2,4-diaminopyrimidines as inhibitors of leishmanial and trypanosomal dihydrofolate reductase (Publications)
This paper describes the synthesis of 4'-substituted and 3',4'-disubstituted 5-benzyl-2,4-diaminopyrimidines as selective inhibitors of leishmanial and trypanosomal dihydrofolate reductase. Compounds were
Effect of offering same-day ART vs usual health facility referral during home-based HIV testing on linkage to care and viral suppression among adults... (Publications)
to be offered same-day home-based ART initiation (n = 138) and subsequent follow-up intervals of 1.5, 3, 6, 9, and 12 months after treatment initiation at the health facility or to receive usual care (n [...] care group). In the same-day group, 134 (97.8%) indicated readiness to start ART that day and 2 (1.5%) within the next few days and were given a 1-month supply of ART. At 3 months, 68.6% (94) in same-day [...] group achieved viral suppression (absolute difference, 16.0%; 4.4%-27.2%; P =...
Effectiveness of a home-based counselling strategy on neonatal care and survival: a cluster-randomised trial in six districts of rural southern... (Publications)
88% of 1,799, OR 1.5, 95% CI 1.0-2.3, p = 0.033). Facility delivery improved dramatically in both groups from 41% of 22,243 in 2007 and was 82% of 7,820 versus 75% of 7,553 (OR 1.5, 95% CI 1.2-2.0, p = [...] volunteer visit during pregnancy and postpartum, respectively. Neonatal mortality reduced from 35.0 to 30.5 deaths per 1,000 live births between 2007 and 2013 in the five districts, respectively. There was no
Efficacy, safety, and palatability of arpraziquantel (L-praziquantel) orodispersible tablets in children aged 3 months to 6 years infected with... (Publications)
age was 5.1 years (IQR 4.1-6.0) and 132 (47%) of 280 participants were female and 148 (53%) were male. Cure rates with arpraziquantel were similar to those with praziquantel (87.8% [95% CI 79.6-93.5] in cohort [...] study was conducted at two hospitals in Cote d'Ivoire and Kenya. Children with a minimum bodyweight of 5 kg in those aged 3 months to 2 years and 8 kg in those aged 2-6 years were eligible. In cohort 1, p
Luftqualität (Page)
https://www.swisstph.ch/en/projects/ludok/aktuelle-berichte/luftqualitaet
Grenzwerte überschritten, auf der Alpensüdseite teilweise auch diejenigen für lungengängigen Feinstaub (PM2.5). An allen NABEL-Stationen wurden die Grenzwerte für die weiteren Luftschadstoffe eingehalten. Die [...] Verkehr, Satellitendaten, chemischen Tranpsortmodellen und Meteorologie die Belastung mit Feinstaub PM2.5 im Jahr 2019 in einer hohen Auflösung (25x25 Meter) berechnet und für sogenannte local administrative [...] beleuchtet die Bedeutung für die Gesundheit und die Umwelt. Die...
Efficacy, safety, and palatability of arpraziquantel (L-praziquantel) orodispersible tablets in children aged 3 months to 6 years infected with... (Publications)
age was 5.1 years (IQR 4.1-6.0) and 132 (47%) of 280 participants were female and 148 (53%) were male. Cure rates with arpraziquantel were similar to those with praziquantel (87.8% [95% CI 79.6-93.5] in cohort [...] study was conducted at two hospitals in Cote d'Ivoire and Kenya. Children with a minimum bodyweight of 5 kg in those aged 3 months to 2 years and 8 kg in those aged 2-6 years were eligible. In cohort 1, p
Assessing the ecological patterns of <em>Aedes aegypti</em> in areas with high arboviral risks in the large city of Abidjan, Côte d'Ivoire (Publications)
and water storage containers. CI, HI, and BI in Anono (22.4%, 33.5% and 89.5), Ayakro (23.1%, 43.8% and 91.0), Entente (15.9%, 24.8% and 48.5) and Gbagba (23.3%, 43.0% and 102.0) were high in the respective
Effectiveness of a home-based counselling strategy on neonatal care and survival: a cluster-randomised trial in six districts of rural southern... (Publications)
88% of 1,799, OR 1.5, 95% CI 1.0-2.3, p = 0.033). Facility delivery improved dramatically in both groups from 41% of 22,243 in 2007 and was 82% of 7,820 versus 75% of 7,553 (OR 1.5, 95% CI 1.2-2.0, p = [...] volunteer visit during pregnancy and postpartum, respectively. Neonatal mortality reduced from 35.0 to 30.5 deaths per 1,000 live births between 2007 and 2013 in the five districts, respectively. There was no
Effect of offering same-day ART vs usual health facility referral during home-based HIV testing on linkage to care and viral suppression among adults... (Publications)
to be offered same-day home-based ART initiation (n = 138) and subsequent follow-up intervals of 1.5, 3, 6, 9, and 12 months after treatment initiation at the health facility or to receive usual care (n [...] care group). In the same-day group, 134 (97.8%) indicated readiness to start ART that day and 2 (1.5%) within the next few days and were given a 1-month supply of ART. At 3 months, 68.6% (94) in same-day [...] group achieved viral suppression (absolute difference, 16.0%; 4.4%-27.2%; P =...
Spectrum and prevalence of genetic predisposition in medulloblastoma: a retrospective genetic study and prospective validation in a clinical trial... (Publications)
deficiency. In patients with a genetic predisposition to medulloblastoma, 5-year progression-free survival was 52% (95% CI 40-69) and 5-year overall survival was 65% (95% CI 52-81); these survival estimates [...] used to further classify medulloblastoma genomes into two groups, a clock-like group (signatures 1 and 5) and a homologous recombination repair deficiency-like group (signatures 3 and 8), and chromothripsis [...] These estimates were replicated in the prospective clinical cohort...