Unique modifications of translation elongation factors (Publications)
proteins carrying these modifications, elongation factor 1A, elongation factor 2 and initiation factor 5A, are all involved in elongation steps of translation. For diphthamide and, in part, hypusine, functional
<em>Trypanothione reductase</em> high-throughput screening campaign identifies novel classes of inhibitors with anti-parasitic activity (Publications)
chemical classes of trypanothione reductase (TR) inhibitors worthy of further investigation. Hits from 5 of these chemical classes have been developed further through different combinations of preliminary
Travelers can import colistin-resistant <em>enterobacteriaceae</em> including those possessing the plasmid-mediated <em>mcr-1</em> gene (Publications)
an overnight enrichment and CHROMagar Orientation plates supplemented with colistin, four people (10.5%) were found colonized with colistin-resistant Escherichia coli One cephalosporin-susceptible ST10 strain
Expanding the rubterolone family: intrinsic reactivity and directed diversification of PKS-derived pyrans (Publications)
(tropolone alkaloids) that contain a highly reactive pyran moiety (in equilibrium with the hydrolyzed 1,5-dione form) and undergo spontaneous pyridine formation in the presence of primary amines. We exploited
Urban background particulate matter and allergic sensitization in adults of ECRHS II (Publications)
and blood tests conducted for the measurement of specific immunoglobulin E. Fine particle mass (PM(2.5),
BMI group-related differences in physical fitness and physical activity in preschool-age children: a cross-sectional analysis (Publications)
static balance (balance platform), and physical activity (PA, accelerometers) in 613 children (M age = 5.1 years, SD = 0.6). Normal weight (NW) children performed better than overweight (OW) children in aerobic
The Swiss Health Survey Project (SOMIPOPS): an example of a data collection effort from various sources (Publications)
(secondary sources) were used: income and wealth data for the whole of the original SOMIPOPS sample (N = 5,860), and health insurance records for 80% consenting members of the interviewed sample. The integration
Parallel synthesis of a series of non-functional ATP/NAD analogs with activity against trypanosomatid parasites (Publications)
substituents, 15 new ATP/NAD analogs were obtained in screening quantities. In these compounds, a 5'-desoxyadenosine moiety was conserved as key molecular recognition motif. The inhibition of P. falciparum
<em>Trypanothione reductase</em> high-throughput screening campaign identifies novel classes of inhibitors with anti-parasitic activity (Publications)
chemical classes of trypanothione reductase (TR) inhibitors worthy of further investigation. Hits from 5 of these chemical classes have been developed further through different combinations of preliminary
Klinische Bewertung von Ciclobendazol (C-C 2481) bei der Behandlung von Wurmerkrankungen des Darmes (Publications)
relatively small number of cases of ankylostomiasis, the values were, however, considerable lower (38.5 and 20.0% respectively). Since ciclobendazole is well tolerated, there is a need for studies with higher