Pharmacokinetics, <em>Trypanosoma brucei gambiense</em> efficacy and time of drug action of DB829, a preclinical candidate for treatment of second... (Publications)
against the T. b. rhodesiense STIB900 strain. A single dose of DB829 administered intraperitoneally (5 mg/kg) cured all mice infected with different T. b. gambiense strains. No cross-resistance was observed [...] dose of DB829 (20 mg/kg) administered intraperitoneally clears parasites from mouse blood within 2-5 days. In summary, DB829 is a promising preclinical candidate for the treatment of first and second stage
Diagnosis of soil-transmitted helminths in the era of preventive chemotherapy: effect of multiple stool sampling and use of different diagnostic... (Publications)
observed prevalences for T. trichiura, hookworm, A. lumbricoides, and S. stercoralis were 47.9%, 22.5%, 16.5%, and 10.8% after examining 3 stool samples. These values are close to the 'true' prevalences predicted
Geneva Health Forum Events with Swiss TPH (Page)
https://www.swisstph.ch/en/about/events/ghf-events
[overview] 5 minutes [LAP] Central African Region case study (pre-recorded according to need): Overview of the programme: 5 minutes [BS or colleague from OCEAC] Perspective of PhD supervisors: 5 minutes [AAA] [...] minutes in total: 5 minutes introduction, 25 minutes case-studies, 30 minutes panel discussion Ethiopia case study (pre-recorded according to need): The research [design, findings, implications] 5 minutes [DB] [...] Environmental Emergency: Reinventing Global Health in Times of Global...
Gesundheitsfolgenabschätzung (Page)
https://www.swisstph.ch/en/projects/ludok/aktuelle-berichte/gesundheitsfolgenabschaetzung
Luftverschmutzung mit PM2.5 und NO2 nach den aktuellem Wissensstand. Als gesundheitliche Zielgrössen wurden daher neben der Sterblichkeit zusätzlich 14 Krankheitsbilder, welche durch PM2.5 und NO2 verursacht [...] werden, untersucht. Mit der Einhaltung der WHO-Richtwerte von PM2.5 und NO2 in der Schweiz würden über 3300 vorzeitige Todesfälle und 3400 Asthmaerkrankungen im Vergleich zu den derzeit gültigen Werten [...] Raumentwicklung ARE finden sich die Kosten und Nutzen des Verkehrs für das...
Novel inhibitors of Trypanosoma cruzi dihydrofolate reductase (Publications)
homology model of the enzyme was used to search the Cambridge Structural Database using the program DOCK 3.5. Compounds were then tested against the enzyme and the whole parasite. Compounds were also screened
Insect-specific production of new GameXPeptides in <em>Photorhabdus luminescens</em> TTO1, widespread natural products in entomopathogenic bacteria (Publications)
the production medium. Here, we describe the insect-specific production of the new GameXPeptides E-H (5-8) from Photorhabdus luminescens TTO1, which can be produced heterologously from expression of the
Bronchial hyperresponsiveness and the development of asthma and COPD in asysmptomatic individuals - SAPALDIA cohort study (Publications)
methacholine were evaluated in 7,126 of the 9,651 SAPALDIA cohort study participants. Eleven years later, 5,825 of these participants were re-evaluated of whom 4,852 had spirometry. COPD was defined as FEV1/FVC
Actinoallolides A-E, new anti-trypanosomal macrolides, produced by an endophytic actinomycete, <em>Actinoallomurus fulvus</em> MK10-036 (Publications)
Five new anti-trypanosomal macrolides, actinoallolides A-E (1-5), were discovered from the cultured broth of Actinoallomurus fulvus MK10-036. The structures of the actinoallolides, including absolute
Insect-specific production of new GameXPeptides in <em>Photorhabdus luminescens</em> TTO1, widespread natural products in entomopathogenic bacteria (Publications)
the production medium. Here, we describe the insect-specific production of the new GameXPeptides E-H (5-8) from Photorhabdus luminescens TTO1, which can be produced heterologously from expression of the
Actinoallolides A-E, new anti-trypanosomal macrolides, produced by an endophytic actinomycete, <em>Actinoallomurus fulvus</em> MK10-036 (Publications)
Five new anti-trypanosomal macrolides, actinoallolides A-E (1-5), were discovered from the cultured broth of Actinoallomurus fulvus MK10-036. The structures of the actinoallolides, including absolute