The trypanocidal benzoxaborole AN7973 inhibits trypanosome mRNA processing (Publications)
for veterinary trypanosomosis. In all kinetoplastids, transcription is polycistronic. Individual mRNA 5'-ends are created by trans splicing of a short leader sequence, with coupled polyadenylation of the [...] not, however, always correlate and prolonged selection of trypanosomes in AN7973 resulted in only 1.5-fold resistance. It is therefore possible that the modes of action of oxaboroles that target trypanosome
Effects of hydroxyethyl starch 130/0.4 on serum creatinine concentration and development of acute kidney injury in nonazotemic cats (Publications)
cohort received a mean volume of 98.5 +/- 76.2 mL/kg (range, 8-278 mL/kg) HES over a median of 4 (range, 1-11) days, resulting in a median dose of 20.1 (range, 8-40.5) mL/kg per day. Short-term %change
Efficacy and safety of ascending dosages of tribendimidine against hookworm infections in children: a randomized controlled trial (Publications)
dose. The ERRs (geometric mean) were 30.6% (95% CI, -24.7-64.1, 65.4% (95% CI, 24.5-85.9), 82.1% (95% CI, 58.4-92.5) and 92.2% (95% CI, 81.0-97.1) for placebo, 100 mg, 200 mg and 400 mg tribendimidine
Nationwide school malaria parasitaemia survey in public primary schools, the United Republic of Tanzania (Publications)
from 0 to 76.4% among councils. The malaria prevalence was below 5% in 62 of the 166 councils and above 50% in 18 councils and between 5 and 50% in the other councils. The variation of malaria prevalence
Estimating prevalence and infection intensity of soil-transmitted helminths using quantitative polymerase chain reaction and Kato-Katz in school-age... (Publications)
112 (58.6%) became positive. Similar prevalence for Ascaris lumbricoides (37.5% versus 34.6%) and Trichuris trichiura (6.5% versus 6.1%) were found by qPCR and Kato-Katz, respectively, while qPCR detected
Genetic characterization and population structure of drug-resistant <em>Mycobacterium tuberculosis</em> isolated from Brazilian patients using... (Publications)
of 22.5%. We detected twenty novel mutations in three resistance genes, and six of these were observed in eight phenotypically resistant isolates. A cluster analysis of 170 isolates showed that 43.5% of
Predicting complicated appendicitis based on clinical findings: the role of Alvarado and appendicitis inflammatory response scores (Publications)
inflammation. The complicated appendicitis cohort had a mean Alvarado score of 7.03 and a mean AIR of 5.21. This compared to a mean Alvarado of 6.53 and a mean AIR of 4.07 for the uncomplicated appendicitis [...] The highest Alvarado score with a sensitivity of > 90% to detect complicated appendicitis was > == 5 (sensitivity = 95%, specificity 8.99%). The highest AIR score with a sensitivity of > 90% to detect
Ultrasonographic findings in patients with abdominal symptoms or trauma presenting to an emergency room in rural Tanzania (Publications)
females (54.2%) and abdominal free fluid in 368 (32.6%) patients; no abnormality was found in 150 (13.5%) patients. A tumour in the abdomen or pelvis was found in 183 (16.2%) patients, an intrauterine pregnancy [...] received an eFAST, and 53 (18.7%) had positive findings. A total of 27 (9.4%) trauma patients and 51 (4.5%) non-trauma patients were sent directly to the operating theatre. CONCLUSION: In this study, ultrasound
Cervical cancer screening cascade for women living with HIV: a cohort study from Zimbabwe (Publications)
85.4% (95% CI 83.5–87.1) at two years. Among the 396 WLHIV who received screen-positive tests in the study, the cumulative incidence of treatment after a positive screening test was 79.5% (95% CI 75.1–83
Antitrypanosomal triterpenoid with an epsilon-lactone E-ring from <em>Salvia urmiensis</em> (Publications)
epsilon-lactone E-ring. The compound showed in vitro antitrypanosoal activity with an IC50 value of 5.6 muM against the Trypanosoma brucei rhodesiense STIB 900 strain and a selectivity index of 33. A possible