A call to strengthen the global strategy against schistosomiasis and soil-transmitted helminthiasis: the time is now (Publications)
for morbidity control of schistosomiasis and soil-transmitted helminthiasis, which affect more than 1.5 billion of the world's poorest people. Since then, more than a decade of research and experience has [...] population of sub-Saharan Africa will probably lose 2.3 million disability-adjusted life-years and US$3.5 billion of economic productivity every year, which is comparable to recent acute epidemics, including
<em>In vitro</em>, <em>ex vivo</em> and<em> in vivo</em> activity of diamidines against <em>Trypanosoma congolense</em> and <em>Trypanosoma vivax</em> (Publications)
using a single bolus dose for administration. Total cure in mice was seen at single i.p. doses of 5 and 2.5 mg/kg, for T. congolense- and T. vivax-infected mice, respectively. This study identified a selection
Development of land use regression models for elemental, organic carbon, PAH and hopanes/steranes in 10 ESCAPE/TRANSPHORM European study areas (Publications)
aromatic hydrocarbons (PAH), hopanes/steranes and elemental and organic carbon (EC/OC) content of PM2.5. In 10 European study areas PAH, hopanes/steranes and EC/OC concentrations were measured at 16-40 sites [...] The moderate to high explained variance of LUR models and the overall moderate correlation with PM2.5 model predictions support the application of especially the OC and PAH models in epidemiological studies
Gender differences in adult-onset asthma: results from the Swiss SAPALDIA cohort study (Publications)
confounders and stratified by sex and allergic sensitisation at baseline.Over 20 years, 128 (5.1%) men and 198 (7.5%) women newly reported doctor-diagnosed asthma. The adjusted odds ratio for female sex was
Effects of scale, question location, order of response alternatives, and season on self-reported noise annoyance using ICBEN scales: a field... (Publications)
of a balanced experimental design, the effect of type of annoyance question and corresponding scale (5-point verbal vs. 11-point numerical ICBEN (International Commission on Biological Effects of Noise) [...] 11-point numerical scale whereas the percentage of highly annoyed respondents was higher based on the 5-point scale, using common cutoff points. In conclusion, placement and presentation of annoyance questions
<em>SERPINA1</em> gene variants in individuals from the general population with reduced {alpha}1-antitrypsin concentrations (Publications)
Cohort Study on Air Pollution and Lung Diseases in Adults (SAPALDIA) with serum AAT concentrations 5 sequencing. RESULTS: We found that 900 of 1399 samples (64%), carried the normal PI*MM genotype, whereas [...] 103 to 113 and from 93 to 103 mg/dL, individuals with the PI*MM genotype represented the majority (86.5% and 53.8%, respectively). The PI*MS genotype was predominant (54.9%) in the AAT range of 83 to 93 mg/dL
1000 Genomes-based meta-analysis identifies 10 novel loci for kidney function (Publications)
association studies (GWAS) have revealed > 50 loci at which common variants with minor allele frequency > 5% are associated with kidney function. GWAS using more complete reference sets for imputation, such as [...] European ancestry participants using 1000 Genomes imputed data. We identified 10 novel loci with p-value < 5 x 10-8 previously missed by HapMap-based GWAS. Six of these loci (HOXD8, ARL15, PIK3R1, EYA4, ASTN2
Challenges associated with management of Buruli ulcer/human immunodeficiency virus coinfection in a treatment center in Ghana: a case series study (Publications)
alone (2.5%; 279/11,125; P = 0.001). All seven BU/HIV-coinfected cases enrolled in the study presented with very large (category III) lesions with four having multiple lesions compared with 54.5% of category
Prevalence and time course of acute mountain sickness in older children and adolescents after rapid ascent to 3450 meters (Publications)
which was reached through a 2.5-hour train ascent. RESULTS: We found that the overall prevalence of acute mountain sickness during the first 3 days at high altitude was 37.5%. Rates were similar for the
Predictors and overestimation of recalled mobile phone use among children and adolescents (Publications)
duration of calls was not significantly different for controls compared to cases (OR=1.1, 95%-CI: 0.5 to 2.5 and OR=1.9, 95%-CI: 0.85 to 4.3, respectively). However, likelihood to overestimate was associated