Transportation noise impairs cardiovascular function without altering sleep: the importance of autonomic arousals (Publications)
scenarios compared to the quiet ambient scenario played back during the baseline and recovery nights (F5,117 = 10.2, p < 0.001). Nocturnal transportation noise did not significantly impact polysomnographically [...] a result related to increased cumulative duration of autonomic arousals during the noise nights (F5,106 = 3.4, p < 0.001; correlation: rpearson = 0.64, p = 0.006). Conclusion: Under controlled laboratory
Long-term exposure to ultrafine particles and natural and cause-specific mortality (Publications)
t models with the major regulated pollutants nitrogen dioxide (NO(2)) and fine particles (PM(2)(.)(5) and PM(10)), and the health relevant combustion aerosol pollutant (elemental carbon (EC)) were assessed [...] follow-up. The correlation of UFP concentration with other pollutants ranged from moderate (0.59 (PM(2)(.)(5))) to high (0.81 (NO(2))). We found a significant association between annual average UFP exposure and
Prevalence and predictors of <em>Aspergillus</em> seropositivity and chronic pulmonary aspergillosis in an urban tertiary hospital in Sierra Leone: a... (Publications)
(17.3%) with past TB. Common radiologic abnormalities reported were localized fibrotic changes 62 (31.5%), consolidation 54 (27.4%), infiltrates 46 (23.4%), hilar adenopathy 40 (20.3%) and pleural effusion [...] effusion 35 (17.85) and thickening 23 (11.7%). Common symptoms were weight loss 144 (73.1%), cough 135 (68.5%), fever 117 (59.4%) and dyspnea 90 (45.7%). Current or past TB infection {aOR 3.52, 95% CI (1.46, 8
The contribution of malaria control interventions on spatio-temporal changes of parasitaemia risk in Uganda during 2009-2014 (Publications)
few years as a result of increased funding. Data on parasitaemia prevalence among children less than 5 years old and coverage of interventions was collected during the first two Malaria Indicator Surveys [...] Parasitaemia risk was predicted over a 2 x 2 km2 grid and the number of infected children less than 5 years old was estimated. Geostatistical variable selection was applied to identify the most important
High genetic diversity in the <em>Dirofilaria repens</em> species complex revealed by mitochondrial genomes of feline microfilaria samples from... (Publications)
the closely related species Candidatus Dirofilaria hongkongensis was proposed. Previous analysis of 2.5 kb partial mitochondrial genome sequences containing the particularly variable non-coding control region [...] distance between the valid sibling species Onchocerca volvulus and Onchocerca ochengi. Sequencing of a 2.5 kb fragment containing the control region from microfilarial DNA from additional feline blood samples
Seroprevalence of <em>Rickettsia</em> spp. and <em>Orientia tsutsugamushi</em> in indigenous populations from the Sierra Nevada de Santa Marta,... (Publications)
We observed an overall seroprevalence of 26.2% (95% confidence interval [CI] 22.5-30.1] for Rickettsia spp. of the SFG, 5.4% (95% CI 3.6-7.6) for Rickettsia spp. of the TG and 4.3% (95% CI 2.7-6.3) for
Safety and efficacy of C-reactive protein-guided antibiotic use to treat acute respiratory infections in Tanzanian children: a planned subgroup... (Publications)
0.06, 0.040.09). There were fewer secondary hospitalizations and deaths in the CRP arm: 0.5% (4/865) versus 1.5% (13/854, RR 0.30, 0.100.93). Conclusions: CRP testing using a high cut-off, combined with
Signatures of transmission in within-host <em>Mycobacterium tuberculosis </em>complex variation: a retrospective genomic epidemiology study (Publications)
across studies: mean 168·6 minority variants (95% CI 151·4-185·9) for the Colangeli et al dataset, 5·8 (1·5-10·2) for Guthrie et al (p
Malaria treatment for prevention: a modelling study of the impact of routine case management on malaria prevalence and burden (Publications)
these example settings in terms of prevalence reduction and clinical cases averted in children under 5 years old and the total population. RESULTS: The most significant prevalence reduction - up to 50% - [...] effective treatment coverage to 60% reduced the risk in high-risk areas (prevalence in children under 5 years old > 0.3), affecting 39% of young children in Benin and 20% in Mozambique previously living in
Respiratory and allergic outcomes among farmworkers exposed to pesticides in Costa Rica (Publications)
concentrations of 15 pesticide biomarkers measured in urine samples collected during two visits (4-5 weeks apart). We fitted "traditional" Bayesian and Bayesian Weighted Quantile Sum (BWQS) regression [...] 1.67), and rhinitis (aOR = 1.34; 95 % CrI: 1.15, 1.56). Higher urinary concentrations of boscalid-5-hydroxy (metabolite of fungicide boscalid) were associated with increased odds of asthma symptoms or