Quinolone amides as anti-trypanosomal lead compounds with in vivo activity (Publications)
synthesized compounds GHQ242 and GHQ243 were characterized by an elimination half-life ranging from 1.5 to 3.5 hours after i.p. administration (4 mice/compound), moderate to strong human serum albumin binding
Genetic diversity and protective efficacy of the RTS,S/AS01 malaria vaccine (Publications)
group of 4577 RTS,S/AS01-vaccinated participants and 2335 control-vaccinated participants who were 5 to 17 months of age, the 1-year cumulative vaccine efficacy was 50.3% (95% confidence interval [CI] [...] differential allele-specific vaccine efficacy. Conclusions These results suggest that among children 5 to 17 months of age, the RTS,S vaccine has greater activity against malaria parasites with the matched
Health services for Buruli ulcer control: lessons from a field study in Ghana (Publications)
introduced in the course of the programme, was highest in the last year (35.4% in the first, 23.5% in the second and 42.5% in the third year). Early antibiotic treatment prevented recurrences which was consistent
Comparative genomics of the anopheline glutathione s-transferase epsilon cluster (Publications)
analysis and protein modelling gave evidence for positive selection on codons of the catalytic site in GSTE5 albeit its origin seems to predate the introduction of chemical insecticides. Gene expression profiles [...] World Cellia subgenus, instead of a secondary loss. The modifications of the catalytic site within GSTE5 may represent adaptations to new habitats
Inhibiting activities of the secondary metabolites of <em>Phlomis brunneogaleata</em> against parasitic protozoa and plasmodial enoyl-ACP reductase, a... (Publications)
D-glucopyranoside and three caffeic acid esters, chlorogenic acid, 3-O-caffeoylquinic acid methyl ester and 5- O-caffeoylshikimic acid were isolated. The structures of the pure compounds were elucidated by means [...] determined to be the major anti-malarial principles of the crude extract (IC (50) values of 2.4 and 5.9 micrograms/mL, respectively). They also exhibited significant leishmanicidal activity (IC (50) = 1
Countdown to 2015: tracking donor assistance to maternal, newborn, and child health (Publications)
mortality and ODA per head, although at any given rate of mortality for children aged younger than 5 years or maternal mortality, there is significant variation in the amount of ODA per person received [...] If commitments are to be honoured, global aid flows will need to increase sharply during the next 5 years. The challenge will be to ensure a sufficient share of these new funds is channelled effectively
Genetic characterization and population structure of drug-resistant <em>Mycobacterium tuberculosis</em> isolated from Brazilian patients using... (Publications)
of 22.5%. We detected twenty novel mutations in three resistance genes, and six of these were observed in eight phenotypically resistant isolates. A cluster analysis of 170 isolates showed that 43.5% of
Estimating prevalence and infection intensity of soil-transmitted helminths using quantitative polymerase chain reaction and kato-katz in school-age... (Publications)
112 (58.6%) became positive. Similar prevalence for Ascaris lumbricoides (37.5% versus 34.6%) and Trichuris trichiura (6.5% versus 6.1%) were found by qPCR and Kato-Katz, respectively, while qPCR detected
Efficacy and safety of moxidectin-albendazole and ivermectin-albendazole combination therapy compared to albendazole monotherapy in adolescents and... (Publications)
s with primary outcome data, we observed CRs of 15.3% (11/72) in the moxidectin-albendazole and 22.5% (16/71) in the ivermectin-albendazole arm, which did not differ significantly from the CR of 13.4% [...] adverse events were abdominal pain (range across arms: 11.9-20.9%), headache (4.7-14.3%), and itching (5.8-13.1%), which were predominantly mild and transient. CONCLUSIONS: All therapies showed similar low
Cervical cancer screening cascade for women living with HIV: a cohort study from Zimbabwe (Publications)
85.4% (95% CI 83.5–87.1) at two years. Among the 396 WLHIV who received screen-positive tests in the study, the cumulative incidence of treatment after a positive screening test was 79.5% (95% CI 75.1–83