<em>Strongyloides stercoralis</em> infection and re-infection in a cohort of children in Cambodia (Publications)
per child. Complete data were available for 302 participants. We observed infections in 24.2% and 22.5% of the children at baseline and at follow-up, respectively. At baseline, 73 children were treated for [...] Infection and re-infection rates of S. stercoralis among schoolchildren are considerably high. However, 68.5% of infected children remained free of infection for at least two years. A large-scale cohort study
Ferrocenyl, ruthenocenyl, and benzyl oxamniquine derivatives with cross-species activity against <em>Schistosoma mansoni </em>and <em>Schistosoma... (Publications)
in mice. Subsequently, a ruthenocenyl (5) and a benzyl derivative (6) of OXA were synthesized to probe the importance of the ferrocenyl group in 1. Compounds 1, 5, and 6 were lethal to both S. mansoni and
Genetic diversity of <em>Mycobacterium tuberculosis</em> in Madang, Papua New Guinea (Publications)
tuberculosis were observed in 5.2% of isolates. Lineage 2 M. tuberculosis, which includes the 'Beijing' genotype, was significantly associated with any drug resistance (OR 5.2, 95%CI 1.8-15.1). Cluster analyses
Hepatitis-A-Ausbruch in einem Kindergarten (Publications)
Among 147 persons examined, 20 clinical cases of hepatitis A were diagnosed (9 adults, 11 children), 5 more children were unapparently infected. The hepatitis A virus was imported by an adult who contracted [...] phase, 11 persons were affected, 6 of them children from the kindergarten. The second phase involved 5 adults and another child from the kindergarten. The hygienic measures undertaken in the kindergarten
Prevalence and outcomes of hepatitis B coinfection and associated liver disease among antiretroviral therapy-naive individuals in a rural Tanzanian... (Publications)
associated with significant liver fibrosis (aspartate aminotransferase-to-platelet ratio index [APRI] > 1.5) and cirrhosis (APRI > 2.0) were identified using logistic regression. Results. Of 3097 individuals [...] antigen (HBsAg) positive. Before ART initiation, 9.1% individuals had significant liver fibrosis and 5.3% had cirrhosis. Human immunodeficiency virus/HBV-coinfected individuals were more likely to have an
Antiparasitic compounds from <em>Cupania cinerea</em> with activities against <em>Plasmodium falciparum</em> and <em>Trypanosoma brucei... (Publications)
moiety named cupacinoxepin (3), together with the known compounds scopoletin (4), caryophyllene oxide (5), two bisabolane sesquiterpenes (6 and 7), lichexanthone (8), gustastatin (9), lupenone (10), betulone [...] the P. falciparum K1 strain (IC(50)1, 1.3; 2, 1.8; and 3, 8.7 muM) and T. b. rhodesiense (IC(50)1, 4.5; 2, 15.8; and 3, 71.6 muM) were found. Cytotoxicity toward L-6 cells is discussed for all the compounds
Safety and immunogenicity of a three-component blood-stage malaria vaccine (MSP1, MSP2, RESA) against <em>Plasmodium falciparum</em> in Papua New... (Publications)
A phase I-IIb double-blind randomised placebo-controlled trial was undertaken in 120 children aged 5-9 years. Subjects were randomised in four groups: (i) No sulphadoxine-pyrimethamine (SP)+vaccine, (ii) [...] vaccine group where No SP had been given.Combination B proved to be safe and immunogenic in children aged 5-9 years. Vaccine immunogenicity was neither impaired by circulating parasites nor increased after p
Novel orally active antimalarial thiazoles (Publications)
activity in the P. berghei mouse model at 4 x 50 mg/kg administration via the oral route, showing 99.5% activity and 9 days survival and showed low in vitro cytotoxicity. Pharmacokinetic studies in rats [...] administration. Toward toxicity profiling, 3 exhibited moderate potential to inhibit CYP1A2 (IC(50) = 1.5 muM) and 2D6 (IC(50) = 0.4 muM) as well as having a potential hERG liability (IC(50) = 3.7 muM)
Effectiveness of a 10-day melarsoprol schedule for the treatment of late-stage human African trypanosomiasis: confirmation from a multinational study... (Publications)
patients were lost to follow-up. The overall fatality rate was 5.9%. Of treated patients, 8.7% had an encephalopathic syndrome that was fatal 45.5% of the time. The rate of severe bullous and maculopapular
Lufthygiene als Erfolgsfaktor (Page)
https://www.swisstph.ch/en/impact-stories/lufthygiene-als-erfolgsfaktor
langfristige Schadstoffbelastung mit Feinstaub (Partikel mit einem Durchmesser von 2,5 Mikrometern oder weniger PM 2,5 ) auf 5 μg/m3 pro Jahr zu reduzieren, jene mit NO 2 auf 10 μg/m3 und jene mit Ozon auf ein [...] die in der Schweiz heute geltenden Grenzwerte reduzieren (Grafik 2 bis 4 [5]). Grafik 2. Verlauf der Jahresmittel von Feinstaub PM2,5 an repräsentativen Standorten des NABEL-Messnetzes, verkehrsexponiert [...] Bundesamt für Umwelt (BAFU). Luft: Fachinformationen. Accessed 5.1.2022...