Boosting effect of IL-7 in interferon gamma release assays to diagnose <em>Mycobacterium tuberculosis</em> infection (Publications)
higher release of IFN-gamma in individuals with active TB from 4.2IU/ml (IQR 1.4-6.9IU/ml) to 5.1IU/ml (IQR 1.5-8.1IU/ml, p = 0.0057), and we found an indication of a lower release of both IFN-gamma and IP-10
Incidence trends of airflow obstruction among European adults without asthma: a 20-year cohort study (Publications)
ator AO (AOpost-BD), which is the primary characteristic of COPD. AO incidence was 4.4 (95% CI: 3.5-5.3) male and 3.8 (3.1-4.6) female cases/1,000/year. Among ever smokers (median pack-years: 20, males;
Human African trypanosomiasis (Publications)
very advanced cases. The treatment-related mortality rate consequently dropped from 5% with melarsoprol to around 0.5%. A single-dose oral treatment, acoziborole, has completed Phase III trials and may
HPLC-based activity profiling for antiplasmodial compounds in the traditional Indonesian medicinal plant <em>Carica papaya</em> L (Publications)
HPLC-MS and MPLC-ELSD. Structures were established by HR-ESI-MS and NMR spectroscopy. For compounds 5 and 7 absolute configuration was confirmed by comparison of experimental and calculated electronic circular [...] nicotiflorin. Five compounds isolated from the alkaloidal fraction were piperidine alkaloids. Compounds 5 and 6 were inactive carpamic acid and methyl carpamate, while three alkaloids 7-9 showed high antiplasmodial
Mental health litaracy and the experience of depression in a community sample of gay men (Publications)
greater susceptibility among gay men, yet men with MDD reported problems with love/relationship (32.5%) and work (28.9%) as the most common perceived causes of recent depression, and problems with love [...] such as a close friend (91.6%), relaxation exercises or meditation (84.4%), and physical activity (83.5%) as being helpful for the depression vignette. LIMITATIONS: No probes used for open questions, and
Integration of genome-wide association studies with biological knowledge identifies six novel genes related to kidney function (Publications)
replication. Among samples of European ancestry, we identified a genome-wide significant SNP in FBXL20 (p=5.6x10(-9)) in meta-analysis of all available data, and additional SNPs at the INHBC, LRP2, PLEKHA1, SLC3A2 [...] SLC7A6 genes meeting multiple-testing corrected significance for replication and overall p-values of 4.5x10(-4)-2.2x10(-7). Neither the novel PLEKHA1 nor FBXL20 associations, both further supported by association
Menopause is associated with accelerated lung function decline (Publications)
was increased by -10.2 ml/yr (95% Confidence interval -13.1 to -7.2) in transitional women and -12.5 ml/yr (-16.2 to -8.9) in postmenopausal women, compared to women menstruating regularly. The adjusted [...] expiratory volume in one second decline increased by -3.8 ml/yr (-6.3 to -2.9) in transitional women and -5.2 ml/yr (-8.3 to -2.0) in postmenopausal women. CONCLUSIONS: Lung function declined more rapidly among
Father's environment before conception and asthma risk in his children: a multi-generation analysis of the Respiratory Health In Northern Europe... (Publications)
clustering by family. RESULTS: Non-allergic early-onset asthma (asthma without hay fever, present in 5.8%) was more common in the offspring with fathers who smoked before conception {odds ratio [OR] = 1 [...] highest if father started smoking before age 15 years [3.24 (1.67-6.27)], even if he stopped more than 5 years before conception [2.68 (1.17-6.13)]. Fathers' pre-conception welding was independently associated
Efficacy and pharmacokinetics of OZ78 and MT04 against a natural infection with <em>Fasciola hepatica</em> in sheep (Publications)
samples were collected at 0 and 6h post-administration. Plasma mean peak concentration was 11.1µg/ml at 1.5h for OZ78 and 4.8µg/ml at 4.2h for MT04. Mean AUC of OZ78 and MT04 was 6698 and 3567µgmin/ml, respectively [...] burden and adult worm counts in vivo, whereas MT04 displayed a significant egg count reduction of 98.5% and a worm burden reduction of 92%. In conclusion, our study reveals an excellent activity of MT04
Community-based surveillance to monitor mortality in a malaria-endemic and Ebola-epidemic setting in rural Guinea (Publications)
table proportional mortality decreased by 26.5% (95% confidence interval [CI] = 13.9-33.1, P < 0.001) in the program area and by 6.6% (95% CI = -17.3-30.5, P = 0.589) in Koundou. Sixty-eight deaths were