Efficacy of RTS,S/AS01E vaccine against malaria in children 5 to 17 months of age (Publications)
than 2500 parasites per microliter, and the mean duration of follow-up was 7.9 months (range, 4.5 to 10.5). RESULTS: A total of 894 children were randomly assigned to receive the RTS,S/AS01E vaccine or [...] We evaluated the efficacy of RTS,S given with a more immunogenic adjuvant system (AS01E) in children 5 to 17 months of age, a target population for vaccine licensure. METHODS: We conducted a double-blind
Studies on <em>Dipetalonema viteae</em> (Filarioidea). 5. Ultrastructural aspects of the antibody-dependent cell-mediated destruction of microfilariae (Publications)
The antibody-dependent cell-mediated destruction of Dipetalonema viteae microfilariae was followed by electron microscopy both in vitro and within micropore chambers in vivo. There was a correlation b
Oxidative properties of ambient PM2.5 and elemental composition: Heterogeneous associations in 19 European cities (Publications)
extent to which constituents of PM2.5 (transition metals, sodium, chloride) contribute to the ability to generate hydroxyl radicals ((OH)-O-center dot) in vitro in PM2.5 sampled at 20 locations in 19 European [...] European centres participating in the European Community Respiratory Health Survey. PM2.5 samples (n = 716) were collected on filters over one year and the oxidative activity of particle suspensions obtained
Solid phase synthesis and antiprotozoal evaluation of di- and trisubstituted 5'-carboxamidoadenosine analogues (Publications)
with promising activity: N(6)-benzyl-5'-N-phenylcarboxamidoadenosine with an IC(50) value of 0.91muM against Trypanosoma brucei rhodesiense and N(6)-diphenylethyl-5'-phenylcarboxamidoadenosine with an IC(50) [...] speed up the process of lead finding and we pursued the solid-phase synthesis of di- and trisubstituted 5'-carboxamidoadenosine derivatives by using a safety-catch approach. While efforts with Kenner's sulfonamide
Acute-phase proteins and mortality in status epilepticus: a 5-year observational cohort study (Publications)
OBJECTIVE: Acute-phase proteins, such as C-reactive protein and albumin, may be related with course and outcome in status epilepticus, as changes of cytokine levels and blood-brain barrier breakdown d
Antiprotozoal activity of dicationic 3,5-diphenylisoxazoles, there prodrugs and aza-analogues (Publications)
Fifty novel prodrugs and aza-analogues of 3,5-bis(4-amidinophenyl)isoxazole and its derivatives were prepared. Eighteen of the 24 aza-analogues exhibited IC50 values below 25nM against Trypanosoma brucei [...] for efficacy in mice infected with T. b. rhodesiense STIB900. Six diamidines cured 4/4 mice at daily 5mg/kg intraperitoneal doses for 4days, giving results far superior to pentamidine and furamidine. One
Culture and psychiatric evaluation: operationalizing cultural formulation for DSM-5 (Publications)
guidance on implementation, training, and application in diverse settings. To address this need, DSM-5 introduced a cultural formulation interview (CFI) that operationalizes the process of data collection [...] article summarizes the literature reviews and analyses of experience with the OCF conducted by the DSM-5 Cross-Cultural Issues Subgroup (DCCIS) that informed the development of the CFI. We review the history