How urban characteristics affect vulnerability to heat and cold: a multi-country analysis (Publications)
Heat- and cold-related deaths amounted to 0.54% (95% confidence interval: 0.49 to 0.58%) and 6.05% (5.59 to 6.36%) of total deaths, respectively. Several city indicators modify the effect of heat, with [...] with a higher mortality impact associated with increases in population density, fine particles (PM2.5), gross domestic product (GDP) and Gini index (a measure of income inequality), whereas higher levels of
Global investment targets for malaria control and elimination between 2016 and 2030 (Publications)
Results: Annual investments of $6.4 billion (95% uncertainty interval (UI $4.5-$9.0 billion)) by 2020, $7.7 billion (95% UI $5.4-$10.9 billion) by 2025 and $8.7 billion (95% UI $6.0-$12.3 billion) by 2030
Multicountry distribution and characterization of extended-spectrum β-lactamase-associated gram-negative bacteria from bloodstream infections in... (Publications)
least one of the screened ESBL genes. Among specific Gram-negative isolates, 40 (45.5%) of 88 Klebsiella spp., 7 (5.7%) of 122 Escherichia coli, 6 (16.2%) of 37 Acinetobacter spp., and 2 (1.3%) of 159
Association between transportation noise and cardio-metabolic diseases: an update of the WHO meta-analysis (Publications)
Thirteen studies were included in the IHD meta-analysis, contributing 13 risk estimates for road traffic, 5 for aircraft and 3 for railway noise exposure. Only the result for road traffic noise reached statistical [...] significance (1.02 [1.00-1.04] per 10 dB Lden). For diabetes, 6 studies were included, contributing 5 risk estimates for road traffic, 3 for aircraft and 2 for railway noise exposure. Again, only the road
Investigating the drivers of the spatio-temporal patterns of genetic differences between <em>Plasmodium falciparum</em> malaria infections in Kilifi... (Publications)
geographic distance between parent and offspring malaria infections for the base model was 0.5 km (95% CI 0.3-1.5), for a distribution with 68% of distances shorter than the mean. Very short mean distances
Physical activity and dual disease burden among South African primary schoolchildren from disadvantaged neighbourhoods (Publications)
VD phenotype burden in South African schoolchildren. 801 children (402 boys, 399 girls; mean age 9.5years) from eight schools from disadvantaged neighbourhoods were included. Data assessment took place [...] (physically active on 6-7days/week for at least 60min), who were active, but below recommended standards (2-5 physically active days/week), or who were insufficiently active on almost all days (0-1 physically active
A genome-wide association study on medulloblastoma (Publications)
associated with increased medulloblastoma risk (p < 1 x 10(-5)), but none were statistically significant after adjusting for multiple testing (p < 5 x 10(-8)). Thirteen of these variants were genotyped, whereas
Molecular characterization, toxin detection and resistance testing of human clinical <em>Clostridium difficile </em>isolates from Lebanon (Publications)
testing. Ribotype 014 (RT014, 16.8%) predominated, followed by RT002 (9.3%), RT106 (8.4%) and RT070 (6.5%). Binary toxin gene-positive isolates (RT023, RT078 and RT126) were rarely detected and RT027 was absent [...] small proportion of strains displayed resistance against moxifloxacin, rifampicin, and clarithromycin (5.6%, 1.9%, and 2.8%), respectively. The data indicate that the genetic strain composition of Lebanese
Whole genome sequencing for drug resistance profile prediction in<em> Mycobacterium tuberculosis</em> (Publications)
73-99 % of cases, depending on the drug. Our data suggests that the established critical concentration (5 mg/L) for ethambutol resistance (MGIT 960 system) is too high and may misclassify strains as susceptible [...] resistance mechanisms. The overall sensitivity and specificity of whole genome-based DST were 86.8 % and 94.5 %, respectively.Despite some limitations, whole genome sequencing has the potential to infer resistance
Impact of adolescents' screen time and nocturnal mobile phone-related awakenings on sleep and general health symptoms: a prospective cohort study (Publications)
their own mobile phone per month were more likely to have developed restless sleep (Odds Ratio (OR): 5.66, 95% Confidence Interval: 2.24(-)14.26) and problems falling asleep (3.51, 1.05(-)11.74) within one [...] ty (1.76, 1.02(-)3.03), lack of energy (1.76, 1.04(-)2.96) and lack of concentration (2.90, 1.55(-)5.42). Our results suggest a detrimental effect of screen time and mobile phone-related awakenings on