Salidroside pretreatment alleviates PM2.5 caused lung injury via inhibition of apoptosis and pyroptosis through regulating NLRP3 inflammasome (Publications)
conditions. To uncover the possible therapy for PM(2.5) related pulmonary disease, we evaluated the protective role of Sal pre-treatment on PM(2.5) induced lung injury in mice by utilizing the survival [...] findings strongly indicated Sal as an effective precaution against PM(2.5) induced lung injury. Pre-administration of Sal before PM(2.5) treatment reduced the mortality within 120 h and alleviated inflammatory [...] PM(2.5) treatment via regulating Bax/Bcl-2/caspase-3 and...
The air and viruses we breathe: assessing the effect the PM2.5 air pollutant has on the burden of COVID-19 (Publications)
burden of respiratory viral diseases. We assessed the effect of increasing exposure to PM2.5 (particulate matter ≤ 2.5 microns in diameter) on SARS-CoV-2 susceptibility or COVID-19 severity and projected the [...] population show that if exposure affects severity, then hospital admissions are projected to increase by 5–10% for a one-unit exposure increase. However, if exposure affects susceptibility, then infections would [...] respond to changing air pollution levels. It is also important to...
Mortality and morbidity effects of long-term exposure to low-level PM2.5, BC, NO2, and O3: an analysis of European cohorts in the ELAPSE project (Publications)
= 1.11, 1.16) for an increase of 5 mug/m(3) PM2.5, 1.09 (CI = 1.07, 1.10) for an increase of 10 mug/m(3) NO2, and 1.08 (CI = 1.06, 1.10) for an increase of 0.5 x 10(-5)/m BC for natural-cause mortality [...] = 1.02, 1.09) for an increase of 5 mug/m(3) PM2.5, 1.04 (CI = 1.02, 1.07) for an increase of 10 mug/m(3) NO2, and 1.04 (CI = 1.02, 1.06) for an increase of 0.5 x 10(-5)/m BC, and 0.95 (CI = 0.93, 0.98) [...] investigate whether the associations persisted below specific concentration values....
2-(Nitroaryl)-5-substituted-1,3,4-thiadiazole derivatives with antiprotozoal activities: <em>in vitro</em> and <em>in vivo </em>study (Publications)
Nitro-containing compounds are a well-known class of anti-infective agents, especially in the field of anti-parasitic drug discovery. HAT or sleeping sickness is a neglected tropical disease caused by
Fine particle (PM2.5) measurement methodology, quality assurance procedures, and pilot results of the EXPOLIS study (Publications)
It is the first international, population-based, large-scale study, where personal exposures to PM2.5 aerosol particles (together with volatile organic compounds and carbon monoxide) are being monitored [...] assurance and quality control (QA & QC) procedures are essential for producing reliable and comparable PM2.5 data. This paper introduces the equipment, the laboratory test results, the pilot results, the standard [...] show good comparability and repeatability between personal and...
Synthesis and evaluation of antiparasitic activities of new 4-[5-(4-phenoxyphenyl)-2H-pyrazol-3-yl]morpholine derivatives (Publications)
A series of new 4-[5-(4-phenoxyphenyl)-2H-pyrazol-3-yl]morpholine derivatives, prepared by two synthetic routes, were in vitro assayed against three Trypanosoma strains, Leishmania donovani, and Plasmodium [...] different compounds with moderate activity against T. cruzi, compound 17 showed the lowest IC50 value of 9.5 microM; thus, the series seemed to act selectively toward the different Trypanosoma parasites. Eight [...] moderately active against L. donovani, with 2, 3, and 12 being the most...
Antibodies elicited by a virosomally formulated <em>Plasmodium falciparum</em> serine repeat antigen-5 derived peptide detect the processed 47kDa... (Publications)
Serine repeat antigen-5 (SERA5) is a candidate antigen for inclusion into a malaria subunit vaccine. During merozoite release and reinvasion the 120kDa SERA5 precursor protein (P120) is processed, and [...] 57-94 of SERA5 bound to both P120 and to P47. Western blotting analysis proved for the first time the presence of SERA5 P47 in sporozoites. In immunofluorescence assays, the mAbs stained SERA5 in all its [...] conjugates, incorporating amino acid sequence stretches from the N-terminus of...
