Seasonal pattern of <em>Mycobacterium ulcerans</em>, the causative agent of Buruli ulcer, in the environment in Ghana (Publications)
of MU along the Densu River basin was 89/434 (20.5 %), whilst that of the Offin River basin was 50/1166 (4.3 %). The DNA was detected mainly in snails (5/6, 83 %), moss (8/40, 20 %), soil (55/586, 9 %)
Pharmacokinetics, <em>Trypanosoma brucei gambiense</em> efficacy and time of drug action of DB829, a preclinical candidate for treatment of second... (Publications)
against the T. b. rhodesiense STIB900 strain. A single dose of DB829 administered intraperitoneally (5 mg/kg) cured all mice infected with different T. b. gambiense strains. No cross-resistance was observed [...] dose of DB829 (20 mg/kg) administered intraperitoneally clears parasites from mouse blood within 2-5 days. In summary, DB829 is a promising preclinical candidate for the treatment of first and second stage
Pharmacokinetics of the antischistosomal lead ozonide OZ418 in uninfected mice determined by liquid chromatography-tandem mass spectrometry (Publications)
validated following USFDA guidelines. This method proved to be selective, accurate (93-103%), precise (5-16%), devoid of significant matrix effects (90-102%) and provided an excellent recovery (101-102%). [...] pooled non-compartmental PK analysis estimated a mean area under the curve (AUC) of 9303 (7039.2-11908.5) mug h/mL and a half-life of 38.7 (20-64.6) h. Thus the OZ418 level in plasma remained well above its
Regular family breakfast was associated with children's overweight and parental education: results from the ENERGY cross-sectional study (Publications)
This study aims to assess (i) the prevalence of having regular family breakfast, lunch, dinner (i.e. 5-7days/week together with their family) among 10-12year olds in Europe, (ii) the association between [...] residence, gender, ethnicity and parental levels of education. METHODS: 7716 children (mean age: 11.5+/-0.7years, 52% girls) in eight European countries (Belgium, Greece, Hungary, The Netherlands, Norway
Health-related quality of life in South African patients with pulmonary tuberculosis (Publications)
study during six-month standard TB treatment in South Africa. These included the generic SF-12 and EQ-5D-5L, the disease-specific St. George s Respiratory Questionnaire (SGRQ) and the condition-specific Hospital
Diagnosis of soil-transmitted helminths in the era of preventive chemotherapy: effect of multiple stool sampling and use of different diagnostic... (Publications)
observed prevalences for T. trichiura, hookworm, A. lumbricoides, and S. stercoralis were 47.9%, 22.5%, 16.5%, and 10.8% after examining 3 stool samples. These values are close to the 'true' prevalences predicted
Symptoms and cognitive functions in adolescents in relation to mobile phone use during night (Publications)
for daytime tiredness and rapid exhaustibility were 1.86 (95% CI: 1.02-3.39) and 2.28 (95% CI: 0.97-5.34), respectively. Similar results were found when analyzing objective operator recorded mobile phone [...] phone use data (tiredness: 1.63, 95% CI: 0.94-2.82 and rapid exhaustibility: 2.32, 95% CI: 1.01-5.36). The cognitive tests on memory and concentration capacity were not related to mobile phone use during
<em>Plasmodium vivax</em> diversity and population structure across four continents (Publications)
South Pacific (8.1-9.9) Madagascar and Sudan (7.9-8.4), and lowest in South America and Central Asia (5.5-7.2). A reduced panel of only 3 markers was sufficient to identify approx. 90% of all haplotypes in
Prévalence, diversité antigénique et multiplicité d'infections de <em>Plasmodium falciparum</em> en milieu scolaire au centre de la Côte... (Publications)
light microscopy and polymerase chain reaction (PCR). A total of 424 schoolchildren ranging in age from 5 to 15 years underwent diagnostic testing using both light microscopy of blood smears and PCR. Multiplicity [...] the restriction fragment of the gene encoding the merozoite surface protein-2 (msp2) showed that 86.5% of cases involved multiple infection with a geometric mean of 3.87 genotypes per positive child. There
Spatial dispersion and characterisation of mosquito breeding habitats in urban vegetable-production areas of Abidjan, Côte d'Ivoire (Publications)
surveys, respectively. In the rainy season, Anopheles larvae and mosquito pupae were found in 29.7% and 5.5% of the potential breeding sites, respectively, whereas the corresponding percentages in the dry season