muT-years). During 464,129 p [...] person-years of follow up, 5,413 deaths were recorded and 3,594 deaths were attributed to cardio-vascular diseases. We analyzed data using Cox proportional hazards models. RESULTS: For all cardiovascular
Identification of oleamide in <em>Guatteria</em> recurvisepala by LC/MS-Based <em>Plasmodium falciparum</em> thioredoxin reductase ligand binding... (Publications)
20-min gradient of 95 % B consisting of (A) 0.1 % formic acid in 95 % H (2)O-5 % ACN, and (B) 0.1 % formic acid in 95 % ACN-5% H (2)O in an LC-QTOF-MS. Tandem MS of the protonated molecule M/Z 282.2792 [...] ligand identified in the extract of GUATTERIA RECURVISEPALA displayed a relative binding affinity of 3.5-fold when incubated with 1 microM PFTrxR. The ligand corresponding to the protonated molecule M/Z 282
<em>In vitro</em> and<em> in vivo</em> activity of R- and S-praziquantel enantiomers and the main human metabolite trans-4-hydroxy-praziquantel... (Publications)
y. In vivo, R-PZQ was the most potent drug with worm burden reductions (WBRs) of 98.5, 75.6 and 73.3% at 125.0, 62.5 and 31.0 mg/kg, respectively. A single oral dose of 250.0 mg/kg PZQ resulted in a WBR [...] ED50 for R- and S-PZQ were 24.7 and 127.6 mg/kg, respectively, with a corresponding eudysmic ratio of 5.17. CONCLUSION: Our data support the theory of R-PZQ driving the antischistosomal activity. Interestingly
The use of routine health facility data for micro-stratification of malaria risk in mainland Tanzania (Publications)
period 2017-2019. The reported council-level prevalence classification in school children aged 5-16 years (PfPR(5-16)) was used as a benchmark to define four malaria risk groups. These groups were subsequently [...] into their overall risk stratum. RESULTS: Of 3065 wards, 353 were assigned to the very low strata (10.5% of the total ward population), 717 to the low strata (28.6% of the population), 525 to the moderate
Comparative assessment of insecticide resistance phenotypes in two major malaria vectors, <em>Anopheles funestus</em> and <em>Anopheles... (Publications)
funestus showed strong resistance to pyrethroids, surviving the 5x and 10x doses, while An. arabiensis reverted to susceptibility at the 5x dose. Pre-exposure to the synergist, piperonyl butoxide (PBO) [...] LLINs are widely used. METHODS: The study used the World Health Organization (WHO) assays with 1x, 5x and 10x insecticide doses to assess levels of resistance, followed by synergist bioassays to understand
Comparison of NO2 and BC predictions estimated using Google Street View-based and conventional European-wide LUR models in Copenhagen, Denmark (Publications)
segments and 0.40 at the residential level. The ratio of percentile 97.5 to 2.5 for NO2 across the study area streets using Google-MM NO2 was 4.5, while using EUW-LUR, this was 2.1. These NO2 ratios at residences
HIV care preferences among young people living with HIV in Lesotho: a secondary data analysis of the PEBRA cluster randomized trial (Publications)
compared to 8 of 123 (6.5%) after 12 months. Among those selecting clinic-based ART refill, many preferred collecting ART during the peer educator led Saturday clinic club, 45 of 123 (36.5%) at the beginning [...] at the end. SMS reminders for treatment adherence and ART refill visits were chosen by 51 of 123 (41.5%) at enrolment and 54 of 123 (44.7%) at the last assessment. Support by the peer educator was popular
Improving quality of medical certification of causes of death in health facilities in Tanzania 2014-2019 (Publications)
cause-specific mortality fractions due to unusable causes reduced from 27.4 to 13.5%. CONCLUSION: Data from less than 5% of annual deaths in Tanzania are usable for informing policy. For deaths with medical [...] MCCD ICD-10 codes were usable for health policy and planning, with no significant improvement over 5 years. Of certified deaths, 25% had unusable codes, 17% had insufficiently specified codes, and 6% were
