Determining treatment needs at different spatial scales using geostatistical model-based risk estimates of schistosomiasis (Publications)
population if country-level schistosomiasis prevalence estimates are considered, and 81.5 million treatments (50% CI: 67.3-107.5 million) if estimation is based on a more refined spatial scale at the provincial
Dynamics of <em>Schistosoma haematobium</em> egg output and associated infection parameters following treatment with praziquantel in school-aged... (Publications)
of infection-associated parameters decreased after treatment, reaching a minimum of 2.4% in weeks 5 (proteinuria) and 7 (leukocyturia) post-treatment, and 16.3% at the end of week 8 (microhaematuria) [...] additional tool for evaluating treatment outcomes in areas with high endemicity, preferably at weeks 5 and 6 post-treatment. The delayed decrease of microhaematuria confirms that lesions in the urinary tract
Comparative genomics of the anopheline glutathione s-transferase epsilon cluster (Publications)
analysis and protein modelling gave evidence for positive selection on codons of the catalytic site in GSTE5 albeit its origin seems to predate the introduction of chemical insecticides. Gene expression profiles [...] World Cellia subgenus, instead of a secondary loss. The modifications of the catalytic site within GSTE5 may represent adaptations to new habitats
Health services for Buruli ulcer control: lessons from a field study in Ghana (Publications)
introduced in the course of the programme, was highest in the last year (35.4% in the first, 23.5% in the second and 42.5% in the third year). Early antibiotic treatment prevented recurrences which was consistent
Quinolone amides as anti-trypanosomal lead compounds with in vivo activity (Publications)
synthesized compounds GHQ242 and GHQ243 were characterized by an elimination half-life ranging from 1.5 to 3.5 hours after i.p. administration (4 mice/compound), moderate to strong human serum albumin binding
Genetic diversity and protective efficacy of the RTS,S/AS01 malaria vaccine (Publications)
group of 4577 RTS,S/AS01-vaccinated participants and 2335 control-vaccinated participants who were 5 to 17 months of age, the 1-year cumulative vaccine efficacy was 50.3% (95% confidence interval [CI] [...] differential allele-specific vaccine efficacy. Conclusions These results suggest that among children 5 to 17 months of age, the RTS,S vaccine has greater activity against malaria parasites with the matched
Respiratory health in cleaners in northern Europe: is susceptibility established in early life? (Publications)
RESULTS: Among 2138 ever-cleaners the risks of wheeze (OR 1.4, 95% CI 1.3-1.6), adult-onset asthma (1.5 [1.2-1.8]) and self-reported COPD (1.7 [1.3-2.2]) were increased. The risk increased with years in [...] years was significantly stronger for those with early life disadvantage than in those without (1.8 [1.5-2.3] vs. 1.3 [0.96-1.8]; pinteraction 0.035). CONCLUSIONS: Occupational cleaners had increased risk
Spatial and socio-demographic determinants of contraceptive use in the upper east region of Ghana (Publications)
selected covariates on contraceptive use. All tests were deemed to be statistically significant at 5% level statistical significance. RESULTS: Results show that contraceptive use is generally low (about [...] uptake of modern contraceptive use, reduce unwanted pregnancies and hasten the attainment of MDG 4 & 5 in Ghana
How long can stool samples be fixed for an accurate diagnosis of soil-transmitted helminth infection using mini-FLOTAC? (Publications)
to a single Kato-Katz thick smear and Mini-FLOTAC examination; 12 aliquots of stool were fixed in 5% formalin and subsequently examined by Mini-FLOTAC up to 31 days after collection. PRINCIPAL FINDINGS: [...] that for a qualitative diagnosis of soil-transmitted helminth infection, stool samples can be fixed in 5% formalin for at least 30 days. However, for an accurate quantitative diagnosis of hookworm, we suggest
Distribution and risk factors for <em>Plasmodium</em> and helminth co-infections: a cross-sectional survey among children in Bagamoyo district,... (Publications)
992 children analyzed, the prevalence of Plasmodium infection was 13% (130/992), helminth 28.5% (283/992); 5% (50/992) had co-infection with Plasmodium and helminth. The prevalence rate of Plasmodium, specific