Trends of <em>Plasmodium falciparum</em> molecular markers associated with resistance to artemisinins and reduced susceptibility to lumefantrine in... (Publications)
falciparum multidrug resistance 1 (pfmdr1). RESULTS: Sequencing success was ≥ 87.8%, and 1,724/1,769 (97.5%) k13 wild-type samples were detected. Thirty-seven (2.1%) samples had synonymous mutations and only [...] samples carried N86 (wild-type), while mutations at Y184F increased from 33.9% in 2016 to about 60.5% in 2021, and only four samples (0.2%) had D1246Y mutations. pfmdr1 haplotypes were reported in 1,711 [...] sample, 0.1%). Between 2016 and 2021, NYD decreased from 66.1% to 45.2%,...
Patients with cystic echinococcosis in the three national referral centers of Mongolia: a model for CE management assessment (Publications)
treatment, surgery and watch & wait were 52.5% (95% CI 42-65), 25.8% (95% CI 15-30), 5.1% (95% CI 0-10) and 3.3% (95% CI 0.0-10), respectively. 13.3% (95% CI 5-25) of cysts were staged as CL and therefore
LEAPS-NCHD Program Evaluation (Projects)
https://www.swisstph.ch/en/projects/project-detail/project/leaps-nchd-program-evaluation
developed as a cross-generational strategy to support the learning and development of young children (3.5- to 5.5-year-olds) and female youth (18- to 24-year-olds). The program provides vocational training to female
External final evaluation of "Impact of air pollution on maternal and child health" project in Mongolia - 2018-2022 (Projects)
https://www.swisstph.ch/en/projects/project-detail/project/external-final-evaluation-of-impact-of-air-pollution-on-maternal-and-child-health-project-in-mongolia-2018-2022
public health crisis where every child and pregnancy is at risk. In winter months, the levels of PM2.5 pollution in Ulaanbaatar city (UB) can reach 1,985 micrograms per cubic meter — nearly 80 times the [...] found to have 40% lower lung function than children living in a rural area. In Ulaanbaatar (UB), a 3.5-fold increase in foetal deaths in the winter months has been documented. Preliminary analysis shows [...] impact level, the Project aims to contribute to: 1) reduced prevalence of...
Drug susceptibility testing and mortality in patients treated for tuberculosis in high-burden countries: a multicentre cohort study (Publications)
patients with tuberculosis were included in this analysis; the median age was 33.2 years (IQR 26.9-42.5), 239 (38%) were women, 272 (43%) were HIV-positive, and 69 (11%) patients died. Based on the reference [...] (62%) strains were pan-susceptible, 45 (7%) monoresistant, 163 (26%) multidrug-resistant (MDR), and 30 (5%) had pre-extensively or extensively drug resistant (pre-XDR or XDR) tuberculosis. Results of reference [...] discordant for 121 (19%) of 634. Overall, sensitivity to detect any...
Infant and child mortality in relation to malaria transmission in KEMRI/CDC HDSS, Western Kenya: validation of verbal autopsy (Publications)
malaria in VA. METHODS: Both all-cause, and cause-specific mortality reported by VA for children under 5 years of age, were assembled from the KEMRI/CDC health and demographic surveillance system in Siaya [...] deaths could be attributed to malaria by analysing the exposure-response relationship, though only 20.5% of VAs assigned malaria as the cause and the sensitivity of VAs was estimated to be only 26%. Although [...] significantly reduce malaria-diagnosed mortality, but also mortality...
Simulating the council-specific impact of anti-malaria interventions: a tool to support malaria strategic planning in Tanzania (Publications)
for meeting the national target at minimal costs, expected to reduce the prevalence by 77.5% (95%CI: 70.5%-84.5%) and to avert 102 million cases, with almost twice higher costs than those of the current
Investigation of antiplasmodial effects of terpenoid compounds isolated from myrrh (Publications)
lide (4: ), 2-methoxyisogermafurenolide (5: ), 8-epi-2-methoxyisogermafurenolide (6: ), furanodienone (7: ), 1(10)Z,4Z-furanodien-6-one (8: ), rel-2R-methyl-5S-acetoxy-4R-furanogermacr-1(10)Z-en-6-one [...] compounds were identified by MS and NMR spectroscopic analyses. To the best of our knowledge, compounds 5, 6, 12, 13, 16, 18: , and 20: are reported for the first time. All isolated compounds were tested in
Resurgence of HIV infection among men who have sex with men in Switzerland: mathematical modelling study (Publications)
infections and AIDS cases fitted the observed data well. By the end of 2010, an estimated 13.5% (95% CI 12.5, 14.6%) of all HIV-infected MSM were undiagnosed and accounted for 81.8% (95% CI 81.1, 82.4%) [...] infections and AIDS cases fitted the observed data well. By the end of 2010, an estimated 13.5% (95% CI 12.5, 14.6%) of all HIV-infected MSM were undiagnosed and accounted for 81.8% (95% CI 81.1, 82.4%)
Resurgence of HIV infection among men who have sex with men in Switzerland: mathematical modelling study (Publications)
infections and AIDS cases fitted the observed data well. By the end of 2010, an estimated 13.5% (95% CI 12.5, 14.6%) of all HIV-infected MSM were undiagnosed and accounted for 81.8% (95% CI 81.1, 82.4%) [...] infections and AIDS cases fitted the observed data well. By the end of 2010, an estimated 13.5% (95% CI 12.5, 14.6%) of all HIV-infected MSM were undiagnosed and accounted for 81.8% (95% CI 81.1, 82.4%)