Evolution and patterns of global health financing 1995-2014: development assistance for health, and government, prepaid private, and out-of-pocket... (Publications)
health spending growth rates were in upper-middle-income (5.9) and lower-middle-income groups (5.0), which both increased spending at more than 5% per year, and spent $914 and $267 per capita in 2014, r
Evaluation of tuberculosis diagnostic test accuracy using Bayesian latent class analysis in the presence of conditional dependence between the... (Publications)
screen for PTB: any TB symptom, radiologist conclusion, Computer Aided Detection for TB version 5 (CAD4TBv5> /=53), CAD4TBv6> /=53, Xpert Ultra (excluding trace) and culture. Before the application of our [...] CrI: 48.7, 74.4) and 75.9% (95% CrI: 61.9, 89.2), respectively. Any chest X-ray abnormality, CAD4TBv5> /=53 and CAD4TBv6> /=53 had similar overall sensitivity. Up to 73.3% (95% CrI: 61.4, 83.4) of all true
Discovery of FNDR-20123, a histone deacetylase inhibitor for the treatment of <em>Plasmodium falciparum</em> malaria (Publications)
s in rats at 100 mg/kg body weight shows good exposures (Cmax = 1.1 microM) and half-life (T1/2 = 5.5 h). Furthermore, a 14-day toxicokinetic study at 100 mg/kg daily dose did not show any abnormality [...] gametocytes, indicating a potential for transmission control: IC50 values being 190 nM for male and > 5 microM for female gametocytes. FNDR-20123 is a stable candidate in human/mouse/rat liver microsomes
Cross-reaction of POC-CCA urine test for detection of <em>Schistosoma mekongi</em> in Lao PDR: a cross-sectional study (Publications)
(predictors) with POC-CCA test results (outcome). RESULTS: In S. mekongi-endemic Champasack, 11.5% (n = 366) and 0.5% (n = 2) of study participants had positive POC-CCA and Kato-Katz test results, respectively [...] is not endemic, the POC-CCA test yielded (presumably) false positive results for 6.0% (n = 22) and 2.5% (n = 9) of study participants, respectively, while all of the Kato-Katz tests were negative. POC-CCA
Sexual and reproductive health services use among adolescents in pastoralist settings, northeastern Ethiopia (Publications)
through face-to-face interviews with a structured questionnaire; data entry was done with Epi info 3.5.1. Logistic regression analyses was used to assess associations with SRH service uptake. SPSS version [...] two-thirds or 513 (67%) of the respondents are aware of ASRH services. However, only one-fourth (24.5%) of the enrolled adolescents used at least one ASRH service in the past twelve months. ASRH services [...] associated with gender (being female [AOR = 1.87 (CI 1.29-2.70)], being in...
Role of human Pegivirus infections in whole <em>Plasmodium falciparum </em>sporozoite vaccination and controlled human malaria infection in African... (Publications)
prevalence of HPgV-1 was 29.2% (28/96) and sequence analysis of the 5' UTR and E2 regions revealed the predominance of genotypes 1, 2 and 5. HPgV-1 infection was associated with elevated systemic levels of [...] individuals. However, a tendency for higher protection levels was detected in the HPgV-1 positive group (62.5%) compared to the negative one (51.6%) following CHMI. HPgV-1 viremia levels were not significantly
COVID-19 pandemic and health related quality of life in primary school children in Switzerland: a repeated cross-sectional study (Publications)
2020, the first year of the COVID-19 pandemic. METHODS: The present study included 1,712 children aged 5 to 11 years who either participated in the baseline assessment of the SOPHYA cohort study in 2014/15 [...] .CONCLUSION: The SOPHYA-study showed that HRQoL, and especially emotional well-being, was lower in 5 to 11-year-old children in Switzerland during the first year of the pandemic compared to the results [...] CONCLUSION: The SOPHYA-study showed that HRQoL, and especially emotional...
Intestinal helminth infections and associated risk factors among adults in the Lao People's Democratic Republic (Publications)
participants were enrolled. Their average age was 46.0 years; 57.8% were female. Overall, 30.9%, 8.6% and 1.5% of study participants were infected with one, two, or three different intestinal helminth species, [...] viverrini-like (Ov-like) infection, 4.8% with Strongyloides stercoralis, 2.3% with Ascaris lumbricoides, 1.5% with Trichuris trichiura, and 3.3% with Taenia spp. Ov-like infection was of high prevalence in the [...] infected with hookworm [adjusted odds ratio (aOR) = 1.2, P = 0.019]....
Egg excretion indicators for the measurement of soil-transmitted helminth response to treatment (Publications)
22-45 days) after drug administration. PRINCIPAL FINDINGS: The 13 studies enrolled 5,759 STH stool-positive individuals; 5,688 received active medication or placebo contributing a total of 11,103 STH infections [...] tions 775 (23%). The overall mean ERR assessed by day 14-21 for albendazole and mebendazole was 94.5% and 87.4%, respectively on Ascaris lumbricoides, 86.8% and 40.8% on hookworm, and 44.9% and 23.8% on
Discovery of FNDR-20123, a histone deacetylase inhibitor for the treatment of <em>Plasmodium falciparum</em> malaria (Publications)
s in rats at 100 mg/kg body weight shows good exposures (Cmax = 1.1 microM) and half-life (T1/2 = 5.5 h). Furthermore, a 14-day toxicokinetic study at 100 mg/kg daily dose did not show any abnormality [...] gametocytes, indicating a potential for transmission control: IC50 values being 190 nM for male and > 5 microM for female gametocytes. FNDR-20123 is a stable candidate in human/mouse/rat liver microsomes