The candidate blood-stage malaria vaccine P27A induces a robust humoral response in a fast track to the field phase I trial in exposed and non exposed... (Publications)
Switzerland and in Tanzania. P27A antigen (10 or 50mug), adjuvanted with Alhydrogel(R) or GLA-SE (2.5 or 5mug), or control rabies vaccine (Verorab(R)) were administered intramuscularly to 16 malaria non-exposed
Estimating the seroincidence of scrub typhus using antibody dynamics after infection (Publications)
1.8 for 23.6 months for IgG and an OD of 1 for 4.5 months for IgM. Among 18- to 29-year-olds, the seroincidence was 10 per 1,000 person-years (95% CI, 5-19) in Tamil Nadu, India, and 14 per 1,000 person-years
Wounds to the dorsal carpus (coronation injury) in horses: treatment, complications and survival (Publications)
prognosis for hospital survival was 97.8% and the long-term coronation specific mortality risk was 4.3%. 87.5% were sound and returned to intended use. Risk factors for prolonged hospitalisation time were extensor [...] tendon involvement (4.2 days), carpal joint involvement (3.8 days) and complications (skin necrosis [9.5 days] and local infection [3.2 days]. Coronation injuries reccurred in 8.8% and 20% had evidence of
Oral fexinidazole for late-stage African <em>Trypanosoma brucei gambiense </em>trypanosomiasis: a pivotal multicentre, randomised, non-inferiority... (Publications)
Therefore, we aimed to assess the safety and efficacy of an oral regimen of fexinidazole (a 2-substituted 5-nitroimidazole with proven trypanocidal activity) versus nifurtimox eflornithine combination therapy [...] statisticians were masked to treatment. Oral fexinidazole was given once a day (days 1-4: 1800 mg, days 5-10: 1200 mg). Oral nifurtimox was given three times a day (days 1-10: 15 mg/kg per day) with eflornithine
Associations between metal constituents of ambient particulate matter and mortality in England: an ecological study (Publications)
sales and ethnicity, we found associations between cardiovascular mortality and PM2.5 copper with interdecile range (IDR 2.6-5.7 ng/m(3)) and IDR relative risk (RR) 1.005 (95%CI 1.001 to 1.009) and between
Asymptomatic <em>Plasmodium</em> infection and glycemic control in adults: results from a population-based survey in south-central Côte d'Ivoire (Publications)
positivity for FG and HbA1c independent of diabetes risk factors. RESULTS: Prevalence of PI was 10.1% (5.5% microscopy; 9.7% RDT) without clinical fever. Prevalence of FG-based prediabetes (45.8%) and diabetes
Boosting effect of IL-7 in interferon gamma release assays to diagnose <em>Mycobacterium tuberculosis</em> infection (Publications)
higher release of IFN-gamma in individuals with active TB from 4.2IU/ml (IQR 1.4-6.9IU/ml) to 5.1IU/ml (IQR 1.5-8.1IU/ml, p = 0.0057), and we found an indication of a lower release of both IFN-gamma and IP-10
Incidence trends of airflow obstruction among European adults without asthma: a 20-year cohort study (Publications)
ator AO (AOpost-BD), which is the primary characteristic of COPD. AO incidence was 4.4 (95% CI: 3.5-5.3) male and 3.8 (3.1-4.6) female cases/1,000/year. Among ever smokers (median pack-years: 20, males;
Human African trypanosomiasis (Publications)
very advanced cases. The treatment-related mortality rate consequently dropped from 5% with melarsoprol to around 0.5%. A single-dose oral treatment, acoziborole, has completed Phase III trials and may
HPLC-based activity profiling for antiplasmodial compounds in the traditional Indonesian medicinal plant <em>Carica papaya</em> L (Publications)
HPLC-MS and MPLC-ELSD. Structures were established by HR-ESI-MS and NMR spectroscopy. For compounds 5 and 7 absolute configuration was confirmed by comparison of experimental and calculated electronic circular [...] nicotiflorin. Five compounds isolated from the alkaloidal fraction were piperidine alkaloids. Compounds 5 and 6 were inactive carpamic acid and methyl carpamate, while three alkaloids 7-9 showed high antiplasmodial
