Comparison of the Paracheck-Pf test with microscopy, for the confirmation of <em>Plasmodium falciparum</em> malaria in Tanzania (Publications)
performance being relatively poor where the test had been stored for 12 months at room temperature (23.5+/-3.5 degrees C). The assay was easy to perform in the field and could clearly be a valuable tool in remote
Evaluation of GenoType((R)) MTBDRplus for the rapid detection of drug-resistant tuberculosis in Ghana (Publications)
using only MTBDRplus. RESULTS: Respectively 43 (8.2%) and 8 (1.5%) isolates were resistant to isoniazid (INH) and rifampicin (RMP), while 8 (1.5%) were multidrug-resistant. In resistant isolates, mutations
Challenges associated with management of Buruli ulcer/human immunodeficiency virus coinfection in a treatment center in Ghana: a case series study (Publications)
alone (2.5%; 279/11,125; P = 0.001). All seven BU/HIV-coinfected cases enrolled in the study presented with very large (category III) lesions with four having multiple lesions compared with 54.5% of category
Low risk for transmission of zoonotic <em>Giardia duodenalis</em> from dogs to humans in rural Cambodia (Publications)
characterisation of the glutamate dehydrogenase (gdh) gene placed 27.5% (11/40) of Giardia positive humans into assemblage AII and 72.5% (29/40) into assemblage BIII of G. duodenalis. In dogs, 20.0% (2/10)
Orally active antischistosomal early leads identified from the open access malaria box (Publications)
compounds were investigated in vivo. PRINCIPAL FINDINGS: Promising antischistosomal activity (IC50: 1.4-9.5 microM) was observed for 34 compounds against schistosomula. Three compounds presented IC50 values between [...] with a single oral 400 mg/kg dose of these drugs resulted in significant worm burden reductions of 52.5% and 40.8%, respectively. CONCLUSIONS/SIGNIFICANCE: The two candidates identified by investigating the
Do instructional videos on sputum submission result in increased tuberculosis case detection? A randomized controlled trial (Publications)
39.1 years (interquartile range 37.0-50.0); 94 (47%) were females, 106 (53%) were males, and 49 (24.5%) were HIV-infected. We found that the instructional video intervention was associated with detection [...] CI] 45.7-65.9%, sputum smear positive patients in the intervention group versus 23%, 95% CI 15.2-32.5%, in the control group, p /=3ml (78%, 95% CI 68.6-85.7%, versus 45%, 95% CI 35.0-55.3%, p
Predictors and overestimation of recalled mobile phone use among children and adolescents (Publications)
duration of calls was not significantly different for controls compared to cases (OR=1.1, 95%-CI: 0.5 to 2.5 and OR=1.9, 95%-CI: 0.85 to 4.3, respectively). However, likelihood to overestimate was associated
Antiprotozoal, antimycobacterial and cytotoxic potential of twenty-three British and Irish red algae (Publications)
rhodesiense, with Corallina officinalis and Ceramium virgatum being the most potent (IC(50) values 4.8 and 5.4 mug/ml), whilst none of the algal extracts inhibited the growth of T. cruzi. Except for Porphyra [...] extracts from all seaweeds also showed leishmanicidal activity with IC(50) values ranging from 16.5 to 85.6 mug/ml. Only the crude extract of Calliblepharis jubata showed some weak activity against M
Analysis of <em>Plasmodium falciparum</em> infections in a village community in Northern Nigeria: determination of msp2 genotypes and parasitespecific... (Publications)
of the rainy season, when transmission is high. We analysed blood samples from 104 individuals aged 5-70 years by polymerase chain reaction (PCR) amplifying the gene for the merozoite surface protein MSP2 [...] afterwards decreased significantly with age. Mean multiplicity in those 8-10-year-old children was 5.4 clones per carrier. Peak multiplicity and parasite diversity in Nigerian individuals is compared to
Prevalence and time course of acute mountain sickness in older children and adolescents after rapid ascent to 3450 meters (Publications)
which was reached through a 2.5-hour train ascent. RESULTS: We found that the overall prevalence of acute mountain sickness during the first 3 days at high altitude was 37.5%. Rates were similar for the