Effectiveness and profitability of preventive veterinary interventions in controlling infectious diseases of ruminant livestock in sub-Saharan Africa:... (Publications)
livestock diseases. The effectiveness and/or profitability of antimicrobial treatment (n = 5), test and slaughter (n = 5), and use of lay animal health workers (n = 1) applied exclusively, were evaluated in
Antitrypanosomal and antileishmanial activities of flavonoids and their analogues: in vitro, in vivo, structure-activity relationship, and... (Publications)
avone (IC50s, 0.5 microg/ml) and catechol (IC50, 0.8 microg/ml). The activity against T. cruzi was moderate, and only chrysin dimethylether and 3-hydroxydaidzein had IC50s less than 5.0 microg/ml. The
Efficacy and cost-effectiveness of environmental management for malaria control (Publications)
tuning of the environmental management strategies to achieve a high level of performance. Within 3-5 years, malaria-related mortality, morbidity and incidence rates were reduced by 70-95%. Over the entire [...] costs per death and malaria attack averted were US$ 858 and US$ 22.20, respectively. Over the initial 3-5 years start-up period, analogous to the short-duration of cost-effectiveness analyses of current studies
Community-based surveillance to monitor mortality in a malaria-endemic and Ebola-epidemic setting in rural Guinea (Publications)
table proportional mortality decreased by 26.5% (95% confidence interval [CI] = 13.9-33.1, P < 0.001) in the program area and by 6.6% (95% CI = -17.3-30.5, P = 0.589) in Koundou. Sixty-eight deaths were
Prevalence of asthma-like symptoms with ageing (Publications)
the prevalence of 'wheeze' and 'wheeze in the absence of a cold' decreased (-2.4%, 95% CI -3.5 to -1.3%; -1.5%, 95% CI -2.4 to -0.6%, respectively) but the prevalence of asthma attacks, use of asthma medication
Oral fexinidazole for late-stage African <em>Trypanosoma brucei gambiense </em>trypanosomiasis: a pivotal multicentre, randomised, non-inferiority... (Publications)
Therefore, we aimed to assess the safety and efficacy of an oral regimen of fexinidazole (a 2-substituted 5-nitroimidazole with proven trypanocidal activity) versus nifurtimox eflornithine combination therapy [...] statisticians were masked to treatment. Oral fexinidazole was given once a day (days 1-4: 1800 mg, days 5-10: 1200 mg). Oral nifurtimox was given three times a day (days 1-10: 15 mg/kg per day) with eflornithine
DNA methylation in newborns and maternal smoking in pregnancy: genome-wide consortium meta-analysis (Publications)
methylated in relation to maternal smoking at genome-wide statistical significance (false discovery rate, 5%), including 2,965 CpGs corresponding to 2,017 genes not previously related to smoking and methylation [...] expression. We observed enrichment in pathways and processes critical to development. In older children (5 cohorts, n = 3,187), 100% of CpGs gave at least nominal levels of significance, far more than expected
Boosting effect of IL-7 in interferon gamma release assays to diagnose <em>Mycobacterium tuberculosis</em> infection (Publications)
higher release of IFN-gamma in individuals with active TB from 4.2IU/ml (IQR 1.4-6.9IU/ml) to 5.1IU/ml (IQR 1.5-8.1IU/ml, p = 0.0057), and we found an indication of a lower release of both IFN-gamma and IP-10
The candidate blood-stage malaria vaccine P27A induces a robust humoral response in a fast track to the field phase I trial in exposed and non exposed... (Publications)
Switzerland and in Tanzania. P27A antigen (10 or 50mug), adjuvanted with Alhydrogel(R) or GLA-SE (2.5 or 5mug), or control rabies vaccine (Verorab(R)) were administered intramuscularly to 16 malaria non-exposed
Efficacy and pharmacokinetics of OZ78 and MT04 against a natural infection with <em>Fasciola hepatica</em> in sheep (Publications)
samples were collected at 0 and 6h post-administration. Plasma mean peak concentration was 11.1µg/ml at 1.5h for OZ78 and 4.8µg/ml at 4.2h for MT04. Mean AUC of OZ78 and MT04 was 6698 and 3567µgmin/ml, respectively [...] burden and adult worm counts in vivo, whereas MT04 displayed a significant egg count reduction of 98.5% and a worm burden reduction of 92%. In conclusion, our study reveals an excellent activity of MT04