Meta-analysis of dense genecentric association studies reveals common and uncommon variants associated with height (Publications)
surpassing the conventional genome-wide significance threshold (p < 5 x 10(-8)). Common variants with minor allele frequencies greater than 5% were observed to be associated with height in 37 previously reported
Trends and inequalities in cardiovascular disease mortality across 7932 English electoral wards, 1982-2006: Bayesian spatial analysis (Publications)
since the 1980s, but there are few data on small-area trends. We estimated CVD mortality by ward in 5-year intervals between 1982 and 2006, and examined trends in relation to starting mortality, region [...] death rates using a Bayesian spatial technique for all 7932 English electoral wards in consecutive 5-year intervals between 1982 and 2006, separately for men and women aged 30-64 years and > /=65 years
Changes in active and passive smoking in the European Community Respiratory Health Survey (Publications)
adjusted hazard risk ratio (HRR) or odds ratio (OR). The prevalence of active smoking declined by 5.9% (5.1-6.8) and exposure to passive smoking in nonsmokers declined by 18.4% (16.8-20.0). Subjects with
Discovery of dual function acridones as a new antimalarial chemotype (Publications)
administration, inexpensive synthesis and favourable physicochemical properties), our initial lead, T3.5 (3-chloro-6-(2-diethylamino-ethoxy)-10-(2-diethylamino-ethyl)-acridone), demonstrates unique synergistic [...] -like' chemosensitization to chloroquine and amodiaquine against quinoline-resistant parasites, T3.5 also results in an apparently mechanistically distinct synergism with quinine and with piperaquine.
Synthesis and antimalarial testing of neocryptolepine analogues: addition of ester function in SAR study of 2,11-disubstituted indolo[2,3-b]quinolines (Publications)
synthesis, and in vitro and in vivo antimalarial evaluations of certain ester-modified neocryptolepine (5-methyl-5H-indolo[2,3-b]quinoline) derivatives. The modifications were carried out by introducing ester groups
Psychiatric disorders, suicidality, and personality among young men by sexual orientation (Publications)
statistical significance, and the odds ratio for suicide attempt was halved (OR=5.10, 95% CI 2.57-10.1; AOR=2.42, 95% CI 1.16-5.02). There are noteworthy differences in personality traits by sexual orientation
Efficacy of moxidectin versus ivermectin against <em>Strongyloides stercoralis</em> infections: a randomized controlled non-inferiority trial (Publications)
compared to 95.2% (59/62) for ivermectin. Difference between CRs were estimated as -1.5%-pts (95% CI: -9.6 - 6.5), thus the lower limit of the CI exceeds the non-inferiority margin of 7%-pts. No side
Identification of a new locus at 16q12 associated with time-to-asthma onset (Publications)
performed by using survival analysis techniques. RESULTS: We detected 5 regions associated with TAO at the genome-wide significant level (P < 5 x 10-8). We evidenced a new locus in the 16q12 region (near cyl
Adult lung function and long-term air pollution exposure. ESCAPE: a multicentre cohort study and meta-analysis (Publications)
not other PM metrics (PM2.5, coarse fraction of PM, PM absorbance), was associated with a lower level of FEV1 (-44.6 mL, 95% CI -85.4- -3.8) and FVC (-59.0 mL, 95% CI -112.3- -5.6). The associations were
Developing human biomonitoring as a 21st century toolbox within the European exposure science strategy 2020-2030 (Publications)
exposure to multiple chemicals (mixtures); (4) bridging regulatory silos on aggregate exposure; and (5) enhancing the effectiveness of risk management measures. In this strategy paper we propose a vision [...] further development of quality control / quality assurance throughout the HBM research life cycle; 5) obtain sustained funding and reinforcement by legislation; and 6) extend target-specific communication
