Air pollution and childhood leukaemia: a nationwide case-control study in Italy (Publications)
length of main roads within 100 m) and estimates of pollutants concentrations (particulate matter -PM2.5 and PM10- and gases -NO2 and O3-) from national dispersion model and land use regression models. The [...] controls lived along busy roads, and the mean annual PM10 levels were 33.3 (SD=6.3) and 33.4 µg/m3 (SD=6.5), respectively. No association was found, and all ORs, independent of the method of assessment and the
Can school-based distribution be used to maintain coverage of long-lasting insecticide treated bed nets: evidence from a large scale programme in... (Publications)
and distributed one LLIN to each enrolled child attending schools in primary grades (standards) 1, 3, 5 and 7, and secondary grades (forms) 2 and 4 in 2013 and again with slightly modified eligibility criteria [...] , ownership of at least one LLIN had dropped significantly in the control area to 65.4% (95% CI 59.5-71.0) in 2015 (P < 0.001), while coverage in the intervention area was maintained at 79.3% (95% CI 75
Seasonal pattern of <em>Mycobacterium ulcerans</em>, the causative agent of Buruli ulcer, in the environment in Ghana (Publications)
of MU along the Densu River basin was 89/434 (20.5 %), whilst that of the Offin River basin was 50/1166 (4.3 %). The DNA was detected mainly in snails (5/6, 83 %), moss (8/40, 20 %), soil (55/586, 9 %)
Investigating the drivers of the spatio-temporal patterns of genetic differences between <em>Plasmodium falciparum</em> malaria infections in Kilifi... (Publications)
geographic distance between parent and offspring malaria infections for the base model was 0.5 km (95% CI 0.3-1.5), for a distribution with 68% of distances shorter than the mean. Very short mean distances
Pharmacokinetics, <em>Trypanosoma brucei gambiense</em> efficacy and time of drug action of DB829, a preclinical candidate for treatment of second... (Publications)
against the T. b. rhodesiense STIB900 strain. A single dose of DB829 administered intraperitoneally (5 mg/kg) cured all mice infected with different T. b. gambiense strains. No cross-resistance was observed [...] dose of DB829 (20 mg/kg) administered intraperitoneally clears parasites from mouse blood within 2-5 days. In summary, DB829 is a promising preclinical candidate for the treatment of first and second stage
Safety and differential antibody and T-cell responses to <em>Plasmodium falciparum</em> sporozoite vaccine by age in Tanzanian adults, adolescents,... (Publications)
vaccinees and controls or between dosage regimens. Because all age groups received three doses of 9.0 x 10(5) PfSPZ of PfSPZ Vaccine, immune responses were compared at this dosage. Median antibody responses against [...] infants and lowest in adults. T-cell responses were highest in 6-10-year olds after one dose and 1-5-year olds after three doses; infants had no significant positive T-cell responses. The safety data were
Regular family breakfast was associated with children's overweight and parental education: results from the ENERGY cross-sectional study (Publications)
This study aims to assess (i) the prevalence of having regular family breakfast, lunch, dinner (i.e. 5-7days/week together with their family) among 10-12year olds in Europe, (ii) the association between [...] residence, gender, ethnicity and parental levels of education. METHODS: 7716 children (mean age: 11.5+/-0.7years, 52% girls) in eight European countries (Belgium, Greece, Hungary, The Netherlands, Norway
Pharmacokinetics of the antischistosomal lead ozonide OZ418 in uninfected mice determined by liquid chromatography-tandem mass spectrometry (Publications)
validated following USFDA guidelines. This method proved to be selective, accurate (93-103%), precise (5-16%), devoid of significant matrix effects (90-102%) and provided an excellent recovery (101-102%). [...] pooled non-compartmental PK analysis estimated a mean area under the curve (AUC) of 9303 (7039.2-11908.5) mug h/mL and a half-life of 38.7 (20-64.6) h. Thus the OZ418 level in plasma remained well above its
<em>Plasmodium vivax</em> diversity and population structure across four continents (Publications)
South Pacific (8.1-9.9) Madagascar and Sudan (7.9-8.4), and lowest in South America and Central Asia (5.5-7.2). A reduced panel of only 3 markers was sufficient to identify approx. 90% of all haplotypes in
Whole genome sequencing for drug resistance profile prediction in<em> Mycobacterium tuberculosis</em> (Publications)
73-99 % of cases, depending on the drug. Our data suggests that the established critical concentration (5 mg/L) for ethambutol resistance (MGIT 960 system) is too high and may misclassify strains as susceptible [...] resistance mechanisms. The overall sensitivity and specificity of whole genome-based DST were 86.8 % and 94.5 %, respectively.Despite some limitations, whole genome sequencing has the potential to infer resistance
