Antibiotic-resistant <em>Escherichia coli</em> in drinking water samples from rural Andean households in Cajamarca, Peru (Publications)
isolated in 37.3% (n = 117), Klebsiella spp. in 8.0% (n = 25), Enterobacter spp. in 5.1% (n = 16), and Citrobacter spp. in 2.5% (n = 8). Of the 117 E. coli samples, 48.7% (95% CI [39.4, 58.1], n = 57) showed
Safety and protective efficacy of PfSPZ vaccine administered to HIV negative and positive Tanzanian adults (Publications)
HIV+ Tanzanians (HIV viral load < 40 copies/mL, CD4 counts > 500 cells/µL). Participants received 5 doses of PfSPZ Vaccine or normal saline over 28 days followed by controlled human malaria infection [...] adverse events in the 9 HIV- and 12 HIV+ participants. After CHMI, 6/6 normal saline (NS) controls, 1/5 HIV- vaccinees and 4/4 HIV+ vaccinees were Pf positive by qPCR. Post-immunization, anti-PfCSP (isotype
Effect of ibandronate on spontaneous osteonecrosis of the knee: a randomized, double-blind, placebo-controlled trial (Publications)
+/- 10.7 years) with ON of the knee were assigned to receive either ibandronate (cumulative dose, 13.5 mg) or placebo intravenously (divided into five doses 12 weeks). All subjects received additional treatment [...] reduced in both ibandronate- (mean change, -2.98; 95 % CI, -4.34 to -1.62) and placebo- (-3.59; 95 % CI, -5.07 to -2.12) treated subjects (between-group comparison adjusted for age, sex, and osteonecrosis type
Reduced exposure to PM10 and attenuated age-related decline in lung function (Publications)
individual home outdoor PM10 declined over the 11-year follow-up period (median, -5.3 mug per cubic meter; interquartile range, -7.5 to -4.2). In mixed-model regression analyses, with adjustment for confounders
The relevance of commuter and work/school exposure in an epidemiological study on traffic-related air pollution (Publications)
concentrations. Mean contribution of commuting to total weekly exposure was small (3.2%; range 0.1-13.5%). Thus, ignoring commute in the total population may not significantly underestimate health effects [...] Basel-Country, ignoring commute may produce, however, a significant attenuation bias of 4% (95% CI: 4-5%). Our results illustrate the importance of including work/school locations in assessments of long-term
Transient hyperglycemia in patients with tuberculosis in Tanzania: implications for diabetes screening algorithms (Publications)
DM prevalence was significantly higher among TB patients (N=539; FCG> 7mmol/L:4.5%, 2-hCG> 11mmol/L:6.8% and HbA1c> 6.5%:9.3%) compared to controls (N=496; 1.2%, 3.1% and 2.2%). Association between hy
Modifying effect of a common polymorphism in the interleukin-6 promoter on the relationship between long-term exposure to traffic-related particulate... (Publications)
(SDNN) (GG-carriers: -1.8%; 95% confidence interval -3.5 to 0.01; pinteraction(additive) = 0.028); and low frequency power (LF) (GG-carriers: -5.7%; 95%CI: -10.4 to -0.8; pinteraction(dominant) = 0.049)
Genome-wide association study of lung function decline in adults with and without asthma (Publications)
Community Respiratory Health Survey). The associations of FEV(1) and FEV(1)/FVC ratio decrease with 2.5 million single nucleotide polymorphisms (SNPs) were estimated. Thirty loci were followed up by in silico [...] ranking signal, TUSC3, which is associated with FEV(1)/FVC ratio decrease in asthmatic participants (P = 5.3 x 10(-8)), did not replicate. SNPs previously associated with cross-sectional lung function were not
Common SIRT1 variants modify the effect of abdominal adipose tissue on aging-related lung function decline (Publications)
FEV1/FVC decline was accelerated up to -0.5 % (95 % CI -1.0 to 0 %) and -0.7 % (-1.3 to -0.2 %) over interquartile range increases in BMI (2.4 kg/m(2)) or weight (6.5 kg), respectively. For FEF25-75 decline
Travel-related health risks in moderately and severely immunocompromised patients: a case-control study (Publications)
7%) [OR = 4.8 , 95% CI 1.01-22.70; P = 0.048]. Most cases were related to infectious diseases (5/9, 55.5%), others were pulmonary embolism (2/9, 22%), inflammatory disease and trauma (1/9, 11.1% each)