Health system readiness and the implementation of rectal artesunate for severe malaria in sub-Saharan Africa: an analysis of real-world costs and... (Publications)
We calculated the equivalent annual cost of rectal artesunate implementation per child younger than 5 years at risk of severe malaria, from a health system perspective, separating neglected routine health [...] ng the neglected, routine health system components accounted for the majority of these costs at 71.5%, 65.4%, and 76.4% of per-child costs, respectively. Incremental rectal artesunate costs accounted for
Cervical cancer screening cascade for women living with HIV: a cohort study from Zimbabwe (Publications)
85.4% (95% CI 83.5–87.1) at two years. Among the 396 WLHIV who received screen-positive tests in the study, the cumulative incidence of treatment after a positive screening test was 79.5% (95% CI 75.1–83
Efficacy and safety of moxidectin-albendazole and ivermectin-albendazole combination therapy compared to albendazole monotherapy in adolescents and... (Publications)
s with primary outcome data, we observed CRs of 15.3% (11/72) in the moxidectin-albendazole and 22.5% (16/71) in the ivermectin-albendazole arm, which did not differ significantly from the CR of 13.4% [...] adverse events were abdominal pain (range across arms: 11.9-20.9%), headache (4.7-14.3%), and itching (5.8-13.1%), which were predominantly mild and transient. CONCLUSIONS: All therapies showed similar low
Doxycycline responding illnesses in returning travellers with undifferentiated non-malaria fever: a European multicenter prospective cohort study (Publications)
travellers with undifferentiated NMF. RESULTS: Among 347 travellers with undifferentiated NMF, 106 (30.5%) were finally diagnosed with DRI. Only 57 (53.8%) of the 106 DRI infections were diagnosed by the standard [...] Rickettsia spp., 16 (15.1%) C. burnetii; 15 (14.2%) Bartonella spp.; 13 (12.3%) Leptospira spp.; and 10 (9.5%) A. phagocytophilum. The only predictive factor associated with DRI was presenting an eschar (aOR 39
Ultrasonographic findings in patients with abdominal symptoms or trauma presenting to an emergency room in rural Tanzania (Publications)
females (54.2%) and abdominal free fluid in 368 (32.6%) patients; no abnormality was found in 150 (13.5%) patients. A tumour in the abdomen or pelvis was found in 183 (16.2%) patients, an intrauterine pregnancy [...] received an eFAST, and 53 (18.7%) had positive findings. A total of 27 (9.4%) trauma patients and 51 (4.5%) non-trauma patients were sent directly to the operating theatre. CONCLUSION: In this study, ultrasound
Predicting complicated appendicitis based on clinical findings: the role of Alvarado and appendicitis inflammatory response scores (Publications)
inflammation. The complicated appendicitis cohort had a mean Alvarado score of 7.03 and a mean AIR of 5.21. This compared to a mean Alvarado of 6.53 and a mean AIR of 4.07 for the uncomplicated appendicitis [...] The highest Alvarado score with a sensitivity of > 90% to detect complicated appendicitis was > == 5 (sensitivity = 95%, specificity 8.99%). The highest AIR score with a sensitivity of > 90% to detect
Inhibiting activities of the secondary metabolites of <em>Phlomis brunneogaleata</em> against parasitic protozoa and plasmodial enoyl-ACP reductase, a... (Publications)
D-glucopyranoside and three caffeic acid esters, chlorogenic acid, 3-O-caffeoylquinic acid methyl ester and 5- O-caffeoylshikimic acid were isolated. The structures of the pure compounds were elucidated by means [...] determined to be the major anti-malarial principles of the crude extract (IC (50) values of 2.4 and 5.9 micrograms/mL, respectively). They also exhibited significant leishmanicidal activity (IC (50) = 1
Rule-based models of the interplay between genetic and environmental factors in childhood allergy (Publications)
genotype combinations gave odds ratios for current asthma of 2.1 (95% CI 1.2-3.6) and 3.2 (95% CI 2.0-5.0) in the BAMSE and PARSIFAL children, respectively. Several combinations of environmental factors appeared [...] use of baby formula and antibiotics early in life was associated with an odds ratio of 7.4 (95% CI 4.5-12.0) of developing asthma. Furthermore, genetic variants together with environmental factors seemed
Countdown to 2015: tracking donor assistance to maternal, newborn, and child health (Publications)
mortality and ODA per head, although at any given rate of mortality for children aged younger than 5 years or maternal mortality, there is significant variation in the amount of ODA per person received [...] If commitments are to be honoured, global aid flows will need to increase sharply during the next 5 years. The challenge will be to ensure a sufficient share of these new funds is channelled effectively
Tribendimidine and albendazole for treating soil-transmitted helminths, <em>Strongyloides stercoralis</em> and <em>Taenia</em> spp.: open-label... (Publications)
efficacy of a single oral dose of albendazole or tribendimidine (both drugs administered at 200 mg for 5- to 14-year-old children, and 400 mg for individuals > /=15 years) against soil-transmitted helminths [...] tribendimidine, the prevalence of S. stercoralis was reduced from 19.3% to 8.8% (observed cure rate 54.5%, p = 0.107), and that of Taenia spp. from 26.3% to 8.8% (observed cure rate 66.7%, p = 0.014). Similar