Seroprevalence and risk factors of <em>Leptospira </em>sp. among different groups in the Jordanian population: first study (Publications)
seropositive for Leptospira antibodies. Individuals who drink surface water (spring or rain water) had 5.69 (95% CI 2.57 to 12.60) higher odds of seropositivity compared with individuals who used municipal
Acyclic nucleoside analogues as inhibitors of Plasmodium falciparum dUTPase (Publications)
We report the discovery of novel uracil-based acyclic compounds as inhibitors of deoxyuridine 5'-triphosphate nucleotidohydrolase (dUTPase), an enzyme involved in nucleotide metabolism that has been identified
Sequence and expression of a gene from <em>Theileria annulata</em> coding for a 70-kilodalton heat-shock protein (Publications)
protein strongly homologous to hsp 70 from other organisms. Using this DNA as a probe, a homologous 2.5-kb RNA species was detected in sporozoites, piroplasms and a macroschizont-infected cell line, showing
Synthesis and antiprotozoal activity of pyridyl analogues of pentamidine (Publications)
A series of novel pyridyl analogues 1-18 of antiprotozoal drug 1,5-bis(4-amidinophenoxy)pentane (pentamidine) has been synthesized and tested for in vitro activities against Trypanosoma brucei rhodesiense
In vitro and in vivo interaction of synthetic peroxide RBx11160 (OZ277) with piperaquine in Plasmodium models (Publications)
tendency towards antagonism with mean sums of fractional inhibitory concentrations (mean Sigma FICs) of 1.5. In vivo, piperaquine and artemether were borderline antagonistic (mean Sigma FIC of 1.4). However,
Health-related quality of life measured by the SF12 in working populations: associations with psychosocial work characteristics (Publications)
to 13%, accounting for demographics, socioeconomic status, body mass index, and medical condition (5th model). Including health behavior and personality factors (full model), R2 change for work characteristics
Assessment of breast cancer opportunistic screening by clinical-pathological indicators: a population-based study (Publications)
breast cancer were identified. The proportion of DCIS with respect to invasive cases increased from 5.8% in the period 1996-2001 to 6.4% in the period 2002-2007. The median tumour size of invasive cancers
Training in flexible intensive insulin therapy improves quality of life, decreases the risk of hypoglycaemia and ameliorates poor metabolic control in... (Publications)
METHODS: We prospectively followed 45 type 1 diabetic patients of our outpatient clinic participating in 5 consecutive FIT teaching courses at the University Hospital of Basel. These courses consist of 7 weekly
Dipeptidyl enoates as potent rhodesain inhibitors that display a dual mode of action [Communication] (Publications)
B and L, and were found to be potent and selective inhibitors of rhodesain. Among them (S,E)-ethyl 5-((S)-2-{[(benzyloxy)carbonyl]amino}-3-phenylpropanamido)-7-methyl-4-oxooct-2-enoate (6) was the most
Randomized double-blind controlled Phase I/IIa trial to assess the efficacy of malaria vaccine PfCS102 to protect against challenge with <em>P.... (Publications)
720 or ISA 720 alone (control). Two weeks after 2nd immunization, volunteers were challenged using 5 infected mosquitoes. All vaccinees developed antibodies against PfCS102 versus none control. 8/8 vaccinees