Solid phase synthesis and antiprotozoal evaluation of di- and trisubstituted 5'-carboxamidoadenosine analogues (Publications)
with promising activity: N(6)-benzyl-5'-N-phenylcarboxamidoadenosine with an IC(50) value of 0.91muM against Trypanosoma brucei rhodesiense and N(6)-diphenylethyl-5'-phenylcarboxamidoadenosine with an IC(50) [...] speed up the process of lead finding and we pursued the solid-phase synthesis of di- and trisubstituted 5'-carboxamidoadenosine derivatives by using a safety-catch approach. While efforts with Kenner's sulfonamide
Few associations between high-sensitivity C-reactive protein and environmental factors in 4.5-year-old children (Publications)
C-reactive protein (hsCRP) at the age of 4.5 years. Methods: The high-sensitivity CRP values (n = 653) and serum-specific IgE concentrations were measured from 4.5-year-old children in rural areas in five [...] (aOR 2.51 95% CI 1.12-5.59). Conclusion: We found few associations between early environmental farming factors and hsCRP levels, and between hsCRP levels and atopic sensitization in 4.5-year-old children. [...] Group. Few associations between high-sensitivity C-reactive protein and...
Oxidative properties of ambient PM2.5 and elemental composition: Heterogeneous associations in 19 European cities (Publications)
extent to which constituents of PM2.5 (transition metals, sodium, chloride) contribute to the ability to generate hydroxyl radicals ((OH)-O-center dot) in vitro in PM2.5 sampled at 20 locations in 19 European [...] European centres participating in the European Community Respiratory Health Survey. PM2.5 samples (n = 716) were collected on filters over one year and the oxidative activity of particle suspensions obtained
Synthesis and antitubulin activity of N1- and N4-substituted 3,5-dinitro sulfanilamides against African trypanosomes and Leishmania (Publications)
Thirty analogues of N(1)-phenyl-3,5-dinitro-N(4),N(4)-di-n-propylsulfanilamide (GB-II-5, compound 3), a new antikinetoplastid antimitotic agent, have been synthesized and evaluated. The addition of simple [...] antimitotic potency, but placement of a dibutyl substituent at the N4 nitrogen to give N(1)-phenyl-3,5-dinitro-N(4),N(4)-di-n-butylsulfanilamide (compound 35) augments antitrypanosomal and antileishmanial [...] vivo antitrypanosomal assays, the in vitro potency and selectivity of these...
Efficacy of the novel diamidine compound 2,5-Bis(4-amidinophenyl)- furan-bis-<em>O</em>-Methlylamidoxime (Pafuramidine, DB289) against <em>Trypanosoma... (Publications)
consecutive days. The animals in groups 4 and 5 were treated with 10 mg/kg for 10 consecutive days starting on the 14th day p.i. (group 4) or on the 28th day p.i. (group 5), when these animals were in the late [...] of three (group 5) monkeys. These studies demonstrated that pafuramidine was orally active in monkeys with early-stage T. brucei rhodesiense infections at dose rates above 3 mg/kg for 5 days. It was also [...] treatment with parenterally administered medicines. The efficacy of a...
Validation of a questionnaire to assess dietary habits among 5-13-year old school children of farmers and anthroposophic families (Publications)
Objective. To evaluate dietary habits among 5-13-year old school children of farmers, anthroposophic families and controls and to evaluate the validity of a food questionnaire as part of a lifestyle q
The association of LUR modeled PM2.5 elemental composition with personal exposure (Publications)
predicting personal exposures. In this study, the association of LUR modeled concentrations of PM2.5 components with measured personal concentrations was determined. The elements of interest were copper [...] sites were selected in each city (15 participants per city). Outdoor, indoor and personal 96-hour PM2.5 samples were collected by the participants over periods of two weeks in three different seasons (winter [...] with measured personal Cu exposure. After excluding observations with an...