Parallel synthesis of a series of non-functional ATP/NAD analogs with activity against trypanosomatid parasites (Publications)
substituents, 15 new ATP/NAD analogs were obtained in screening quantities. In these compounds, a 5'-desoxyadenosine moiety was conserved as key molecular recognition motif. The inhibition of P. falciparum
Bridged 1,2,4-trioxolanes: SnCl4-catalyzed synthesis and an <em>in vitro</em> study against <em>S. mansoni</em> (Publications)
A synthesis of bridged 1,2,4-trioxolanes (bridged ozonides) from 1,5-diketones and hydrogen peroxide catalyzed by SnCl(4) was developed. It was shown that the ratio of target ozonides can be affected by
Expanding the rubterolone family: intrinsic reactivity and directed diversification of PKS-derived pyrans (Publications)
(tropolone alkaloids) that contain a highly reactive pyran moiety (in equilibrium with the hydrolyzed 1,5-dione form) and undergo spontaneous pyridine formation in the presence of primary amines. We exploited
Determinants of modern paediatric healthcare seeking in rural Côte d'Ivoire (Publications)
problems. Methods: Last disease episodes of surviving children and fatal outcomes of children under 5 years of age were investigated by means of an adapted social autopsy questionnaire administered to main
Upcoming Courses | Postgraduate Programmes at Swiss TPH (Page)
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Upcoming Courses 18.03.2024 - 22.03.2024 Leadership Location: Swiss TPH, Seminar Room 5 & online Event category: Management Course Application deadline: 12.02.2024 Module of the MBA International Health [...] 04.2024 - 19.04.2024 Strategic Planning for Health Interventions Location: Swiss TPH, Seminar Room 5 & online Event category: Management Course Application deadline: 11.03.2024 Module of the MBA International [...] Event 22.04.2024 - 26.04.2024 Health Economics and Health Financing...
Clinical Statistics and Data Management | Swiss TPH (Page)
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and appendicitis inflammatory response scores. Langenbecks Arch Surg . 2022;407(5):2051-2057. DOI: 10.1007/s00423-022-02533-5 Related Topics Infectious Diseases HIV / AIDS Tuberculosis Non-Communicable Diseases [...] Based Tuberculosis Triage Testing for Hard-To-Reach Populations in Southern Africa and Lesotho The 5-year African-European TB TRIAGE+ project is a series of studies funded by the European and Developing [...] persons with HIV and Presumptive Tuberculosis ComBaCaL - Community-Based...
Safety and efficacy of oral fexinidazole in children with <em>gambiense </em>human African trypanosomiasis: a multicentre, single-arm, open-label,... (Publications)
per day for 4 days (days 1-4) followed by 600 mg (one x 600 mg tablet) once per day for 6 days (days 5-10). Children weighing 35 kg or more received oral fexinidazole of 1800 mg (three x 600 mg tablets) [...] day for 4 days (days 1-4), followed by 1200 mg (two x 600 mg tablets) once per day for 6 days (days 5-10). The primary endpoint was fexinidazole treatment success rate 12 months after end of treatment. [...] sis) completed the 10-day treatment. Treatment success rate at 12 months was 97.6%...
Evaluation of seasonal malaria chemoprevention in two areas of intense seasonal malaria transmission: secondary analysis of a household-randomised,... (Publications)
received study drugs in 2015 and 2016. These analyses focus on the approximately 10,000 children (5,000 per country) under observation each year in the SMC plus placebo group. Despite high coverage and [...] malaria and uncomplicated clinical malaria remained high in the study areas (overall incidence rates 12.5 [95% confidence interval (CI): 11.2, 14.1] and 871.1 [95% CI: 852.3, 890.6] cases per 1,000 person-years [...] children with asymptomatic malaria was 98.3% (95% CI: 88.6%, 99.8%) in...
Mining Sudanese medicinal plants for natural compounds against malaria and neglected tropical diseases (Publications)
Rutaceae. Nectandrin B exhibited the highest activity against L. donovani (IC50 4.5 µM) and the highest selectivity index (25.5). Given the urgent need for better drugs and the fact that mycetoma is the most [...] From this screening, niclosamide showed interesting activity with a minimal inhibitory concentration ˂5 µM. Furthermore, additional niclosamide analogues were tested for proof of concept. The tested compounds
Evaluation of seasonal malaria chemoprevention in two areas of intense seasonal malaria transmission: secondary analysis of a household-randomised,... (Publications)
received study drugs in 2015 and 2016. These analyses focus on the approximately 10,000 children (5,000 per country) under observation each year in the SMC plus placebo group. Despite high coverage and [...] malaria and uncomplicated clinical malaria remained high in the study areas (overall incidence rates 12.5 [95% confidence interval (CI): 11.2, 14.1] and 871.1 [95% CI: 852.3, 890.6] cases per 1,000 person-years [...] children with asymptomatic malaria was 98.3% (95% CI: 88.6%, 99.8%) in...