A single LC-tandem mass spectrometry method for the simultaneous determination of 14 antimalarial drugs and their metabolites in human plasma (Publications)
drugs is obtained using a gradient elution of 20mM ammonium formate and acetonitrile both containing 0.5% formic acid, followed by rinsing and re-equilibration to the initial solvent composition up to 21min [...] precise (inter-day CV%: 3.1-12.6%) and sensitive (lower limits of quantification 0.15-3.0 and 0.75-5ng/ml for basic/neutral antimalarials and artemisinin derivatives, respectively). This is the first
The independent association of source-specific transportation noise exposure, noise annoyance and noise sensitivity with health-related quality of... (Publications)
difference in SF-36 scores between highest vs. lowest sensitivity tertile: Mental health -5.96 (-7.57; -4.36); general health -5.16 (-7.08; -3.24)). Within all noise parameters, we predominantly observed negative
High sensitivity detection of <em>Plasmodium</em> species reveals positive correlations between infections of different species, shifts in age... (Publications)
prevalence shifted to older age groups in LDR-FMA diagnosed infections for P. falciparum (LM: 7-9 yrs 47.5%, LDR-FMA: 10-19 yrs 74.2%) and P. vivax (LM: 4-6 yrs 24.2%, LDR-FMA: 7-9 yrs 50.9%) but not P. malariae [...] to geographical differences in Plasmodium species infection prevalence explaining between 60.6% - 74.5% of this variation for LDR-FMA and 81.8% - 90.0% for LM (except P. falciparum), respectively. CONCLUSION:
Dynamic electronic decision trees to manage childhood illness (Projects)
https://www.swisstph.ch/en/projects/project-detail/project/dynamic-electronic-decision-trees-to-manage-childhood-illness
Every year in low- and middle-income countries, more than 5 million children under the age of 5 years die from preventable illnesses due to poor clinical management at the primary health care level. In
Abundance of <em>Opisthorchis felineus </em>metacercariae in cyprinid fish in the middle Ob river basin (Tomsk region, Russia) (Publications)
ide is the main infection source in the Ob River (prevalence of infection, 100%, and intensity, 50.5 metacercariae per fish) and the common dace in the Tom River (91.1% and 12.7 metacercariae). Although [...] fish harvested in the Tomsk region. According to epidemiological survey, among 600 participants, 87.5% (n = 525) of respondents consumed river fish, with the most popular fish being cyprinids including
Swiss TPH Strategy 2025-2028 (Projects)
https://www.swisstph.ch/en/projects/project-detail/project/swiss-tph-strategy-2025-2028
for the funding period developed according to the methods of business excellence. Parallel to the 1.5-year consultation phase by the Swiss Science Council and other government agencies, the concept for [...] Business Excellence entwickelten, umsichtigen Strategie für die Förderperiode überzeugen. Parallel zur 1,5-jährigen Konsultations-Phase durch den Schweizerischen Wissenschaftsrat und andere staatliche Stellen
VIentiane mulTi gEneRational BIrth Cohort (Projects)
https://www.swisstph.ch/en/projects/project-detail/project/vientiane-multi-generational-birth-cohort
remain. Vientiane, the capital of Lao People’s Democratic Republic (Lao PDR) has approximately 1.5 of the 7.5 million Laotian population (2022) and provides a unique opportunity to examine health outcomes
The cost-effectiveness of intermittent preventive treatment for malaria in infants in Sub-Saharan Africa (Publications)
cost-effectiveness using other antimalarials. METHODS: We analysed data from 5 countries in sub-Saharan Africa using a total of 5 different IPTi drug regimens; SP, mefloquine (MQ), 3 days of chlorproguan
Impact of road traffic noise on obesity measures: observational study of three European cohorts (Publications)
from a standardised European noise assessment framework. Residential exposures to NO2 for 2007 and PM2.5 for 2010 were estimated from Europe-wide land use regression models. Obesity markers including body [...] associations were robust to most other sensitivity analyses but attenuated by further adjustment of PM2.5 or area-level socioeconomic status. Associations were more pronounced among women, those with low physical
The effect of dose on the antimalarial efficacy of artemether-lumefantrine: a systematic review and pooled analysis of individual patient data (Publications)
analyses. The PCR-adjusted therapeutic efficacy was 97.6% (95% CI 97.4-97.9) at day 28 and 96.0% (95.6-96.5) at day 42. After controlling for age and parasitaemia, patients prescribed a higher dose of artemether [...] a total lumefantrine dose less than 60 mg/kg had the lowest PCR-adjusted efficacy (91.7%, 95% CI 86.5-96.9). In Africa, the risk of treatment failure was greatest in malnourished children aged 1-3 years