Prevalence and predictors of <em>Aspergillus</em> seropositivity and chronic pulmonary aspergillosis in an urban tertiary hospital in Sierra Leone: a... (Publications)
(17.3%) with past TB. Common radiologic abnormalities reported were localized fibrotic changes 62 (31.5%), consolidation 54 (27.4%), infiltrates 46 (23.4%), hilar adenopathy 40 (20.3%) and pleural effusion [...] effusion 35 (17.85) and thickening 23 (11.7%). Common symptoms were weight loss 144 (73.1%), cough 135 (68.5%), fever 117 (59.4%) and dyspnea 90 (45.7%). Current or past TB infection {aOR 3.52, 95% CI (1.46, 8
Excess mortality during the warm summer of 2015 in Switzerland (Publications)
episodes identified in summer 2015 by use of seven different definitions. RESULTS: 804 excess deaths (5.4%, 95% confidence interval [CI] 3.07.9%) were estimated for summer 2015 compared with previous summers [...] occurred in people aged 75 years and older. Ticino (10.3%, 95% CI -1.822.4%), Northwestern Switzerland (9.5%, 95% CI 2.716.3%) and Espace Mittelland (8.9%, 95% CI 3.714.1%) showed highest excess mortality during
Reproducibility of retrospective assessment of outdoor time-activity patterns as an individual determinant of long-term ambient ozone exposure (Publications)
patterns were tested in 168 lifelong residents (ages 17-21) of California. A test-retest design (within 5-7 days) was employed. (1) Based on a set of questions (AQUES) on outdoor 'heavy' and 'moderate' activity [...] values differed across approaches, ranging from 1.0 (ATAB) to an unrealistically high estimate of 3.5 (A24H) h/day. The ATAB mean values were close to expectations when compared to published data. CONCLUSIONS:
Safety and efficacy of C-reactive protein-guided antibiotic use to treat acute respiratory infections in Tanzanian children: a planned subgroup... (Publications)
0.06, 0.040.09). There were fewer secondary hospitalizations and deaths in the CRP arm: 0.5% (4/865) versus 1.5% (13/854, RR 0.30, 0.100.93). Conclusions: CRP testing using a high cut-off, combined with
Seroprevalence of <em>Rickettsia</em> spp. and <em>Orientia tsutsugamushi</em> in indigenous populations from the Sierra Nevada de Santa Marta,... (Publications)
We observed an overall seroprevalence of 26.2% (95% confidence interval [CI] 22.5-30.1] for Rickettsia spp. of the SFG, 5.4% (95% CI 3.6-7.6) for Rickettsia spp. of the TG and 4.3% (95% CI 2.7-6.3) for
Malaria treatment for prevention: a modelling study of the impact of routine case management on malaria prevalence and burden (Publications)
these example settings in terms of prevalence reduction and clinical cases averted in children under 5 years old and the total population. RESULTS: The most significant prevalence reduction - up to 50% - [...] effective treatment coverage to 60% reduced the risk in high-risk areas (prevalence in children under 5 years old > 0.3), affecting 39% of young children in Benin and 20% in Mozambique previously living in
Excess mortality during COVID-19 pandemic in Bangladesh: evidence from a rural survey (Publications)
p-score and incidence rate ratio (IRR) utilising Poisson segmented regression. We employed the InterVA-5 algorithm to attribute causes of death. Proportional distribution and cause-specific mortality rates [...] stroke (CSMR = 108.0, CI = 102.6-114.0), and acute respiratory infection (CSMR = 61.0, CI = 55.1-66.5), all displaying significantly higher mortality rates than in previous years. Older age (IRR = 1.6)
Signatures of transmission in within-host <em>Mycobacterium tuberculosis </em>complex variation: a retrospective genomic epidemiology study (Publications)
across studies: mean 168·6 minority variants (95% CI 151·4-185·9) for the Colangeli et al dataset, 5·8 (1·5-10·2) for Guthrie et al (p
Respiratory and allergic outcomes among farmworkers exposed to pesticides in Costa Rica (Publications)
concentrations of 15 pesticide biomarkers measured in urine samples collected during two visits (4-5 weeks apart). We fitted "traditional" Bayesian and Bayesian Weighted Quantile Sum (BWQS) regression [...] 1.67), and rhinitis (aOR = 1.34; 95 % CrI: 1.15, 1.56). Higher urinary concentrations of boscalid-5-hydroxy (metabolite of fungicide boscalid) were associated with increased odds of asthma symptoms or
Spatiotemporal modelling of airborne birch and grass pollen concentration across Switzerland: a comparison of statistical, machine learning and... (Publications)
these six models through multiple linear regression to develop an ensemble hybrid model. RESULTS: The 5(th)-95(th) percentiles of birch and grass pollen concentrations were 0-151 and 0-105 grains/m(3), r [...] linear models (LASSO, Ridge, Elastic net) for both pollen types, with RMSE's ranging from 105.9 to 140.5 grains/m(3) for birch and from 20 to 25.4 grains/m(3) for grass pollen. The Random forest algorithm